Along with excellent patient care, our team is also actively involved in clinical research to advance the understanding of the pathophysiology, diagnosis and treatment of aerodigestive disorders. Current research initiatives include:
Understanding the role of the microbiome (microbes that inhabit the human body) in disorders of aspiration and swallowing dysfunction.
Autism Program Research
Investigators at the Autism Program understand the importance of autism research and actively pursue a wide range of studies focused on autism spectrum disorder (ASD). There is frequent collaboration among researchers both within Texas Children's Hospital and Baylor College of Medicine and with other renowned centers across the country. This includes cooperation on several network studies aimed at understanding the causes and course of ASD.
Our program was awarded a Department of Defense Congressionally Directed Medical Research Program Exploration- Hypothesis Award in the area of bone marrow failure and received an award from the Cancer Prevention Research Institute of Texas (CPRIT). This research is part of our larger efforts to uncover new pathways and molecular mechanisms contributing to bone marrow failure in children.
As one of the top programs for cell-based therapies, our research focuses on improving transplantation outcomes by reducing or avoiding infection or relapses. Another component of our research looks at viral-specific cells to see how we can ensure patients’ cells have short and long term immunity.
RELATED RESEARCH AREACell and Gene Therapy
Texas Children’s Cancer Center has the largest and most comprehensive bone tumor research program in the United States. The program is designed to integrate the work of laboratory researchers and translational researchers with clinicians who are directly involved in the care of patients with bone tumors.
Translational research takes laboratory information and “translates” it into the clinical setting. The program’s current research focuses on identifying survivors at risk for medical problems, such as heart or hormonal disturbances. A major focus of the program is also directed at early diagnosis and intervention for survivors with psychosocial and neuropsychological concerns.
A Multidimensional Approach to Improve the Treatment of Congenital Heart Disease
The vision of the Cardiovascular Clinical Research group is to optimize the outcomes for patients with congenital heart disease, and reduce the burden of such disease on them, their parents and society.
Aortic Disease Research
The Cardiovascular Genetics Clinic team is conducting research in patients with Marfan syndrome and related disorders to help determine how best to predict adverse events in young people with these disorders, and how best to improve outcomes.
The Center for Advanced Innate Cell Therapy (AICT) is a component of the Texas Children’s Cancer and Hematology Center. The AICT was established in 2021 with the overarching goal of developing safe and effective therapies for childhood cancer using natural and engineered properties of the immune system.
The Clinical Research Center (CRC) provides a clinical research infrastructure for investigators who want to conduct patient-oriented clinical research at Texas Children's Hospital.
The facility includes:
From being the lead institution on the Berlin Heart study to bioengineering involving tissue and cells in the lab, we lead the way in cardiovascular research. The Division of Congenital Heart Surgery at Texas Children’s has a variety of research endeavors in both clinical and basic science areas. We have achieved national recognition for our studies and are continuing to break new ground in some of the most exciting research areas to date.