Research

Research at Texas Children’s Hospital, the largest children’s hospital in the United States, is conducted primarily at four facilities: Feigin Center, the Jan and Dan Duncan Neurological Research Institute (NRI), Children’s Research Center (CRC) and the Children’s Nutrition Research Center (CNRC). Texas Children’s is affiliated with Baylor College of Medicine and is its primary pediatric clinical training site. 
 
Research at Texas Children’s Hospital, spans more than 800 active clinical trials, over 800,000 square feet of laboratory space, and one of the largest and most diverse pediatric patient populations in the country.
 
With funding of more than $115 million annually, over 120 Texas Children's and Baylor College of Medicine principal investigators are conducting over 1,000 clinical, basic science, and translational research projects at any given moment.The hospital has garnered widespread recognition for its expertise and breakthrough developments in the treatment of a variety of pediatric health conditions.
 
Research at Texas Children's is conducted in four major centers -
  • The Feigin Center 
    Houses most of the research labs engaged in basic and clinical pediatrics research.
     
  • The Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) 
    A one-of-a-kind basic research institutes devoted to understanding neurological diseases.
     
  • The Children's Nutrition Research Center (CNRC) 
    A unique cooperative venture between Texas Children's Hospital, Baylor College of Medicine and the U.S. Department of Agriculture/Agricultural Research Service.
     
  • The Clinical Research Center (CRC)
    Provides a clinical research infrastructure for investigators who want to conduct patient-oriented clinical research at Texas Children’s Hospital.

Our recent discoveries

A new treatment regimen for adolescents with chronic Hepatitis C virus infection identified (Jan 30, 2019)
A study led by Dr. Daniel Leung, Associate Professor and Director of the Viral Hepatitis Programat Texas Children’s Hospital and Baylor College of Medicine reports a new treatment for adolescents affected by chronic Hepatitis C infections (HCV). This study was a part of an ongoing, three-part clinical trial called ZIRCON, a multi-center international effort to find safe and effective therapies to treat HCV in children and was published in Hepatology Communications.


New insights into Zika's microcephaly link, similarity to dengue (Dec 13, 2018)
New insights into how dengue and Zika viruses cause disease reveal shared and virus-specific mechanisms. An international, multi-institutional team led by researchers of the University of California, San Francisco and Baylor College of Medicine report in the journal Cell that these viruses counteract a human and mosquito immune defense mechanism and hijack specific host proteins for virus replication. They also discovered that Zika virus causes microcephaly in fruit flies by disrupting the function of ANKLE2, a protein involved in brain development both in flies and humans. These findings open new avenues to design therapeutic strategies to combat these widespread and severe infectious diseases.


Research reveals defective transport of lysosomal enzymes causes a type of Batten disease (Nov 7, 2018)
Neuronal Ceroid Lipofuscinoses (NCLs a.k.a. Batten disease) are a group of fatal neurodegenerative disorders that result from defective lysosomal function due to mutations in different CLN genes. A surprising discovery from the laboratory of Dr. Marco Sardiello, assistant professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital shows defective lysosomal biogenesis as the underlying cause of Neuronal Ceroid Lipofuscinoses 8 (NCL8).

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