Carlos A. Bacino, MD

Department or Service

Location

  • Texas Medical Center

Specialty

Genetics

Phone: 832-822-4292
Fax: 832-825-4294

Contact Information

6701 Fannin Street
Wallace Tower, Suite 1560
Houston, TX 77030
United States
Texas

Chief, Genetics Service

Texas Children's Hospital

Education

School Education Degree Year
Cedars-Sinai Medical Center fellowship Genetics 1994
Beth Israel Medical Center Program residency Pediatrics 1991
Beth Israel Medical Center Program internship Pediatrics 1989
Nat'l Inst of Medical Genetics-Buenos Aires residency Medical Genetics 1983
Universidad de Buenos Aires medical school Doctor of Medicine 1981

About

I am primarily dedicated to clinical activities in the Department of Molecular and Human Genetics. In the area of clinical genetics, I am involved in the diagnosis and management of patients with birth defects and a variety of genetic disorders and participate in the Skeletal Dysplasia Clinic. I am directly involved in the supervision and training of medical students, residents, and fellows. As the Medical Director of the Kleberg Cytogenetics Laboratory, I have a particular interest in structural chromosomes abnormalities and genomic disorders (contiguous gene deletion/duplication syndromes), as well as the mechanism of origin of these chromosome anomalies. In addition, I have one major area of interest:

Epigenetics and Disorders of Imprinting: In collaboration with Dr. Arthur Beaudet and Dr. Lisa Noll we are conducting a natural history study for children with Angelman syndrome supported by the Rare Disease Center Research Network (NIH). A group of Angelman syndrome patients are being brought to the Clinical Research Center at Texas Children's Hospital for developmental, clinical and EEG evaluations on a yearly basis. This is allowing us to understand progression, complications and co-morbidities. We have recently concluded two different studies using betaine, creatine and folic acid/metafolin to promote methylation and revert silencing of the paternal allele. This trial attempted to ameliorate the symptoms of Angelman syndrome by altering patterns of imprinting.

Organization

Organization Name Role
American College of Medical Genetics Member
American Society of Human Genetics Member
Society for Pediatric Research Member
Teratology Society Member

Selected Publications

Breman A, Pursley AN, Hixson P, Bi W, Ward P, Bacino CA, Shaw C, Lupski JR, Beaudet A, Patel A, Cheung SW, Van den Veyver I. Prenatal chromosomal microarray analysis in a diagnostic laboratory; experience with >1000 cases and review of the literature. Prenatal Diagnosis 2012 Apr;32(4):351-61.