Programs Publications

2021

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM.Front Cell Infect Microbiol. 2021 Aug 24;11:708325. doi: 10.3389/fcimb.2021.708325. eCollection 2021. PMID: 34504808.

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi. Versteeg L, Adhikari R, Poveda C, Villar-Mondragon MJ, Jones KM, Hotez PJ, Bottazzi ME, Tijhaar E, Pollet J.PLoS Negl Trop Dis. 2021 Sep 3;15(9):e0009689. doi: 10.1371/journal.pntd.0009689. eCollection 2021 Sep.PMID: 34478444.

Identification of vaccine targets in pathogens and design of a vaccine using computational approaches. Rawal K, Sinha R, Abbasi BA, Chaudhary A, Nath SK, Kumari P, Preeti P, Saraf D, Singh S, Mishra K, Gupta P, Mishra A, Sharma T, Gupta S, Singh P, Sood S, Subramani P, Dubey AK, Strych U, Hotez PJ, Bottazzi ME.Sci Rep. 2021 Sep 2;11(1):17626. doi: 10.1038/s41598-021-96863-x.PMID: 34475453.

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW.Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2111172118. doi: 10.1073/pnas.2111172118. PMID: 34426525.

Case Report: HTLV-1-Induced Adult T-Cell Leukemia and Tropical Spastic Paresis. Rosenthal R, Kaplan J, Ahmed M, Mims M, Weatherhead JE. Am J Trop Med Hyg. 2021 Sep 20:tpmd201656. doi: 10.4269/ajtmh.20-1656. Online ahead of print.PMID: 34544038.

Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization. Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DB.Immunity. 2021 Sep 3:S1074-7613(21)00339-3. doi: 10.1016/j.immuni.2021.08.009. Online ahead of print.PMID: 34506733.

 A systematic review of historical and current trends in Chagas disease. Álvarez-Hernández DA, García-Rodríguez-Arana R, Ortiz-Hernández A, Álvarez-Sánchez M, Wu M, Mejia R, Martínez-Juárez LA, Montoya A, Gallardo-Rincon H, Vázquez-López R, Fernández-Presas AM.Ther Adv Infect Dis. 2021 Aug 4;8:20499361211033715. doi: 10.1177/20499361211033715.

 Optimization of DNA Extraction from Field-Collected Mammalian Whole Blood on Filter Paper for Trypanosoma cruzi (Chagas Disease) Detection. Gulas-Wroblewski BE, Kairis RB, Gorchakov R, Wheless A, Murray KO.Pathogens. 2021 Aug 17;10(8):1040. doi: 10.3390/pathogens10081040. PMID: 34451504.

 Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama. Bermúdez SE, Armstrong BA, Domínguez L, Krishnavajhala A, Kneubehl AR, Gunter SM, Replogle A, Petersen JM, Lopez JE. PLoS Negl Trop Dis. 2021 Aug 16;15(8):e0009642. doi: 10.1371/journal.pntd.0009642. eCollection 2021 Aug.PMID: 34398885.

 Mounting antiscience aggression in the United States. Hotez PJ.PLoS Biol. 2021 Jul 28;19(7):e3001369. doi: 10.1371/journal.pbio.3001369. eCollection 2021 Jul.PMID: 34319972.

 Myocarditis With COVID-19 mRNA Vaccines. Bozkurt B, Kamat I, HotezPJ.Circulation. 2021 Aug 10;144(6):471-484. doi: 10.1161/CIRCULATIONAHA.121.056135. Epub 2021 Jul 20. PMID: 34281357.

Receptor-binding domain recombinant protein RBD219-N1C1 on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Bottazzi ME. bioRxiv. 2021 Jul 7:2021.07.06.451353. doi: 10.1101/2021.07.06.451353. Preprint. PMID: 34268512.

 A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, SutharMS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. Sci Immunol. 2021 Jul 15;6(61):eabh3634. doi: 10.1126/sciimmunol.abh3634.PMID: 34266981.

 The epidemiology of human ehrlichiosis in Texas, 2008-2017. Erickson TA, Mayes B, Murray KO, Gunter SM.Ticks Tick Borne Dis. 2021 Jul 12;12(6):101788. doi: 10.1016/j.ttbdis.2021.101788. Online ahead of print.PMID: 34325087

Trypanosoma cruzi in Nonischemic Cardiomyopathy Patients, Houston, Texas, USA.Nolan MS, Aguilar D, Misra A, Gunter SM, Erickson T, Gorchakov R, Rivera H, Montgomery SP, Murray KO. Emerg Infect Dis. 2021 Jul;27(7):1958-1960. doi: 10.3201/eid2707.203244.PMID: 34152952.

 Molecular Detection of Soil-Transmitted Helminths and Enteric Protozoa Infection in Children and Its Association with Household Water and Sanitation in Manhiça District, Southern Mozambique. Grau-Pujol B, Cuamba I, Jairoce C, Cossa A, Da Silva J, SacoorC, Dobaño C, Nhabomba A, Mejia R, Muñoz J.Pathogens. 2021 Jul 3;10(7):838. doi: 10.3390/pathogens10070838.PMID: 34357988.

“Die Welt darf jetzt nich nachlassen!  Hotez PJ, Miguel E, Kremer M, ZEIT ONLINE, July 13, 2021

Biden battles a triple-headed monster on vaccines.  Hotez PJ.  THE DAILY BEAST, July 19, 2021.

Challenges facing COVID-19 vaccination in India: Lessons from the initial vaccine rollout. Pandey A, Sah P, Moghadas SM, Mandal S, Banerjee S, Hotez PJ, Galvani AP.J Glob Health. 2021 Jun 26;11:03083. doi: 10.7189/jogh.11.03083.PMID: 34221355. 

 Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine. Li G, Hoeweler L, Keegan B, Peng J, Scholte L, Hotez P, Bottazzi ME, Diemert D, Bethony J.Vaccine X. 2021 Jun 6;8:100100. doi: 10.1016/j.jvacx.2021.100100. eCollection 2021 Aug.PMID: 34169270. 

 Making it personal: science communication for the masses. Sullivan WJ Jr, Strathdee SA, Hotez PJ.Trends Parasitol. 2021 Jun 16:S1471-4922(21)00133-1. doi: 10.1016/j.pt.2021.05.010. Online ahead of print.PMID: 34147337. 

Beyond the jab: A need for global coordination of pharmacovigilance for COVID-19 vaccine deployment. Naniche D, Hotez P, Bottazzi ME, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow D, Kim JH, Lall B, Larson H, Sheahan T, Shoham S, Wilder-Smith A, Sow SO, Strub-Wourgaft N, Yadav P, Batista C.EClinicalMedicine. 2021 Jun;36:100925. doi: 10.1016/j.eclinm.2021.100925. Epub 2021 Jun 3.PMID: 34099998.

Trypanosoma cruzi in Nonischemic Cardiomyopathy Patients, Houston, Texas, USA. Nolan MS, Aguilar D, Misra A, Gunter SM, Erickson T, Gorchakov R, Rivera H, Montgomery SP, Murray KO. Emerg Infect Dis. 2021 Jul;27(7):1958-1960. doi: 10.3201/eid2707.203244.PMID: 34152952 

“Counteract the anti-vaccine anti-science aggression”.  Hotez PJ. USA TODAY, June 2, 2021.

“Here’s Who’s Facing a Nightmare ‘Vaxx Summer’” Hotez PJ,  THE DAILY BEAST, June 11, 2021.

 Restoring Vaccine Diplomacy. Hotez PJ, Narayan KMV.JAMA. 2021 May 28. doi: 10.1001/jama.2021.7439. Online ahead of print.PMID: 34047758.

 Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ.bioRxiv. 2021 May 21:2021.05.20.444848. doi: 10.1101/2021.05.20.444848. Preprint. PMID: 34031655.

 Childhood immunization during the COVID-19 pandemic in Texas. Nuzhath T, Ajayi KV, Fan Q, Hotez P, Colwell B, Callaghan T, Regan AK.Vaccine. 2021 Apr 27:S0264-410X(21)00509-0. doi: 10.1016/j.vaccine.2021.04.050. Online ahead of print. PMID: 34020814.

 Preventing the next pandemic and tackling antiscience: an interview with Peter Hotez. Hotez P. Future Microbiol. 2021 May;16:539-541. doi: 10.2217/fmb-2021-0088. Epub 2021 May 17.PMID: 33998265

 Rickettsial infections: A blind spot in our view of neglected tropical diseases. Salje J, Weitzel T, Newton PN, Varghese GM, Day N.PLoS Negl Trop Dis. 2021 May 13;15(5):e0009353. doi: 10.1371/journal.pntd.0009353. eCollection 2021 May. PMID: 33983936.

Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME.Appl Microbiol Biotechnol. 2021 May;105(10):4153-4165. doi: 10.1007/s00253-021-11281-3. Epub 2021 May 7. PMID: 33959781. 

Lives and Costs Saved by Expanding and Expediting COVID-19 Vaccination. Bartsch SM, Wedlock PT, O'Shea KJ, Cox SN, Strych U, Nuzzo JB, Ferguson MC, Bottazzi ME, Siegmund SS, Hotez PJ, Lee BY.J Infect Dis. 2021 May 6:jiab233. doi: 10.1093/infdis/jiab233. Online ahead of print. PMID: 33954775.

 The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology. Jackson-Litteken CD, Ratliff CT, Kneubehl AR, Siletti C, Pack L, Lan R, Huynh TN, Lopez JE, Blevins JS.Infect Immun. 2021 May 17;89(6):e00787-20. doi: 10.1128/IAI.00787-20. Print 2021 May 17.

 A 20-year historical review of West Nile virus since its initial emergence in North America: Has West Nile virus become a neglected tropical disease? Ronca SE, Ruff JC, Murray KO. PLoS Negl Trop Dis. 2021 May 6;15(5):e0009190. doi: 10.1371/journal.pntd.0009190. eCollection 2021 May.

“Producing a vaccine requires more than a patent” Hotez PJ, Bottazzi ME, Prashant Y, FOREIGN AFFAIRS, May 10, 2021.

“We must learn from the historic decimation of Hispanic communities” Hotez PJ, Garcia S, HOUSTON CHRONICLE, May 21, 2021. 

“The only way to resolve the Wuhan ‘lab leak’ controversy” Hotez PJ, THE DAILY BEAST, May 28, 2021

Operation Warp Speed: implications for global vaccine security. Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members.Lancet Glob Health. 2021 Mar 26:S2214-109X(21)00140-6. doi: 10.1016/S2214-109X(21)00140-6. Online ahead of print.PMID: 33780663 

 Human rights and fair access to COVID-19 vaccines: the International AIDS Society-Lancet Commission on Health and Human Rights. Commissioners of and collaborators with the International AIDS Society–Lancet Commission on Health and Human Rights.Lancet. 2021 Apr 24;397(10284):1524-1527. doi: 10.1016/S0140-6736(21)00708-X. 

 COVID vaccines: time to confront anti-vax aggression. Hotez P.Nature. 2021 Apr;592(7856):661. doi: 10.1038/d41586-021-01084-x.PMID: 33907330.

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME.Hum Vaccin Immunother. 2021 Apr 13:1-11. doi: 10.1080/21645515.2021.1901545. Online ahead of print. PMID: 33847226.

Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI.ACS Infect Dis. 2021 Apr 12. doi: 10.1021/acsinfecdis.0c00816. Online ahead of print.PMID: 33843195 

The diadenylate cyclase, CdaA, is critical for Borrelia turicatae virulence and physiology. Jackson-Litteken CD, Ratliff CT, Kneubehl AR, Siletti C, Pack L, Lan R, Huynh TN, Lopez JE, Blevins JS.Infect Immun. 2021 Apr 12:IAI.00787-20. doi: 10.1128/IAI.00787-20. Online ahead of print.

“A normal summer depends on these key vaccine holdouts” Hotez PJ, THE DAILY BEAST, April 22, 2021.

Advances in vaccine development for human trichuriasis. Hayon J, Weatherhead J, Hotez PJ, Bottazzi ME, Zhan B.Parasitology. 2021 Mar 24:1-40. doi: 10.1017/S0031182021000500. Online ahead of print.PMID: 33757603

 Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi. Talavera-López C, Messenger LA, Lewis MD, Yeo M, Reis-Cunha JL, Matos GM, Bartholomeu DC, Calzada JE, Saldaña A, Ramírez JD, Guhl F, Ocaña-Mayorga S, Costales JA, Gorchakov R, Jones K, Nolan MS, Teixeira SMR, Carrasco HJ, Bottazzi ME, Hotez PJ, Murray KO, Grijalva MJ, Burleigh B, Grisard EC, Miles MA, Andersson B.Front Cell Infect Microbiol. 2021 Mar 3;11:614665. doi: 10.3389/fcimb.2021.614665. eCollection 2021.PMID: 33747978 

COVID-19 Vaccine Decisions: Considering the Choices and Opportunities. Hotez PJ, Nuzhath T, Callaghan T, Colwell B.Microbes Infect. 2021 Mar 17:104811. doi: 10.1016/j.micinf.2021.104811. Online ahead of print.PMID: 33744495 

Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME.Biochim Biophys Acta Gen Subj. 2021 Mar 14;1865(6):129893. doi: 10.1016/j.bbagen.2021.129893. Online ahead of print.PMID: 33731300 

Correcting COVID-19 vaccine misinformation: Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members. Hotez P, Batista C, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Shoham S, Wilder-Smith A, Strub-Wourgaft N, Yadav P, Bottazzi ME.EClinicalMedicine. 2021 Mar;33:100780. doi: 10.1016/j.eclinm.2021.100780. Epub 2021 Mar 6.PMID: 33718854 

Announcing the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA. Commissioners of the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA.Lancet. 2021 Mar 27;397(10280):1165-1167. doi: 10.1016/S0140-6736(21)00372-X. Epub 2021 Feb 24.PMID: 33639088 

Hotez PJ, Bottazzi ME, “Five myths about coronavirus vaccines” WASHINGTON POST, March 19, 2021.

Hotez PJ, “The antiscience movement is escalating, going global and killing thousands” SCIENTIFIC AMERICAN, March 29, 2021.

Announcing the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA. Commissioners of the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA.Lancet. 2021 Feb 24:S0140-6736(21)00372-X. doi: 10.1016/S0140-6736(21)00372-X. Online ahead of print.PMID: 33639088

The Benefits of Vaccinating With the First Available COVID-19 Coronavirus Vaccine.

Bartsch SM, O'Shea KJ, Wedlock PT, Strych U, Ferguson MC, Bottazzi ME, Randall SL, Siegmund SS, Cox SN, Hotez PJ, Lee BY.Am J Prev Med. 2021 Jan 19:S0749-3797(21)00021-0. doi: 10.1016/j.amepre.2021.01.001. Online ahead of print.PMID: 33632650

Prioritizing COVID-19 vaccinations for individuals with intellectual and developmental disabilities. Hotez E, Hotez PJ, Rosenau KA, Kuo AA.EClinicalMedicine. 2021 Feb;32:100749. doi: 10.1016/j.eclinm.2021.100749. Epub 2021 Feb 5.PMID: 33585807

America's deadly flirtation with anti-science and the medical freedom movement. Hotez PJ. J Clin Invest. 2021 Feb 25:149072. doi: 10.1172/JCI149072. Online ahead of print.PMID: 33630759

Lessons from an Ally: Learning from Israel to Vaccinate the American People. Blake A, Hotez PJ, Israeli A, Chinitz D.Microbes Infect. 2021 Feb 9:104796. doi: 10.1016/j.micinf.2021.104796. Online ahead of print.PMID: 33577990

Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection. Cruz-Chan JV, Villanueva-Lizama LE, Versteeg L, Damania A, Villar MJ, González-López C, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM.Sci Rep. 2021 Feb 5;11(1):3222. doi: 10.1038/s41598-021-82930-w.PMID: 33547365

We have to get it right: Ensuring success. Mokdad AH, Hotez PJ, Orenstein WA.EClinicalMedicine. 2021 Jan;31:100690. doi: 10.1016/j.eclinm.2020.100690.  

Urgent needs of low-income and middle-income countries for COVID-19 vaccines and therapeutics. Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members.Lancet. 2021 Jan 28:S0140-6736(21)00242-7. doi: 10.1016/S0140-6736(21)00242-7. Online ahead of print. PMID: 33516284. 

Vaccinating cassandra. Hotez PJ. EClinicalMedicine. 2021 Jan;31:100711. doi: 10.1016/j.eclinm.2020.100711. Epub 2021 Jan 5.PMID: 33426513. 

The history of the neglected tropical disease movement. Molyneux DH, Asamoa-Bah A, Fenwick A, Savioli L, Hotez P. Trans R Soc Trop Med Hyg. 2021 Jan 28;115(2):169-175. doi: 10.1093/trstmh/trab015.PMID: 33508096.

Anti-science kills: From Soviet embrace of pseudoscience to accelerated attacks on US biomedicine. Hotez PJ.PLoS Biol. 2021 Jan 28;19(1):e3001068. doi: 10.1371/journal.pbio.3001068. eCollection 2021 Jan.PMID: 33507935 

Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. Ryan NM, Hess JA, de Villena FP, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D.NPJ Vaccines. 2021 Jan 26;6(1):17. doi: 10.1038/s41541-020-00276-2.PMID: 33500417 

Hotez PJ. “Vaccine distribution is a disaster. But it’s not too late to fix it.  WASHINGTON POST, January 11, 2021.

Friedberg D, Hotez PJ.  “The vaccine rollout.” PAIRAGRAPH, January 15, 2021

Hotez PJ, “Biden’s new vaccine goal is more ambitious. It still isn’t enough” WASHINGTON POST, January 26, 2021.

2020

Preparing for SARS-CoV-2 Vaccines in US Immigrant Communities: Strategies for Allocation, Distribution, and Communication. Clark EH, Fredricks K, Woc-Colburn L, Bottazzi ME, Weatherhead J. Am J Public Health. 2020 Dec 22:e1-e5. doi: 10.2105/AJPH.2020.306047.

Urban versus Rural Prevalence of Intestinal Parasites Using Multi-Parallel qPCR in Colombia. Bryan PE, Romero M, Sánchez M, Torres G, Gómez W, Restrepo M, Restrepo A, Mejia R. Am J Trop Med Hyg. 2020 Dec 14. doi: 10.4269/ajtmh.20-1202.

Pathogenesis of Relapsing Fever. Lopez J, Hovius JW, Bergström S.Curr Issues Mol Biol. 2020 Dec 29;42:519-550. doi: 10.21775/cimb.042.519.

Hotez PJ, “COVID19 Vaccine: The 2021 Diplomatic Currency”, ISPI: ITALIAN INSTITUTE FOR INTERNATIONAL POLITICAL STUDIES, December 28, 2020.

I’ll take the first FDA-authorized vaccine offered. Hotez PJ. Houston Chronicle. Nov 29, 2020

Vaccination with chimeric protein induces protection in murine model against ascariasis. de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Zhan B, Bottazzi ME, Hotez PJ, Bueno LL, Bartholomeu DC, Fujiwara RT.Vaccine. 2020 Nov 26:S0264-410X(20)31499-7. doi: 10.1016/j.vaccine.2020.11.046

Wednesday, January 20, 2021. Hotez PJ.Microbes Infect. 2020 Nov 18:S1286-4579(20)30204-5. doi: 10.1016/j.micinf.2020.11.002. Online ahead of print.PMID: 33220444. 

NTDs in the age of urbanization, climate change, and conflict: Karachi, Pakistan as a case study. Fazal O, Hotez PJ.PLoS Negl Trop Dis. 2020 Nov 12;14(11):e0008791. doi: 10.1371/journal.pntd.0008791. eCollection 2020 Nov.PMID: 33180793 

Towards a comprehensive research and development plan to support the control, elimination and eradication of neglected tropical diseases. Mabey D, Agler E, Amuasi JH, Hernandez L, Hollingsworth TD, Hotez PJ, Lammie PJ, Malecela MN, Matendechero SH, Ottesen E, Phillips RO, Reeder JC, Szwarcwald CL, Shott JP, Solomon AW, Steer A, Swaminathan S.Trans R Soc Trop Med Hyg. 2020 Nov 11:traa114. doi: 10.1093/trstmh/traa114. Online ahead of print. 

Mining the Metabolome for New and Innovative Chagas Disease Treatments. Poveda C, Bottazzi ME, Jones KM.Trends Pharmacol Sci. 2020 Nov 25:S0165-6147(20)30262-5. doi: 10.1016/j.tips.2020.11.007. Online ahead of print.

Evidence of nickel and other trace elements and their relationship to clinical findings in acute Mesoamerican Nephropathy: A case-control analysis. Fischer RSB, Unrine JM, Vangala C, Sanderson WT, Mandayam S, Murray KO. PLoS One. 2020 Nov 10;15(11):e0240988. doi: 10.1371/journal.pone.0240988. eCollection 2020.PMID: 33170853

 Prospects for a safe COVID-19 vaccine. Haynes BF, Corey L, Fernandes P, Gilbert PB, Hotez PJ, Rao S, Santos MR, Schuitemaker H, Watson M, Arvin A.Sci Transl Med. 2020 Oct 19:eabe0948. doi: 10.1126/scitranslmed.abe0948. Online ahead of print.PMID: 33077678.  

 Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Chen WH, Tao X, Agrawal AS, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK.Vaccine. 2020 Nov 3;38(47):7533-7541. doi: 10.1016/j.vaccine.2020.09.061. Epub 2020 Sep 22. PMID: 33039209 

 The impact of in vitro cultivation on the natural life cycle of the tick-borne relapsing fever spirochete Borrelia turicatae. Krishnavajhala A, Armstrong BA, Lopez JE. PLoS One. 2020 Oct 12;15(10):e0239089. doi: 10.1371/journal.pone.0239089. eCollection 2020.PMID: 33044963 NTDs in the 2020s: An epic struggle of effective control tools versus the Anthropocene.Hotez PJ.PLoS Negl Trop Dis. 2020 Sep 24;14(9):e0007872. doi: 10.1371/journal.pntd.0007872. eCollection 2020 Sep.PMID: 32970664 Free article. No abstract available.

Anti-Science Extremism in America: Escalating and Globalizing. Hotez PJ.Microbes Infect. 2020 Sep 19:S1286-4579(20)30158-1. doi: 10.1016/j.micinf.2020.09.005. Online ahead of print.PMID: 32961275

Lancet COVID-19 Commission Statement on the occasion of the 75th session of the UN General Assembly. Lancet COVID-19 Commissioners, Task Force Chairs, and Commission Secretariat.Lancet. 2020 Sep 14:S0140-6736(20)31927-9. doi: 10.1016/S0140-6736(20)31927-9. Online ahead of print.PMID: 32941825 Free PMC article. Review. No abstract available.

Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ, Grobusch MP; HookVac Consortium.Lancet Infect Dis. 2020 Sep 11:S1473-3099(20)30288-7. doi: 10.1016/S1473-3099(20)30288-7. Online ahead of print.PMID: 32926834

A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Liu Z, Kundu R, Damena S, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME.Protein Expr Purif. 2020 Sep 10;177:105750. doi: 10.1016/j.pep.2020.105750. Online ahead of print.PMID: 32920041

A new Korean Research Investment for Global Health Technology (RIGHT) Fund to advance innovative neglected-disease technologies. Hotez PJ, Bush K, Oswald A, Rockman G, Lim IT, Jee Y, Moon CJ, Kim JH, Kim Y. PLoS Negl Trop Dis. 2020 Sep 3;14(9):e0007956. doi: 10.1371/journal.pntd.0007956. eCollection 2020 Sep.PMID: 32881862 Free PMC article.

Low Trypanosoma cruzi transmission risk to humans in the Trans-Pecos region of Texas. Dye-Braumuller KC, Lynn MK, Gorchakov R, Gunter SM, Berry RM, Murray KO, Nolan MS. Parasite Epidemiol Control. 2020 Sep 9;11:e00180. doi: 10.1016/j.parepi.2020.e00180. eCollection 2020 Nov.PMID: 33005772.

Design and Evaluation of Risk Assessment Tools to Identify Pediatric Tuberculosis Infection in Bohol, the Philippines, a Low-HIV- and High-TB-Burden Setting. Gatchalian SR, Agathis NT, Castillo-Carandang NT, Gunter SM, Murray KO, Mandalakas AM.Am J Trop Med Hyg. 2020 Sep 21. doi: 10.4269/ajtmh.20-0244.

Ness TE, Agrawal V, Bedard K, Ouellette L, Erickson TA, Hotez P, Weatherhead JE.   Maternal Hookworm Infection and Its Effects on Maternal Health: A Systematic Review and Meta-Analysis. Am J Trop Med Hyg. 2020 Aug 24. doi: 10.4269/ajtmh.20-0503. PMID: 32840198

 Hotez PJ, Bush K, Oswald A, Rockman G, Lim I-t, Jee Y, et al. (2020) A new Korean Research Investment for Global Health Technology (RIGHT) Fund to advance innovative neglected-disease technologies. PLoS Negl Trop Dis 14(9): e0007956. https://doi.org/10.1371/journal. pntd.0007956

Chadalawada S, Sillau S, Archuleta S, Mundo W, Bandali M, Parra-Henao G, Rodriguez-Morales AJ, Villamil-Gomez WE, Suárez JA, Shapiro L, Hotez PJ, Woc-Colburn L, DeSanto K, Rassi A Jr, Franco-Paredes C, Henao-Martínez AF. Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020 Aug 3;3(8):e2015072. doi: 10.1001/jamanetworkopen.2020.15072. PMID: 32865573.

 Iyer R, Damania A. Shotgun metagenomics of indigenous bacteria collected from the banks of the San Jacinto River for biodegradation of aromatic waste. FEMS Microbiol Lett. 2020 Aug 1;367(16):fnaa133. doi: 10.1093/femsle/fnaa133. PMID: 32761171

Hotez PJ, Bottazzi ME.Developing a low-cost and accessible COVID-19 vaccine for global health. PLoS Negl Trop Dis. 2020 Jul 29;14(7):e0008548. doi: 10.1371/journal.pntd.0008548. eCollection 2020 Jul.PMID: 32726304.

Weatherhead JE. Pediatric Pharmacotherapy: Anthelminthic Treatment. Handb Exp Pharmacol. 2020;261:339-362. doi: 10.1007/164_2019_254.PMID: 31555913.

COVID-19 vaccine design: the Janus face of immune enhancement. Hotez PJ, Corry DB, Bottazzi ME. Nature Reviews Immunology. 2020 Apr 28. doi: 10.1038/s41577-020-0323-4. https://www.nature.com/articles/s41577-020-0323-4

The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement. Hotez PJ, Bottazzi ME, Corry DB. Microbes Infect. 2020 Apr 17. pii: S1286-4579(20)30072-1. doi: 10.1016/j.micinf.2020.04.005. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162764/

Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19. Chen WH, Hotez PJ, Bottazzi ME. Human Vaccines and Immunotherapies 2020 Apr 16:1-4. doi: 10.1080/21645515.2020.1740560 https://www.tandfonline.com/doi/full/10.1080/21645515.2020.1740560

Strongyloides stercoralis Infection in Solid Organ Transplant Patients is Associated with Eosinophil Activation and Intestinal Inflammation: A Cross-sectional Study. Clark E, Pritchard H, Hemmige V, Restrepo A, Bautista K, Damania A, Ricciardi A, Nutman TB, Mejia R.Clin Infect Dis. 2020 Mar 10. pii: ciaa233. doi: 10.1093/cid/ciaa233. PMID: 32155244 https://pubmed.ncbi.nlm.nih.gov/32155244/

Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study. Mejia R,Damania A, Jeun R, Bryan PE, Vargas P, Juarez M, Cajal PS, Nasser J, Krolewiecki A, Lefoulon E, Long C, Drake E, Cimino RO, Slatko B.Parasit Vectors. 2020 Apr 19;13(1):200. doi: 10.1186/s13071-020-04073-7.PMID: 32306993 https://pubmed.ncbi.nlm.nih.gov/32306993/

We need a federal task force to protect health care workers. THE HILL, April 2, 2020 Goel A, Hotez P. https://thehill.com/opinion/white-house/490765-we-need-a-federal-task-force-to-protect-health-care-workers

2017

Global urbanization and the neglected tropical diseases. Hotez PJ. PLoS Neglected Tropical Diseases. 2017 Feb 23;11(2):e0005308.

Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine. Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM. PLoS Neglected Tropical Diseases. 2017 Feb 13;11(2):e0005385. doi: 10.1371/journal.pntd.0005385.

Can the SDGs and GHSA achieve synergy? Hotez PJ. Journal of Public Health Policy. 2017 Feb 7. doi: 10.1057/s41271-016-0059-3. Review. 

The natural killer cell response to West Nile virus in young and old individuals with or without a prior history of infection.Yao Y, Strauss-Albee DM, Zhou JQ, Malawista A, Garcia MN, Murray KO, Blish CA, Montgomery RR. PLoS One. 2017 Feb 24;12(2):e0172625.

New records of Ornithodoros puertoricensis Fox 1947 (Ixodida: Argasidae) parasitizing humans in rural and urban dwellings, Panama. Bermúdez SE, Castillo E, Pohlenz TD, Kneubehl A, Krishnavajhala A, Domínguez L, Suárez A, López JE. Ticks and Tick Borne Diseases. 2017 Feb 5. pii: S1877-959X(17)30051-1.

Autism spectrum disorder: if not vaccines, then what? Hotez PJ. BCM From the Labs Blog.

Yellow Fever Global Whack-a-Mole. Hotez PJ, Aksoy S. PLOS Speaking of Medicine.

How the Anti-Vaxxers Are Winning. Hotez PJ. New York Times.

Russian-United States vaccine science diplomacy: Preserving the legacy. Hotez PJ. PLoS Negl Trop Dis. 2017 May 25;11(5):e0005320. doi: 10.1371/journal.pntd.0005320. eCollection 2017 May.

Can the SDGs and GHSA achieve synergy? Hotez PJ. J Public Health Policy. 2017 May;38(2):269-270.

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, Ahmed M, Aksut B, Alam T, Alam K, Alla F, Alvis-Guzman N, Amrock S, Ansari H, Ärnlöv J, Asayesh H, Atey TM, Avila-Burgos L, Awasthi A, Banerjee A, Barac A, Bärnighausen T, Barregard L, Bedi N, Belay Ketema E, Bennett D, Berhe G, Bhutta Z, Bitew S, Carapetis J, Carrero JJ, Malta DC, Castañeda-Orjuela CA, Castillo-Rivas J, Catalá-López F, Choi JY, Christensen H, Cirillo M, Cooper L Jr, Criqui M, Cundiff D, Damasceno A, Dandona L, Dandona R, Davletov K, Dharmaratne S, Dorairaj P, Dubey M, Ehrenkranz R, El Sayed Zaki M, Faraon EJA, Esteghamati A, Farid T, Farvid M, Feigin V, Ding EL, Fowkes G, Gebrehiwot T, Gillum R, Gold A, Gona P, Gupta R, Habtewold TD, Hafezi-Nejad N, Hailu T, Hailu GB, Hankey G, Hassen HY, Abate KH, Havmoeller R, Hay SI, Horino M, Hotez PJ, et al. J Am Coll Cardiol. 2017 May 15. pii: S0735-1097(17)37244-3. 

Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. Diemert DJ, Freire J, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J. PLoS Negl Trop Dis. 2017 May 2;11(5):e0005574.

Vector-borne diseases of public health importance for personnel on military installations in the United States. Garcia MN, Cropper TL, Gunter SM, Kramm MM, Pawlak MT, Roachell W, Ronca SE, Stidham RA, Webber BJ, Yun HC. US Army Med Dep J. 2017 Jan-Jun;(1-17):90-101.

Hookworm infection is associated with decreased CD4+ T cell counts in HIV-infected adult Ugandans. Morawski BM, Yunus M, Kerukadho E, Turyasingura G, Barbra L, Ojok AM, DiNardo A, Sowinski S, Boulware DR, Mejia R. PLoS Negl Trop Dis. 2017 May 25;11(5):e0005634

Diagnosis and Management of Borrelia turicatae Infection in Febrile Soldier, Texas, USA. Christensen AM, Pietralczyk E, Lopez JE, Brooks C, Schriefer ME, Wozniak E, Stermole B. Emerg Infect Dis. 2017 May;23(5):883-884.

Saving lives efficiently across sectors: The need for a Congressional cost-effectiveness committee. Fitzpatrick MC, Singer BH, Hotez PJ, Galvani AP. Lancet. 2017 Jun 29. pii: S0140-6736(17)31440-X. doi: 10.1016/S0140-6736(17)31440-X. 

Venezuela and its rising vector-borne neglected diseases. Hotez PJ, Basáñez MG, Acosta-Serrano A, Grillet ME. PLOS Neglected Tropical Diseases. 2017 Jun 29;11(6):e0005423. doi: 10.1371/journal.pntd.0005423. eCollection 2017 Jun. 

Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. Gunter S, Jones KM, Seid C, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Journal of Parasitology. 2017 Jun 5. doi: 10.1645/17-7. 

Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015.

A Chronological Survey of Leptospirosis in Honduras. Galo CM,  Fagerstrom KA. Current Tropical Medicine Reports (2017) 4: 47. doi:10.1007/s40475-017-0103-9

Epidemiology of Leptospirosis in Costa Rica. Carvajal MP, Fagerstrom KA. 2011–2015 Current Tropical Medicine Reports (2017) 4: 41. doi:10.1007/s40475-017-0102-x

Epidemiology of Leptospirosis in Mesoamerica: Historical Perspectives on One Health Transmission. Erickson T. Current Tropical Medicine Reports (2017) 4: 62. doi:10.1007/s40475-017-0109-3

2016

Impact of vectorborne parasitic neglected tropical diseases on child health. Barry MA, Murray KO, Hotez PJ, Jones KM. Archives of Disease in Childhood. 2016 Feb 26.

The BENEFIT Trial: Where Do We Go from Here? Pecoul B, Batista C, Stobbaerts E, Ribeiro I, Vilasanjuan R, Gascon J, Pinazo MJ, Moriana S, Gold S, Pereiro A, Navarro M, Torrico F, Bottazzi ME, Hotez PJ. PLOS Neglected Tropical Diseases. 2016 Feb 25.

A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. Human Vaccines and Immunotherapeutics. 2016 Feb 18.

Expression and Purification of an Engineered, Yeast-expressed Leishmania donovani Nucleoside Hydrolase with Immunogenic Properties. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. Human Vaccines and Immunotherapeutics. 2016 Feb 2.

Multiplexed Recombinase Polymerase Amplification Assay To Detect Intestinal Protozoa. Crannell Z, Castellanos-Gonzalez A, Nair G, Mejia R, White AC, Richards-Kortum R. Analytical Chemistry. 2016 Feb 2.

Assessment of the Geographic Distribution of Ornithodoros turicata (Argasidae): Climate Variation and Host Diversity. Donaldson TG, Pèrez de León AA, Li AI, Castro-Arellano I, Wozniak E, Boyle WK, Hargrove R, Wilder HK, Kim HJ, Teel PD, Lopez JE. PLOS Neglected Trop Diseases. 2016 Feb 1.

Transcriptional Profiling the 150 kb Linear Megaplasmid of Borrelia turicatae Suggests a Role in Vector Colonization and Initiating Mammalian Infection. Wilder HK, Raffel SJ, Barbour AG, Porcella SF, Sturdevant DE, Vaisvil B, Kapatral V, Schmitt DP, Schwan TG, Lopez JE. PLOS One. 2016 Feb 4.

The South China Sea and Its Neglected Tropical Diseases. Hotez PJ. PLOS Neglected Tropical Diseases. 2016 Mar 31;10(3):e0004395. doi: 10.1371/journal.pntd.0004395. eCollection 2016 Mar.

Status of vaccine research and development of vaccines for Chagas disease. Beaumier CM, Gillespie PM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Vaccine. 2016 Mar 26. pii: S0264-410X(16)30071-8. doi: 10.1016/j.vaccine.2016.03.074.

Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting. Bartsch SM, Hotez PJ, Hertenstein DL, Diemert DJ, Zapf KM, Bottazzi ME, Bethony JM, Brown ST, Lee BY. Vaccine. 2016 Mar 18. pii: S0264-410X(16)00329-7. doi: 10.1016/j.vaccine.2016.03.018.

Status of vaccine research and development of vaccines for leishmaniasis. Gillespie PM, Beaumier CM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Vaccine. 2016 Mar 11. pii: S0264-410X(16)00289-9. doi: 10.1016/j.vaccine.2015.12.071.

Eliminating the Neglected Tropical Diseases: Translational Science and New Technologies. Hotez PJ, Pecoul B, Rijal S, Boehme C, Aksoy S, Malecela M, Tapia-Conyer R, Reeder JC. PLOS Neglected Tropical Diseases. 2016 Mar 2;10(3):e0003895. doi: 10.1371/journal.pntd.0003895. eCollection 2016 Mar.

West Nile Virus Retinopathy and Associations with Long Term Neurological and Neurocognitive Sequelae. Hasbun R, Garcia MN, Kellaway J, Baker L, Salazar L, Woods SP, Murray KO. PLOS One. 2016 Mar 7;11(3):e0148898. doi: 10.1371/journal.pone.0148898.

Zika Virus, 'Ghostbusters,' and the Strange New Normal of Tropical Disease Pandemics. Hotez, PJ. Vice News, March 8, 2016.

Will Zika return to the 'Old World'? Hotez PJ. Microbes & Infection. 2016 May 27. pii: S1286-4579(16)30064-8. doi: 10.1016/j.micinf.2016.05.003. PMID: 27242327

Old World Cutaneous Leishmaniasis and Refugee Crises in the Middle East and North Africa. Du R, Hotez PJ, Al-Salem WS, Acosta-Serrano A. PLOS Neglected Tropical Diseases. 2016 May 26;10(5):e0004545. doi: 10.1371/journal.pntd.0004545. eCollection 2016 May. PMID: 27227772

Human anthelminthic vaccines: Rationale and challenges. Hotez PJ, Strych U, Lustigman S, Bottazzi ME. Vaccine. 2016 May 9. pii: S0264-410X(16)30259-6. doi: 10.1016/j.vaccine.2016.03.112.

Multi-stakeholder partnerships with the Democratic Peoples' Republic of Korea to improve childhood immunization. Kim H, Marks F, Novakovic U, Hotez PJ, Black RE. Tropical Medicine & International Health. 2016 May 9. doi: 10.1111/tmi.12721. PMID: 27159122

Southern Europe's Coming Plagues: Vector-Borne Neglected Tropical Diseases. Hotez PJ. PLOS Neglected Tropical Diseases. 2016 Jun 30;10(6):e0004243. doi: 10.1371/journal.pntd.0004243. eCollection 2016 Jun. 

What Does Zika Virus Mean for the Children of the Americas? Hotez PJ. JAMA Pediatrics. 2016 Jun 20. doi: 10.1001/jamapediatrics.2016.1465.  

Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein. Darwiche R, Kelleher A, Hudspeth EM, Schneiter R, Asojo OA. Scientific Reports. 2016 Jun 27;6:28838. doi: 10.1038/srep28838. PubMed PMID: 27344972; PubMed Central PMCID: PMC4921858.

Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Asojo Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, et al. Hum Vaccin Immunother. 2016 Jul 2;12(7):1707-20. doi: 10.1080/21645515.2016.1139254. Epub 2016 Feb 2. PubMed PMID: 26839079.

The World's Great Religions and Their Neglected Tropical Diseases. Hotez PJ. PLoS Negl Trop Dis. 2016 Jul 28;10(7):e0004544. doi: 10.1371/journal.pntd.0004544. eCollection 2016 Jul.

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. PLoS Negl Trop Dis. 2016 Jul 7;10(7):e0004797.

Emerging infectious diseases with cutaneous manifestations: Fungal, helminthic, protozoan and ectoparasitic infections. Kollipara R, Peranteau AJ, Nawas ZY, Tong Y, Woc-Colburn L, Yan AC, Lupi O, Tyring SK. J Am Acad Dermatol. 2016 Jul;75(1):19-30. doi: 10.1016/j.jaad.2016.04.032.

Emerging infectious diseases with cutaneous manifestations: Viral and bacterial infections. Nawas ZY, Tong Y, Kollipara R, Peranteau AJ, Woc-Colburn L, Yan AC, Lupi O, Tyring SK. J Am Acad Dermatol. 2016 Jul;75(1):1-16. doi: 10.1016/j.jaad.2016.04.033. 

NTD and NCD Co-morbidities: The Example of Dengue Fever. Mehta P, Hotez PJ. PLoS Negl Trop Dis. 2016 Aug 25;10(8):e0004619. doi: 10.1371/journal.pntd.0004619. eCollection 2016 Aug. 

A review of visceral leishmaniasis during the conflict in South Sudan and the consequences for East African countries.Al-Salem W, Herricks JR, Hotez PJ. , Parasit Vectors. 2016 Aug 22;9:460. doi: 10.1186/s13071-016-1743-7. Review.

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses.Pulko V, Davies JS, Martinez C, Lanteri MC, Busch MP, Diamond MS, Knox K, Bush EC, Sims PA, Sinari S, Billheimer D, Haddad EK, Murray KO, Wertheimer AM, Nikolich-Žugich J.  Nat Immunol. 2016 Aug;17(8):966-75.

Somalia: A Nation at the Crossroads of Extreme Poverty, Conflict, and Neglected Tropical Diseases. Jaffer A, Hotez PJ. PLoS Negl Trop Dis. 2016 Sep 29;10(9):e0004670. doi: 10.1371/journal.pntd.0004670. eCollection 2016 Sep.

The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. Parasit Vectors. 2016 Sep 27;9(1):518.

The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections. Briggs N, Weatherhead J, Sastry KJ, Hotez PJ. PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004944. doi: 10.1371/journal.pntd.0004944. eCollection 2016 Sep.

Zika Virus Is More Like Rubella Than Human Immunodeficiency Virus-Reply. Hotez PJ. JAMA Pediatr. 2016 Sep 12.

The Global Economic and Health Burden of Human Hookworm Infection.  Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, Lee BY. PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004922. doi: 10.1371/journal.pntd.0004922. eCollection 2016 Sep.

Use of Testing for West Nile Virus and Other Arboviruses. Vanichanan J, Salazar L, Wootton SH, Aguilera E, Garcia MN, Murray KO, Hasbun R. Emerg Infect Dis. 2016 Sep;22(9). doi: 10.3201/eid2209.152050.

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A. Sci Transl Med. 2016 Oct 26;8(362):362ra143.

Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME.Protein Expr Purif. 2016 Oct 20;130:129-136. doi: 10.1016/j.pep.2016.10.008. 

Blue Marble Health and the Global Burden of Disease Study 2013. Hotez PJ, Damania A, Naghavi M. PLoS Negl Trop Dis. 2016 Oct 27;10(10):e0004744. doi: 10.1371/journal.pntd.0004744.

Texas and Its Measles Epidemics. Hotez PJ. PLoS Med. 2016 Oct 25;13(10):e1002153.

Cysteine Mutagenesis Improves the Production without Abrogating Antigenicity of a Recombinant Protein Vaccine Candidate for Human Chagas Disease. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Hum Vaccin Immunother. 2016 Oct 13:0.

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. GBD 2015 Child Mortality Collaborators (Hotez PJ). Lancet. 2016 Oct 8;388(10053):1725-1774. doi: 10.1016/S0140-6736(16)31575-6.

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.  GBD 2015 Mortality and Causes of Death Collaborators (Hotez PJ). Lancet. 2016 Oct 8;388(10053):1459-1544.

Fleas and trypanosomes of peridomestic small mammals in sub-Saharan Mali. Schwan TG, Lopez JE, Safronetz D, Anderson JM, Fischer RJ, Maïga O, Sogoba N. Parasit Vectors. 2016 Oct 11;9(1):541. 

One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border. Garcia MN, O'Day S, Fisher-Hoch S, Gorchakov R, Patino R, Feria Arroyo TP, Laing ST, Lopez JE, Ingber A, Jones KM, Murray KO. PLoS Negl Trop Dis. 2016 Nov 10;10(11):e0005074. doi: 10.1371/journal.pntd.0005074.

Prolonged Detection of Zika Virus in Vaginal Secretions and Whole Blood. Murray KO, Gorchakov R, Carlson AR, Berry R, Lai L, Natrajan M, Garcia MN, Correa A, Patel SM, Aagaard K, Mulligan MJ.Emerg Infect Dis. 2017 Jan 15;23(1). doi: 10.3201/eid2301.161394. 

UN World Toilet Day. Hotez PJ, Aksoy S, McBride T, Peiperl L. PLOS Speaking of Medicine Blog. November 18, 2016.

Paying for Worms. Hotez PJ, Damania A, Naghavi M.  PLoS Negl Trop Dis. 2016 Dec 29;10(12):e0005092. doi: 10.1371/journal.pntd.0005092.

Hookworm infection. Loukas A, Hotez PJ, Diemert D, Yazdanbakhsh M, McCarthy JS, Correa-Oliveira R, Croese J, Bethony JM. Nat Rev Dis Primers. 2016 Dec 8;2:16088. doi: 10.1038/nrdp.2016.88.

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases. Hotez PJ, Kassem M. PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005072.

Imaging Borrelia turicatae producing green fluorescent protein reveals persistent colonization of Ornithodoros turicata midgut and salivary glands from nymphal acquisition through transmission. Krishnavajhala A, Wilder HK, Boyle WK, Damania A, Thornton JA, Pérez de León AA, Teel PD, Lopez JE. Appl Environ Microbiol. 2016 Dec 16. pii: AEM.02503-16. 

Sylvatic Transmission of Trypanosoma cruzi Among Domestic and Wildlife Reservoirs in Texas, USA: A Review of the Historical Literature. Gunter SM, Brown EL, Gorchakov R, Murray KO, Garcia MN. Zoonoses Public Health. 2016 Dec 2. doi: 10.1111/zph.12330. Review.

“2017 Global Infectious Diseases Threats to the United States.” Hotez PJ. PLOS Speaking of Medicine.

2015

Identification of human intestinal parasites affecting an asymptomatic peri-urban Argentinian population using multi-parallel quantitative real-time polymerase chain reaction. Cimino RO, Jeun R, Juarez M, Cajal PS, Vargas P, Echazú A, Bryan PE, Nasser J, Krolewiecki A, Mejia R. Parasites and Vectors. 2015 Jul 17;8:380.

Blue Marble Health Redux: Neglected Tropical Diseases and Human Development in the Group of 20 (G20) Nations and Nigeria. Hotez PJ. PLOS Neglected Tropical Diseases. 2015 Jul 28;9(7):e0003672. doi: 10.1371/journal.pntd.0003672. eCollection 2015 Jul.

Noncommunicable Diseases: A Globalization of Disparity? Hotez PJ, Peiperl L. PLOS Medicine. 2015 Jul 28;12(7):e1001859. doi: 10.1371/journal.pmed.1001859. eCollection 2015 Jul.

Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143. Kelleher A, Liu Z, Seid CA, Zhan B, Asojo OA. Acta Crystallographica F Structural Biology Communications. 2015 Jul;71(Pt 7):925-8. doi: 10.1107/S2053230X15009486. Epub 2015 Jun 27.

Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Martinez-Campos V, Martinez-Vega P, Ramirez-Sierra MJ, Rosado-Vallado M, Seid CA, Hudspeth EM, Wei J, Liu Z, Kwityn C, Hammond M, Ortega-López J, Zhan B, Hotez PJ, Bottazzi ME, Dumonteil E..Vaccine. 2015 Jul 17.

The Biology of the Triatomine Bugs Native to South Central Texas and Assessment of the Risk They Pose for Autochhonous Chagas Disease Exposure. Wozniak EJ, Lawrence G, Gorchakov R, Alamgir H, Dotson E, Sissel B, Sarkar S, Murray KO. Journal of Parasitology. 2015 Jul 13.

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. GBD 2013 DALYs and HALE Collaborators (includes Hotez PJ). Lancet. 2015 Aug 27. pii: S0140-6736(15)61340-X.

Mesoamerican nephropathy: A neglected tropical disease with an infectious etiology? Murray KO, Fischer RS, Chavarria D, Duttmann C, Garcia MN, Gorchakov R, Hotez PJ, Jiron W, Leibler JH, Lopez JE, Mandayam S, Marin A, Sheleby J. Microbes and Infection. 2015 Aug 28.

Worm Infections in Children. Weatherhead JE, Hotez PJ. Pediatric Rev. 2015 Aug;36(8):341-54.

Vaccine Science Diplomacy: Expanding Capacity to Prevent Emerging and Neglected Tropical Diseases Arising from Islamic State (IS)-Held Territories. Hotez PJ. PLOS Neglected Tropical Diseases. 2015 Sep 24;9(9):e0003852.

New Vaccines for the World's Poorest People. Hotez PJ, Bottazzi ME, Strych U. Annual Review of Medicine. 2015 Sep 3. PMID: 26356803.

In Response. Mejia R. American Journal of Tropical Medicine and Hygiene. 2015 Sep 2;93(3):673. doi: 10.4269/ajtmh.15-0374b. PMID: 26333730.

Impact of the Neglected Tropical Diseases on Human Development in the Organisation of Islamic Cooperation Nations. Hotez PJ, Herricks JR. PLOS Neglected Tropical Diseases. 2015 Nov 25;9(11):e0003782.

Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Gunter SM, Jones KM, Zhan B, Essigmann HT, Murray KO, Garcia MN, Gorchakov R, Bottazzi ME, Hotez PJ, Brown EL. American Journal of Tropical Medicine and Hygiene. 2015 Nov 23. pii: 15-0438.

Historical Perspectives on the Epidemiology of Human Chagas Disease in Texas and Recommendations for Enhanced Understanding of Clinical Chagas Disease in the Southern United States. Garcia MN, Woc-Colburn L, Aguilar D, Hotez PJ, Murray KO. PLOS Neglected Tropical Diseases. 2015 Nov 5;9(11):e0003981.

The emergence of zoonotic Onchocerca lupi infection in the United States - A case-series. Cantey PT, Weeks J, Edwards M, Rao S, Ostovar GA, Dehority W, Alzona M, Swoboda S, Christiaens B, Ballan W, Hartley J, Terranella A, Weatherhead J, Dunn JJ, Marx DP, Hicks MJ, Rauch RA, Smith C, Dishop MK, Handler MH, Dudley RW, Chundu K, Hobohm D, Feiz-Erfan I, Hakes J, Berry RS, Stepensaski S, Greenfield B, Shroeder L, Bishop H, de Aleida M, Mathison B, Eberhard M. Clinical Infectious Diseases. 2015 Nov 26. pii: civ983.

The 1899 United States Kissing Bug Epidemic. Garcia MN, Hernandez D, Gorchakov R, Murray KO, Hotez PJ. PLOS Neglected Tropical Diseases 2015 Dec 1;9(12):e0004117. doi: 10.1371/journal.pntd.0004117.

Mucocutaneous manifestations of helminth infections: Trematodes and cestodes. Lupi O, Downing C, Lee M, Bravo F, Giglio P, Woc-Colburn L, Tyring SK. Journal of the American Academy of Dermatology. 2015 Dec;73(6):947-57.

Mucocutaneous manifestations of helminth infections: Nematodes. Lupi O, Downing C, Lee M, Pino L, Bravo F, Giglio P, Sethi A, Klaus S, Sangueza OP, Fuller C, Mendoza N, Ladizinski B, Woc-Colburn L, Tyring SK. Journal of the American Academy of Dermatology. 2015 Dec;73(6):929-44.