Texas Children's Global Health Childhood Tuberculosis (TB) Program

<p>Childhood Tuberculosis (TB) Program</p>

Texas Children’s Hospital Global Childhood Tuberculosis (TB) Program is committed to the prevention, diagnosis, and treatment of tuberculosis.

Launched in 2011, Texas Children's Hospital and Baylor College of Medicine initiated the Global TB Program led by TB expert Dr. Anna Maria Mandalakas. The Program aims to address gaps associated with pediatric TB care and treatment in the most vulnerable populations throughout the world. Working in alignment with the World Health Organization, the program uses research, education, program implementation, and advocacy to prevent, diagnose, and treat TB in children and adolescents.

What if we could provide every child living with HIV and their family an opportunity to lead a healthy and fulfilled life?


Give to Global TB

Thank you for supporting the Global Childhood Tuberculosis program at Texas Children's Hospital. Your gift helps us develop and provide life-saving diagnostics and treatment to improve the lives of individuals suffering from TB.

Our Mission

The Texas Children’s Global Childhood TB program mission is to advance evidence based programming that effectively prevents, finds, cures, and ultimately eliminates tuberculosis.

To advance our mission, our team works in four inter-related areas including disease prevention, diagnostics, treatment, and immunology. These program domains are built upon a data collection core and complemented by rigorous epidemiological and operational research.

A critical step towards achieving our goals is the establishment of a network of Tuberculosis Centers of Excellence built upon Texas Children’s Global Health existing clinical infrastructure.

 The fulcrum of the Global TB Program is based in Mbabane, Eswatini. In 2015, the Texas Children’s Hospital Global TB Centre of Excellence opened as a clinical and laboratory facility to serve as a national referral center for pediatric TB and host a broad range of translational research projects at the Baylor Foundation-Eswatini Clinical Centre of Excellence. The facility has been specifically designed to support cutting edge research that will elucidate the pathophysiology of HIV-TB co-infection and inform the development of future preventive and treatment interventions.

The Challenge


TB is the leading infectious disease killer in the world. Every year, TB causes disease and suffering in 10 million people and claims the lives of 1.5 million. Despite the discovery of effective treatment, TB remains one of the most dangerous infectious diseases in our world and relentlessly targets our most vulnerable populations .


Children and adolescents in all communities, and people combatting HIV, malnutrition, and poverty are disproportionately affected by TB due to inadequate preventive services, poor diagnostic tests, large case detection gaps, limited access to TB care, treatment adherence challenges, and the existence of suffocating stigma.

Our Approach

The Global TB Program embraces a collaborative approach to achieve sustainable impact.

We leverage partnerships with Texas Children’s Hospital, Baylor College of Medicine and experts at leading institutions around the globe to generate evidence to advance the care and treatment of children and families combatting TB. 

We collectively develop effective, sustainable, standardized methods of diagnosing tuberculosis in children and adolescents while identifying biomarkers correlating with progression from tuberculosis infection to disease, as well as standardizing screening processes to better characterize epidemiological risk factors for tuberculosis.

The Global TB Program partners with the World Health Organization to perform expert reviews of child TB screening and diagnostic tools and regularly serves as experts on guideline development groups to inform policy regarding the care and treatment of children and adolescents combatting tuberculosis in all countries.

Case Detection

We work on novel programmatic strategies to increase TB case finding through community outreach.


We are addressing challenges with obtaining child TB diagnostic specimens by improving diagnostics in easily obtained specimen types such as stool as well as evaluating existing approaches to diagnosing TB disease and infection in children.


We are frequently called on to report on best practices for TB treatment in children and children living with HIV.

Translational Immunology

Tuberculosis is the archetypical chronic infection that inhibits host immunity. Epigenetic mediated immune exhaustion is one means of TB induced long-lasting immune inhibition.

World Health Organization Reviews

We have partnered with colleagues on reviews that inform World Health Organization child TB diagnostic and screening guidelines in children.

Where We Work

With support from the U.S. Centers for Disease Control & Prevention, U.S. Department of Defense, European & Developing Countries Clinical Trials Partnership, U.S. National Institutes of Health, StopTB, TB Reach, and Thrasher Research Fund, we have an extensive funding portfolio that covers both research and programmatic activities in nine countries around the world.


Regional headquarters; Delivering TB clinical care, training and education, and robust research leader – providing regional TB expertise across the TCH Global Health Network


Partner sites conducting diagnostic research studies for pediatric and young adult clinical care advancement


Serving as technical support for TB and coinfections (e.g., malnutrition) 


Clinical care providers and national TB training leaders


Community-based initiative to improve child TB case finding and narrow the case detection gap

View our Recent Scholarly Activity

Leadership & Partnerships


Anna Maria Mandalakas, MD, MSEpi, PhD 
Director, Texas Children’s Global TB Program 
Professor, Pediatrics, Baylor College of Medicine

Alexander Kay, MD 
Associate Director, Texas Children’s Global TB Program 
Assistant Professor, Pediatrics, Baylor College of Medicine

Andrew DiNardo, MD 
Director of Translational Research, Texas Children’s Global TB Program 
Assistant Professor, Pediatrics, Baylor College of Medicine

Tara Devezin, MID 
Program Manager, Texas Children’s Global TB Program

Patricia Dorman 
Senior Administrative Coordinator, Texas Children’s Global TB Program

Beto Mendez-Reyes, MD, MA 
Biostatistician, Texas Children’s Global TB Program


  • Amsterdam Institute for Global Health and Development
  • U.S. Centers for Disease Control & Prevention
  • U.S. Department of Defense
  • U.S. Department of Foreign Affairs & Trade
  • ExxonMobil Papua New Guinea
  • Eswatini National TB Control Programme
  • Barcelona Institute for Global Health (ISGlobal)
  • London School of Hygiene & Tropical Medicine
  • Manhiça Health Research Centre, Radboud University
  • U.S. National Institutes of Health – National Institute of Allergy & Infectious Disease
  • Tanzania National Institute for Medical Research – Mbeya Medical Research Centre
  • Research Centre Borstel
  • Tulane University
  • University of Ottowa

Featured Stories

Fighting to close the GAP on global pediatric TB care

Building upon the energy of Global TB Program staff members and with nearly a decade of robust TB experience and innovation, the Global TB Program was most recently awarded a five-year, $5 million Centers for Disease Control and Prevention (CDC) grant that will operate from September 2020 through September 2025. This five year project, “Closing – TB GAPS – for people living with HIV: TB Guidance for Adaptable Patient-centered Services” (TB GAPS), will focus on finding and preventing TB in children and youth, while simultaneously determining the most cost-effective prevention strategy and promoting best practices to sustain the impact of our work.

Texas Children’s Global Health Network leads efforts that advance healthcare equity through innovative collaboration in care, education and research globally.

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