Resources Tuberculosis Publications

2021

Ronge L, Sloot R, Du Preez K, Kay AW, Kirchner HL, Grewal HMS, Mandalakas AM, Hesseling AC. The Magnitude of Interferon Gamma Release Assay Responses in Children With Household Tuberculosis Contact Is Associated With Tuberculosis Exposure and Disease Status. Pediatr Infect Dis J. 2021 Aug 1;40(8):763-770. doi: 10.1097/INF.0000000000003196. PMID: 34050092; PMCID: PMC8277676.

Heyckendorf J, Reimann M, Marwitz S, Lange C; DZIF-TB cohort study group. Pathogen-free diagnosis of tuberculosis. Lancet Infect Dis. 2021 Aug;21(8):1066. doi: 10.1016/S1473-3099(21)00337-6. PMID: 34331877.

Heyckendorf J, Marwitz S, Reimann M, Avsar K, DiNardo AR, Günther G, Hoelscher M, Ibraim E, Kalsdorf B, Kaufmann SHE, Kontsevaya I, van Leth F, Mandalakas AM, Maurer FP, Müller M, Nitschkowski D, Olaru ID, Popa C, Rachow A, Rolling T, Rybniker J, Salzer HJF, Sanchez-Carballo P, Schuhmann M, Schaub D, Spinu V, Suárez I, Terhalle E, Unnewehr M, Weiner J 3rd, Goldmann T, Lange C. Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model. Eur Respir J. 2021 Sep 2;58(3):2003492. doi: 10.1183/13993003.03492-2020. PMID: 33574078.

Lange C, Aaby P, Behr MA, Donald PR, Kaufmann SHE, Netea MG, Mandalakas AM. 100 years of Mycobacterium bovis bacille Calmette-Guérin. Lancet Infect Dis. 2021 Sep 7:S1473-3099(21)00403-5. doi: 10.1016/S1473-3099(21)00403-5. Epub ahead of print. PMID: 34506734.

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y. Erratum for: Nat Immunol. 2021 Jan;22(1):2-6. PMID: 34017127

Kay AW, Sandoval M, Mtetwa G, Mkhabela M, Ndlovu B, Devezin T, Sikhondze W, Vambe D, Sibanda J, Dube GS, Stevens RH, Lukhele B, Mandalakas AM. Vikela Ekhaya: a novel, community-based, tuberculosis contact management program in a high burden setting. Clin Infect Dis. 2021 Jul 24:ciab652. doi: 10.1093/cid/ciab652. Epub ahead of print. PMID: 34302733.

Lange C, Chesov D, Konstantynovska O, Mandalakas AM, Udwadia Z. Sorry for the delay. Clin Microbiol Infect. 2021 Jul;27(7):941-943. doi: 10.1016/j.cmi.2021.03.007. Epub 2021 Apr 3. PMID: 33823271; PMCID: PMC8079284.

Spezia-Lindner NJ, Kondapi D, DiNardo AR, Ramaswami R, Chiao E, Clark EH. The Importance of Early Recognition of KSHV-mediated Syndromes: A Case Report. Am J Med. 2021 May 11: S0002-9343(21)00304-1. doi: 10.1016/j.amjmed.2021.04.015. Epub ahead of print. PMID: 33989604.

Kontsevaya I, Lange C, Comella-Del-Barrio P, Coarfa C, DiNardo AR, Gillespie SH, Hauptmann M, Leschczyk C, Mandalakas AM, Martinecz A, Merker M, Niemann S, Reimann M, Rzhepishevska O, Schaible UE, Scheu KM, Schurr E, Abel Zur Wiesch P, Heyckendorf J. Perspectives for systems biology in the management of tuberculosis. Eur Respir Rev. 2021 May 25; 30(160):200377. doi: 10.1183/16000617.0377-2020. PMID: 34039674

Abhimanyu , Ontiveros Carlos O., Guerra-Resendez Rosa S., Nishiguchi Tomoki, Ladki Malik, Hilton Isaac B., Schlesinger Larry S., DiNardo Andrew R. Reversing Post-Infectious Epigenetic-Mediated Immune Suppression. Frontiers in Immunology. 12, 2021: 2093. DOI 10.3389/fimmu.2021.688132. ISSN 1664-3224.  

Mandalakas AM, Hesseling AC, Kay A, Du Preez K, Martinez L, Ronge L, DiNardo A, Lange C, Kirchner HL. Tuberculosis prevention in children: a prospective community-based study in South Africa. Eur Respir J. 2021 Apr 22;57(4):2003028. doi: 10.1183/13993003.03028-2020. PMID: 33122339; PMCID: PMC8060782

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jul;22(7):928. doi: 10.1038/s41590-021-00960-y. Erratum for: Nat Immunol. 2021 Jan;22(1):2-6. PMID: 34017127.

Viola GM, Malek AE, Rosen LB, DiNardo AR, Nishiguchi T, Okhuysen PC, Holland SM, Kontoyiannis DP. Disseminated cryptococcosis and anti-granulocyte-macrophage colony-stimulating factor autoantibodies: An underappreciated association. Mycoses. 2021 Jun;64(6):576-582. doi: 10.1111/myc.13247. Epub 2021 Feb 5. PMID: 33476401.

Jasumback CL, Dlamini Q, Kahari J, Maphalala G, Dlamini MG, Dube GS, DiNardo A, Kirchner HL, Mandalakas A, Kay AW. Laboratory comparison of stool processing methods for Xpert® Ultra. Public Health Action. 2021 Jun 21;11(2):55-57. doi: 10.5588/pha.20.0079. PubMed PMID: 34159062; PubMed Central PMCID: PMC8202631. 

Vonasek B, Ness T, Takwoingi Y, Kay AW, van Wyk SS, Ouellette L, Marais BJ, Steingart KR, Mandalakas AM. Screening tests for active pulmonary tuberculosis in children. Cochrane Database Syst Rev. 2021 Jun 28;6:CD013693. doi: 10.1002/14651858.CD013693.pub2. Review. PubMed PMID: 34180536; PubMed Central PMCID: PMC8237391. 

Marais BJ, Verkuijl S, Casenghi M, Triasih R, Hesseling AC, Mandalakas AM, Marcy O, Seddon JA, Graham SM, Amanullah F. Paediatric tuberculosis - new advances to close persistent gaps. Int J Infect Dis. 2021 Mar 11:S1201-9712(21)00088-6. doi: 10.1016/j.ijid.2021.02.003. Epub ahead of print. PMID: 33716193.

Heyckendorf J, Marwitz S, Reimann M, Avsar K, DiNardo A, Günther G, Hoelscher M, Ibraim E, Kalsdorf B, Kaufmann SHE, Kontsevaya I, van Leth F, Mandalakas AM, Maurer FP, Müller M, Nitschkowski D, Olaru ID, Popa C, Rachow A, Rolling T, Rybniker J, Salzer HJF, Sanchez-Carballo P, Schuhmann M, Schaub D, Spinu V, Suárez I, Terhalle E, Unnewehr M, Weiner J 3rd, Goldmann T, Lange C. Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model. Eur Respir J. 2021 Feb 11:2003492. doi: 10.1183/13993003.03492-2020. Epub ahead of print. PMID: 33574078.

Vonasek B, Kay A, Devezin T, Bacha JM, Kazembe P, Dhillon D, Dlamini S, Haq H, Thahane L, Simon K, Matshaba M, Sanders J, Minde M, Wanless S, Nyasulu P, Mandalakas A. Tuberculosis symptom screening for children and adolescents living with HIV in six high HIV/TB burden countries in Africa. AIDS. 2021 Jan 1;35(1):73-79. doi: 10.1097/QAD.0000000000002715. PMID: 33048868; PMCID: PMC7752241.

Ness TE, Streatfield AE, Simelane T, Korsa A, Dlamini S, Guffey D, Lukhele B, Kay AW. Evaluating antibiotic use and developing a tool to optimize prescribing in a family-centered HIV clinic in Eswatini. PLoS One. 2021 Jan 7;16(1):e0244247. doi: 10.1371/journal.pone.0244247. PMID: 33411762; PMCID: PMC7790297.

DiNardo AR, Netea MG, Musher DM. Postinfectious Epigenetic Immune Modifications - A Double-Edged Sword. N Engl J Med. 2021 Jan 21;384(3):261-270. doi: 10.1056/NEJMra2028358. PMID: 33471978.

Viola GM, Malek AE, Rosen LB, DiNardo AR, Nishiguchi T, Okhuysen PC, Holland SM, Kontoyiannis DP. Disseminated Cryptococcosis and Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies: An Underappreciated Association. Mycoses. 2021 Jan 21. doi: 10.1111/myc.13247. Epub ahead of print. PMID: 33476401.

Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O'Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712.

2020

Kay AW, Thivalapill N, Skinner D, Dube GS, Dlamini N, Mzileni B, Fuentes P, Ustero P, Adams LV, Mandalakas AM. Predictors of suboptimal adherence to isoniazid preventive therapy among adolescents and children living with HIV. PLoS One. 2020 Dec 17;15(12):e0243713. doi: 10.1371/journal.pone.0243713. PMID: 33332462; PMCID: PMC7746166.

Mandalakas AM, Kay AW, Bacha JM, Devezin T, Golin R, Simon KR, Dhillon D, Dlamini S, DiNardo A, Matshaba M, Sanders J, Thahane L, Amuge PM, Ahmed S, Sekadde MP, Fida NG, Lukhele B, Chidah N, Damba D, Mhango J, Chodota M, Matsoso M, Kayabu A, Wanless RS, Schutze GE. Tuberculosis among Children and Adolescents at HIV Treatment Centers in Sub-Saharan Africa. Emerging Infectious Diseases. 2020 Dec; 26(12). doi: 10.3201/eid2612.202245. PMID: 33219815.

“WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection” https://www.who.int/publications/i/item/who-consolidated-guidelines-on-tuberculosis-module-3-diagnosis---rapid-diagnostics-for-tuberculosis-detection

Lange C, Aarnoutse R, Chesov D, Van Crevel R, Gillespie SH, Grobbel HP, Kalsdorf B, Kontsevaya I, Van Laarhoven A, Nishiguchi T, Mandalakas AM, Merker M, Niemann S, Köhler N, Heyckendorf J, Reimann M, Ruhwald M, Sanchez-Carballo P, Schwudke D, Waldow F, DiNardo A. Perspective for Precision Medicine for Tuberculosis. Frontiers in Immunology, section Inflammation. Mini Review. 

Kay AW, González Fernández L, Takwoingi Y, Michael Eisenhut, Anne K Detjen, Karen R Steingart, Anna M Mandalakas. Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children. Cochrane Database Syst Rev. 2020;8:CD013359. Published 2020 Aug 27. doi:10.1002/14651858.CD013359.pub2 

Kay AW, Ness TE, Martinez L, Mandalakas AM. It Ain't Over Till It's Over: The Triple Threat of COVID-19, TB, and HIV [published online ahead of print, 2020 Aug 31]. Am J Trop Med Hyg. 2020;10.4269/ajtmh.20-1089. doi:10.4269/ajtmh.20-1089.

Thivalapill N, Jasumback CL, Perry SH, Dlamini L, Matsenjwa M, Masangane ZT, Mavimbela M, Mthethwa N, Kirchner HL, Mphaya J, Lukhele B, Mandalakas A, Kay AW. Predicting Sexually Transmitted Infections Among HIV+ Adolescents and Young Adults: A Novel Risk Score to Augment Syndromic Management in Eswatini. J Acquir Immune Defic Syndr. 2020 Sep 15. doi: 10.1097/QAI.0000000000002512. Epub ahead of print. PMID: 32947446.

Gatchalian SR, Agathis NT, Castillo-Carandang NT, Gunter SM, Murray KO, Mandalakas AM. Design and Evaluation of Risk Assessment Tools to Identify Pediatric Tuberculosis Infection in Bohol, the Philippines, a Low-HIV- and High-TB-Burden Setting. Am J Trop Med Hyg. 2020 Sep 21. doi: 10.4269/ajtmh.20-0244. Epub ahead of print. PMID: 32975174.

Ventura MJ, Guajardo E, Clark EH, Bhairavarasu K, Kherallah RY, DiNardo AR, Ye X, Piedra PA, Atmar RL, Agarwal SK. Correspondence on 'Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort' by Pouletty et al. Ann Rheum Dis. 2020 Sep 25:annrheumdis-2020-218959. doi: 10.1136/annrheumdis-2020-218959. Epub ahead of print. PMID: 32978236.

Russell EA, Tsai C, Linton JM. Children in Immigrant Families: Advocacy within and beyond the Pediatric Emergency Department [published online ahead of print, 2020 Sep 9]. Clin Pediatr Emerg Med. 2020;21(2):100779. doi:10.1016/j.cpem.2020.100779

Vonasek B, Kay A, Devezin T, Bacha JM, Kazembe P, Dhillon D, Dlamini S, Haq H, Thahane L, Simon K, Matshaba M, Sanders J, Minde M, Wanless S, Nyasulu P, Mandalakas A. Tuberculosis symptom screening for children and adolescents living with HIV in six high HIV/TB burden countries in Africa. AIDS. 2020 Oct 20. doi: 10.1097/QAD.0000000000002715. Epub ahead of print. PMID: 33048868.

Sandoval M, Swamy P, Kay AW, Ustero P, Dube GS, Hlophe-Dlamini H, Mandalakas AM. Distinct Risk Factors for Clinical and Bacteriologically Confirmed Tuberculosis among Child Household Contacts in a High-Burden Setting. Am J Trop Med Hyg. 2020 Sep 28. doi: 10.4269/ajtmh.20-0522. Epub ahead of print. PMID: 32996456.

Lange C, Aarnoutse R, Chesov D, van Crevel R, Gillespie SH, Grobbel HP, Kalsdorf B, Kontsevaya I, van Laarhoven A, Nishiguchi T, Mandalakas A, Merker M, Niemann S, Köhler N, Heyckendorf J, Reimann M, Ruhwald M, Sanchez-Carballo P, Schwudke D, Waldow F, DiNardo AR. Perspective for Precision Medicine for Tuberculosis. Front Immunol. 2020 Oct 8;11:566608. doi: 10.3389/fimmu.2020.566608. PMID: 33117351; PMCID: PMC7578248.

Thivalapill N, Simelane T, Mthethwa N, Dlamini S, Lukhele B, Okello V, Kirchner HL, Mandalakas AM, Kay AW. Transition to dolutegravir is associated with an increase in the rate of BMI change in a cohort of virally suppressed adolescents. Clin Infect Dis. 2020 Oct 29:ciaa1652. doi: 10.1093/cid/ciaa1652. Epub ahead of print. PMID: 33119739.

Mandalakas AM, Hesseling AC, Kay A, Du Preez K, Martinez L, Ronge L, DiNardo A, Lange C, Kirchner HL. Tuberculosis prevention in children: A prospective community based study in South Africa. Eur Respir J. 2020 Oct 29:2003028. doi: 10.1183/13993003.03028-2020. Epub ahead of print. PMID: 33122339.

Challenging the management of drug-resistant tuberculosis -Authors' reply. Lancet. 2020. Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR Jr. 395(10226):783–784. doi:10.1016/S0140-6736(20)30055-6 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30052-0/fulltext

2017

Why being an expert - despite xpert -remains crucial for children in high TB burden settings. Bacha JM, Ngo K, Clowes P, Draper HR, Ntinginya EN, DiNardo A, Mangu C, Sabi I, Mtafya B, Mandalakas AM. BMC Infect Dis. 2017 Feb 6; 17(1):123. PMID: 28166728

Clinical Application of Interferon-γ Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence. Lange C, Mandalakas AM, Kalsdorf B, Denkinger CM, Sester M. Pathog Immun. 2016;1(2):308-329. PMID: 28217762

Tuberculosis Treatment Outcomes among HIV/TB Co-Infected Children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Network. Carlucci JG, Blevins M, Kipp AM, Lindegren ML, Du QT, Renner L, Reubenson G, Ssali J, Yotebieng M, Mandalakas AM, Davies MA, Ballif M, Fenner L, Pettit AC; International Epidemiology Databases to Evaluate AIDS (IeDEA) Network. J Acquir Immune Defic Syndr. 2017 Feb 20. PMID:  28234689

Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity". Van der Zalm MM, van Soelen N, Mandalakas AM, Jacobsen M, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, Hesseling AC. Pediatr Infect Dis J. 2017 Feb; 36(2):241-242. PMID: 28079838.

School and household tuberculosis contact investigations in Swaziland: Active TB case finding in a high HIV/TB burden setting. Ustero, P., Kay, A., Ngo, K., Golin, R., Tsabedze, B., Mzileni, B., Glickman, J., Xaba, M.W., Mavimbela, G., Mandalakas, A. (Accepted May 2017, PLOS ONE).

2016

HIV Progression Perturbs the Balance of the Cell-Mediated and Anti Inflammatory Adaptive and Innate Mycobacterial ImmuneResponse. DiNardo AR, Mandalakas AM, Maphalala G, Mtetwa G, Mndzebele T, Ustero P, Hlatshwayo M, Mace EM, Orange JS, Makedonas G. Mediators Inflamm. 2016;2016:1478340. Epub 2016 Mar 2. doi: 10.1155/2016/1478340.

1,2,3 (years) …and you’re out. The End of a 123-year Historic Era. DiNardo AR, Lange C, Mandalakas AM. Clinical Infectious Disease. 2016 Feb 2. PMID: 26839384

The Effect of Deworming on Tests of Tuberculosis Infection in Children with Recent Tuberculosis Exposure - A Randomized Controlled Trial. Van der Zalm MM, van Soelen N, Mandalakas AM, Jacobsen M, Detjen AK, Marx FM, Grewal H, Cotton MF, Walzl G, Hesseling AC. Pediatr Infect Dis J. 2016 Feb 29.

Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation. DiNardo AR, Mace EM, Lesteberg K, Cirillo JD, Mandalakas AM, Graviss EA, Orange JS, Makedonas G.  J Infect Dis. 2016 Aug 1;214(3):479-88. doi: 10.1093/infdis/jiw156. PMID: 27389351

Culture is an imperfect and heterogeneous reference standard in pediatric tuberculosis. DiNardo AR, Detjen A, Ustero P, Ngo K, Bacha J, Mandalakas AM. Tuberculosis (Edinb). 2016 Sep 28. pii: S1472-9792(16)30405-X. doi: 10.1016/j.tube.2016.09.021.

Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases. Fox GJ, Schaaf HS, Mandalakas A, Chiappini E, Zumla A, Marais BJ. Clin Microbiol Infect. 2016 Aug 31. PMID: 27592087

Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries. Charles MK, Lindegren ML, Wester CW, Blevins M, Sterling TR, Dung NT, Dusingize JC, Avit-Edi D, Durier N, Castelnuovo B, Nakigozi G, Cortes CP, Ballif M, Fenner L; International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration (including Mandalakas A). PLoS One. 2016 Apr 13;11(4):e0153243. PMID: 27073928

2015

Use of string test and stool specimens to diagnose pulmonary tuberculosis. DiNardo AR, Hahn A, Leyden J, Stager C, Baron EJ, Graviss EA, Mandalakas AM, Guy E. Int J Infect Dis. 2015 Dec;41:50-2. Epub 2015 Oct 30. doi: 10.1016/j.ijgo.2015.06.062.