Sourav K. Bose, MD, MBA, MSc

Dr. Sourav Bose is a Pediatric Surgeon at Texas Children’s Hospital who specializes in the surgical care of infants and children with congenital and complex conditions. His clinical interests include neonatal and thoracic surgery, robotic surgery, advanced laparoscopy and other minimally invasive approaches. He also has a particular interest in fluorescence-guided surgery and emerging technologies that can make operations more precise and less invasive.

Dr. Bose’s approach to surgery is shaped by his work as both a surgeon and a scientist. He is particularly interested in bringing new technologies and discoveries into the operating room to improve how complex congenital conditions are treated. His research program focuses on fetal and neonatal disease, including congenital diaphragmatic hernia and abnormal lung development, and explores new therapeutic strategies ranging from fetal intervention to RNA-based therapies, nanoparticles and gene editing.

Dr. Bose is an active contributor to the advancement of pediatric and fetal surgery, and his work has been recognized and presented at leading national and international surgical and scientific meetings. Across his clinical and research work, his goal is to provide children with complex surgical conditions the most precise, innovative and thoughtful care possible while minimizing the burden of treatment on them and their families.

Personal Statement

When a child needs surgery, I believe families deserve to understand all of their options and to have a surgeon who will think carefully about which approach is right for their child. I spend time talking with families about what we know, what we don't know and why I am recommending a particular path. For complex diagnoses, I welcome families seeking another perspective or wanting to understand whether a minimally invasive or newer approach may be an option for their child.

My goal is to solve the surgical problem while minimizing the impact of treatment whenever possible. I have a particular interest in robotic surgery, advanced laparoscopy, fluorescence-guided surgery, and other minimally invasive techniques that allow us to approach increasingly complex operations with greater precision. I also work closely with specialists across Texas Children's to bring together the right expertise when a child needs more than one perspective.

What continues to drive me is the belief that we can make the care we provide better. My research in fetal and neonatal therapy is an extension of that philosophy; namely, asking whether we can treat disease earlier, operate more precisely, or develop options for conditions where our current treatments are not good enough.

I want families who come to see me to leave with a clear understanding of their child's condition and the options available to them. Sometimes that means surgery, sometimes it means a minimally invasive approach and sometimes the right answer is not to operate at all. My job is to help families make that decision thoughtfully and, if surgery is the right choice, to provide the best operation we can.

Clinical Interests

Congenital diaphragmatic hernia (CDH), biliary atresia, thoracic outlet syndrome, congenital lung disease, tracheo-esophageal and foregut disorders, neonatal surgery, fetal surgery and fetal intervention, ECMO, robotic surgery, minimally invasive surgery

Education

Organizations

Board Certification

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research interests

Fetal and neonatal therapeutics; congenital diaphragmatic hernia and pulmonary hypoplasia; fetal lung development and mechanobiology; fetal intervention; gene editing, RNA and nanoparticle-based therapies for congenital disease; human tissue models; fluorescence-guided surgery and surgical innovation

Bose SK, White BM, Kashyap MV, et al. In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nature Communications, 2021;12:4291. doi:10.1038/s41467-021-24443-8

Palanki R, Riley JS, Bose SK, et al. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 2024;121(32):e2400783121. doi:10.1073/pnas.2400783121

Palanki R, Bose SK, Dave A, et al. Ionizable lipid nanoparticles for therapeutic base editing of congenital brain disease. ACS Nano, 2023;17(14):13594–13610. doi:10.1021/acsnano.3c02268

Guerra ME, Arai T, Joyeux L, Baxter CC, Bose S, et al. Intra-Abdominal Bowel Dilation in Experimental Gastroschisis is Associated with a Modifiable Transcriptomic Program of Intestinal Dysfunction. bioRxiv, 2026. Preprint. doi:10.64898/2026.05.29.728798

Bose SK, White BM, Cook RC, et al. Enteral nutrition support for infants with pulmonary hypoplasia: A qualitative evaluation of caregiver and provider perspectives. Nutrition in Clinical Practice, 2022;37(4):955–965. doi:10.1002/ncp.10867

Swingle KL, Billingsley MM, Bose SK, et al. Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. Journal of Controlled Release, 2022;341:616–633. doi:10.1016/j.jconrel.2021.10.031

Riley RS, Kashyap MV, Billingsley MM, White BM, Alameh MG, Bose SK, et al. Ionizable lipid nanoparticles for in utero mRNA delivery. Science Advances, 2021;7(3):eaba1028. doi:10.1126/sciadv.aba1028