Updates

Pathology Outreach

Pediatric Cancer Genomics and Molecular Pathology

The Division of Genomic Medicine services include genetic and genomic testing of cancer, as well as inherited conditions. The Division offers a diverse array of molecular genomic diagnostic services to assist with accurate diagnosis, risk-stratification, disease monitoring, as well as for matching the genetic profiles of individual tumors to appropriate targeted therapies. The goal of the Division is to provide clinicians and pathologists with comprehensive molecular and genomic diagnostic services beyond performing the tests, including consultation, appropriate molecular test selection as well as integrated results interpretation.

The Division includes the Cancer Cytogenetics, Cancer Genomics, and Molecular Oncology laboratories. Tests offered range from conventional cytogenetics and DNA microarray-based cytogenomic profiling, DNA and RNA-based next-generation sequencing (NGS) panels for mutations, copy number variation (CNV) and gene fusions, to targeted testing strategies, including fluorescence in situ hybridization (FISH), and single gene/target testing.

Contact

Renee Webb
Division of genomic Medicine
Texas Children's Hospital
pathologyoutreachmgp@texaschildrens.org
Phone: 832-824-5032

Test services and requisition forms are provided below:

Solid Tumor Comprehensive Panel

Solid Tumor Mutation Panel

Solid Tumor Fusion Panel

Heme Mutation Panel

Cancer Microarray - Tissue

Cancer Microarray - Blood/Bone Marrow

Genome-wide assay utilizing the Affymetrix OncoScan™ Array with Molecular Inversion Probe (MIP) technology for focal and large CNV and loss of heterozygosity (LOH).

End-Point RT-PCR Assays for Solid Tumors

  • Ewing's Family of Tumors t(11;22) EWSR1/FLI1 & t(21;22) EWSR1/ERG
  • Desmoplastic Small Round Cell Tumor t(11;22) EWSR1/WT1
  • Clear Cell Sarcoma (Soft Part Melanoma) t(12;22) EWSR1/ATF1
  • Angiomatoid Fibrous Histiocytoma t(2;22) EWSR1/CREB1
  • Unclassified/Undifferentiated Sarcoma inv(X) BCOR/CCNB3
  • Synovial Sarcoma t(X;18) SS18(SYT)/SSX
  • Myxoid Liposarcoma t(12;16) FUS/DDIT3(CHOP)
  • Low-grade Fibromyxoid Sarcoma t(7;16) FUS/CREB3L2 & t(11;16) FUS/CREB3L1
  • Alveolar Rhabdomyosarcoma t(2:13) PAX3/FOXO1(FKHR)
  • Alveolar Rhabdomyosarcoma t(1:13) PAX7/FOXO1(FKHR)
  • Congenital Fibrosarcoma t(12;15) ETV6/NTRK3
  • Alveolar Soft Part Sarcoma t(X;17) ASPSCR1(ASPL)/TFE3
  • Anaplastic Large Cell Lymphoma t(2;5)  NPM1/ALK
  • Dermatofibrosarcoma Protuberans t(17;22) COL1A1/PDGFB
  • Molecular Genetics Test Requisition

Real-Time PCR Assays

  • BCR/ABL p190 & p210 Quantitation
  • PML/RARA Quantitation
  • BRAF V600E Detection
  • BRAF V600E Quantitation
  • Xpert HemosIL Factor II & Factor V Assay 
  • Molecular Genetics Test Requisition

FISH Assays

  • 12q15 (MDM2) region amplification
  • EWSR1 Rearrangement Detection
  • ALK Gene Amplification
  • X/Y Chromosome Enumeration
  • CIC Gene Rearrangement Detection
  • Molecular Genetics Test Requisition

DNA Sequencing / Fragment Analysis Assays

  • Desmoid Fibromatosis CTNNB1 (Beta-Catenin) Exon 3 Mutation Detection
  • ALK Exons 21-28 Mutation Analysis
  • BCOR Internal Tandem Duplication Detection
  • TERT Promoter Mutation Analysis
  • Molecular Genetics Test Requisition