Vaccine Development Chagas Disease
Trypanosoma Cruzi
Trypanosoma cruzi parasite at trypomastigote stage seen in the gut contents of a kissing bug, Triatoma sanguisuga, using dark field microscopy. This particular kissing bug was captured in Conroe, Texas.
Triatoma sanguisuga
Shown here is a kissing bug (specifically in this case Triatoma sanguisuga), the Chagas disease vector--this one was found in Conroe, Texas, and tested positive for the parasite Trypanosoma cruzi.
Selected Publications
- Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice
- Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects
- Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease
- A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease
Therapeutic Nanoparticle Vaccine Against Trypanosoma Cruzi in a Mouse Model of Chagas Disease
See details here about vaccine formulation; kinetics of antigen dispersal; immunogenicity; and therapeutic efficacy: See full poster