Duncan NRI Shubham Singh, Ph.D.
Assistant Professor, Department of Pediatrics, Division of Hematology and Ontology, Baylor College of Medicine
Principal Investigator, Texas Children's Research Institute, Texas Children's Hospital
Principal Investigator, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital
Texas Children's Research Scholar, Texas Children's Hospital
Contact Information:
Email: Shubham.Singh@bcm.edu
Research focus
The Singh Lab investigates how central nervous system acquires, metabolizes, and traffics lipids, and how impaired lipid metabolism drives neurodegeneration.
Get to know Shubham Singh, Ph.D.
The brain is one of the most lipid-rich organs in the human body, yet the mechanisms through which lipids are acquired, distributed, and metabolized in the central nervous system remain elusive.
We are investigating the fundamental principles of lipid metabolism in brain, and elucidating mechanisms through which deregulated lipid metabolism arise and contribute to neurodegenerative diseases like frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease.
A few broad questions our lab is currently pursuing:
What proportion of brain lipids are acquired from the diet versus synthesized locally within the brain?
How does the brain balance glucose utilization between energy production and glycosphingolipid synthesis?
How do neurons and glia coordinate lipid metabolism?
How does genetic variation in lipid metabolism predispose to neurodegeneration?
How do lipid disturbances arise in sporadic neurodegeneration, and can they predict disease risk?
To achieve this, we integrate interdisciplinary tools like LC-MS/MS based lipidomics, metabolic tracing, chemical proteomics, organic synthesis, genetics, molecular biology, biochemistry, iPSCs derived cellular and murine models.
2024 - ATP Scholar (CNS-Metabolism), University of Kentucky.
2022 - Human Frontier Science Postdoctoral Fellowship
2021 - Bluefield Postdoctoral Fellowship
2021 - Sun Pharma Science Scholar Award
2019 - DST-AWSAR Award
2017 - First prize - Intel Python Hackfury (Hackathon), 2019
2012 - DBT Biology Scholarship Award
Click here for a list of Singh Lab publications
