Hanna J. Tadros, MBBCh

Dr. Hanna J. Tadros is a Physician-Scientist and Cardiologist who specializes in the care of children with cardiomyopathy and heart failure and those undergoing and recovering from heart transplantation. He provides both inpatient care at Texas Children’s in the Texas Medical Center as well as outpatient care in cardiomyopathy and transplant clinics. Dr. Tadros has a particular interest in cardiomyopathy genetics, offering families evidence-based interpretation of genetic findings to guide clinical decision-making. A frequent presenter at national and international conferences, he maintains an active research program centered on profiling pediatric heart failure through cutting-edge multi-omic approaches.

Personal Statement

I focus on providing clear, evidence-based care tailored to each patient and family. I believe in open communication and working collaboratively to make informed decisions. My goal is to support patients with cardiomyopathy and heart failure through every step of their care, balancing medical expertise with practical guidance.

Clinical Interests

Cardiomyopathy genetics, cardiomyopathy, heart transplantation

Education

Organizations

Board Certification

American Board of Pediatrics

Honors and awards

2024

Finalist Young Hearts Early Career Investigator Award Competition, American Heart Association Scientific Sessions

2020

Excellence in Medical Teaching Recognition, University of Florida

2019

Young Investigator Award AAP, Section of Cardiology and Cardiac Surgery

2017

Honors, upper division RCSI-Bahrain

2015

Bronze Medal for Academic Achievements, Intermediate Cycle RCSI Bahrain

2014

Mentor’s Choice Award for Scientific Writing & Best Intern Center for Reproductive Medicine, Cleveland Clinic, OH 

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research interests

High resolution RNA sequencing, variant interpretation, multi-omics

Yang Q*, Tadros HJ*, Sun B, Bidzimou MT, Ezekian JE, Li F, Ludwig A, Wehrens XHT, Landstrom AP. Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade. JACC Basic to Translational Science, 2023. doi:10.1016/j.jacbts.2023.07.008 *Equal first authors/contributed equally

Kurzlechner LM, Kishnani S, Chowdhury S, Atkins SL, Moya-Mendez ME, Parker LE, Rosamilia MB, Tadros HJ, Pace LA, Patel V, Chahal CAA, Landstrom AP. DiscoVari: A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes. Circulation: Genomic and Precision Medicine, 2023 Jul 6:e003911. doi: 10.1161/CIRCGEN.122.003911. Epub ahead of print. PMID: 37409478

Tadros HJ, Doan TT, Pednekar AS, Masand PM, Spinner JA, Schlingmann TR, Pignatelli R, Noel CV, Wilkinson JC. Left ventricular non-compaction in paediatrics: a novel semi-automated imaging technique bridging imaging findings and clinical outcomes. European Heart Journal-Cardiovascular Imaging, 2022 Nov 28:jeac226. doi: 10.1093/ehjci/jeac226. Epub ahead of print. PMID: 36441164

Tadros HJ, Choudhry S, Kearney DL, Hope K, Yesso A, Miyake CY, Price J, Spinner J, Tunuguntla H, Puri K, Dreyer W, Denfield SW. Arrhythmogenic cardiomyopathy is under-recognized in end-stage pediatric heart failure: A 36-year single-center experience. Pediatric Transplantation, 2022 Nov 30:e14442. doi: 10.1111/petr.14442. Epub ahead of print. PMID: 36451335

Tadros HJ, Life CS, Garcia G, Pirozzi E, Jones EG, Datta S, Parvatiyar MS, Chase PB, Allen HD, Kim JJ, Pinto JR, Landstrom AP. Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hotspots that are associated with worse clinical outcomes. Journal of Molecular and Cellular Cardiology, 2020; 142:118-125

Reinoso TR, Landim-Vieira M, Shi Y, Johnston JR, Chase PB, Parvatiyar MS, Landstrom AP, Pinto JR, Tadros HJ. A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. Journal of Muscle Research and Cell Motility, 2021  Jun;42(2):323-342. doi: 10.1007/s10974-020-09592-5. Epub 2020 Nov 11. PMID: 33179204; PMCID: PMC8110610

Daily-Shwartz A*, Tadros HJ*, Azamian MS, Lalani SR, Morris SA, Allen HD, Kim JJ, Landstrom AP. Copy number variants of undetermined significance are not associated with worse clinical outcomes in hypoplastic left heart syndrome. Journal of Pediatrics. 2018; 202:206-211.e2. *Equal first authors/contributed equally