Dwight M. Diaz Chambers, MD, PhD

Dr. Diaz Chambers is a physician scientist interested in metabolic health, obesity, and how the brain helps to coordinate appetite and metabolism. He joined Baylor College of Medicine and Texas Children's in 2026. His previous research studies include mechanisms of how GLP-1 agonist medications work in the brain and novel genetic conditions that cause obesity to understand how cells translate their mechanical environment into genetic programs.  

Dr. Diaz Chambers is a native of Nashville, TN and was a long-time resident of Atlanta and Boston before moving to the Houston area.

Personal Statement

I believe that we live in a very challenging and very hopeful time with respect to our metabolism and health. My focus is on providing compassionate, high-quality care to children with endocrine diseases and on pushing forward the boundaries of what we know to help continue to improve this care. 

Clinical Interests

Type 2 diabetes, obesity, metabolism

Education

Organizations

Board Certification

Honors and awards

2022

Frederick H. Lovejoy Jr Teaching Award, Boston Children's Hospital

2020

Alpha Omega Alpha Academic Honor Society

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research interests

Central mechanisms of obesity and metabolism regulation, obesity and mental health, obesity in adolescence

Chambers DM, Moretti L, Zhang JJ, Cooper SW, Chambers DM, Santangelo PJ, Barker TH. LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol. J Biol Chem. 2018 Oct 12;293(41):15867-15886. doi: 10.1074/jbc.RA118.003658. Epub 2018 Aug 14. PMID: 30108174; PMCID: PMC6187619.
 

Kong D, Li HS, Liu B, Zhang QP, Jin Y, Chambers D, Colgan L, Kang H, Passarelli J, Mzaouakk G, Sun S, Yang Y, Clish C, Greenberg A, Yasuda R. Acsl4-mediated Lipid Homeostasis Orchestrates Synaptic and Cognitive Plasticity. Res Sq [Preprint]. 2026 Apr 28:rs.3.rs-7437638. doi: 10.21203/rs.3.rs-7437638/v1. PMID: 42094061; PMCID: PMC13142639.
 

Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh CR, Chambers DM, von Beck K, Li W, Segura T, Midwood KS, Torres M, Barker TH. Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. Matrix Biol. 2019 Sep;82:86-104. doi: 10.1016/j.matbio.2019.04.002. Epub 2019 Apr 17. PMID: 31004743; PMCID: PMC7168757.
 

Kandaswamy S, Jain S, Chambers DD, Wilcox WR, Agha BS, Dennis H, Brown SP, Orenstein EW. Clinical Decision Support Aiming to Accelerate Triage and Time to Dextrose-Containing IV Fluids in the ED for Children with Severe Metabolic Conditions. Appl Clin Inform. 2025 Aug;16(4):1053-1059. doi: 10.1055/a-2666-4737. Epub 2025 Sep 11. PMID: 40935359; PMCID: PMC12425614.
 

Bongiorno T, Gura J, Talwar P, Chambers D, Young KM, Arafat D, Wang G, Jackson-Holmes EL, Qiu P, McDevitt TC, Sulchek T. Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures. PLoS One. 2018 Mar 8;13(3):e0192631. doi: 10.1371/journal.pone.0192631. PMID: 29518080; PMCID: PMC5843178.
 

Kovari DT, Wei W, Chang P, Toro JS, Beach RF, Chambers D, Porter K, Koo D, Curtis JE. Frustrated Phagocytic Spreading of J774A-1 Macrophages Ends in Myosin II-Dependent Contraction. Biophys J. 2016 Dec 20;111(12):2698-2710. doi: 10.1016/j.bpj.2016.11.009. PMID: 28002746; PMCID: PMC5194617.