Katri V. Typpo, MD, MPH

Dr. Typpo is Professor of Pediatrics and Chief of the Division of Pediatric Critical Care at Baylor College of Medicine and Texas Children's Hospital. She completed pediatric residency and pediatric critical care fellowship training at Baylor College of Medicine and Texas Children's Hospital and returned to Houston in September 2023. In her clinical practice she specializes in the care of children experiencing critical illness. She utilizes evidence-based practices and focuses on providing family-centered care. In addition to clinical duties she maintains an active program of research with the goal of improving provision of critical care to children.

She began her career examining the epidemiology of multiple organ dysfunction syndrome (MODS) during pediatric critical illness in large clinical databases. She completed a health services research fellowship at the Houston VA HSRD Center of Excellence in Houston, TX while pursuing her Master of Public Health (MPH) degree at UT Houston, and was an investigator in the division of Health Policy and Quality. She was an assistant professor of pediatrics at Baylor College of Medicine and faculty in the pediatric intensive care unit at Texas Children’s Hospital before moving to Arizona in 2009. At the University of Arizona, she transitioned to a career in clinical and translational research under the mentorship of Dr. Fayez Ghishan to better understand how nutritional strategies influence the gut microbiome, intestinal barrier functions, organ dysfunction, and other patient outcomes.

She is currently funded by the NIH to study how nutritional strategies influence the gut microbiome, lung inflammation, and other organ function during pediatric critical illness. Through her research, Dr. Typpo hopes to develop nutritional strategies which will improve outcomes of critical illness for her patients.

Personal Statement

I am deeply committed to providing high-quality, evidence-based care to my patients and their families. Family-centered care is at the heart of my clinical practice. I strive to treat patients and families with compassionate care and shared decision making, to personalize care to achieve the best possible outcome aligned with each family’s values.

 

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Clinical Interests

Optimal nutrition during pediatric critical illness

 

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Organizations

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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

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Highlights

Research interests

Nutrition, gut microbiome, congenital heart disease, acute lung injury

Dionne A, Friedman KG, Young CC, Newhams MM, Kucukak S, Jackson AM, Fitzgerald JC, Smallcomb LS, Heidemann S, McLaughlin GE, Irby K, Bradford TT, Horwitz SM, Loftis LL, Soma VL, Rowan CM, Kong M, Halasa NB, Tarquinio KM, Schwarz AJ, Hume JR, Gertz SJ, Clouser KN, Carroll CL, Wellnitz K, Cullimore ML, Doymaz S, Levy ER, Typpo KV, Lansell AN, Butler AD, Kuebler JD, Zambrano LD, Campbell AP, Patel MM, Randolph AG, Newburger JW; Overcoming COVID‐19 Investigators. Tachyarrhythmias During Hospitalization for COVID-19 or Multisystem Inflammatory Syndrome in Children and Adolescents. J Am Heart Assoc. 2022 Oct 18;11(20):e025915. doi: 10.1161/JAHA.122.025915. Epub 2022 Oct 17. PMID: 36250670; PMCID: PMC9673680.

Price AM, Olson SM, Newhams MM, Halasa NB, Boom JA, Sahni LC, Pannaraj PS, Irby K, Bline KE, Maddux AB, Nofziger RA, Cameron MA, Walker TC, Schwartz SP, Mack EH, Smallcomb L, Schuster JE, Hobbs CV, Kamidani S, Tarquinio KM, Bradford TT, Levy ER, Chiotos K, Bhumbra SS, Cvijanovich NZ, Heidemann SM, Cullimore ML, Gertz SJ, Coates BM, Staat MA, Zinter MS, Kong M, Chatani BM, Hume JR, Typpo KV, Maamari M, Flori HR, Tenforde MW, Zambrano LD, Campbell AP, Patel MM, Randolph AG; Overcoming Covid-19 Investigators. BNT162b2 Protection against the Omicron Variant in Children and Adolescents. N Engl J Med. 2022 May 19;386(20):1899-1909. doi: 10.1056/NEJMoa2202826. Epub 2022 Mar 30. PMID: 35353976; PMCID: PMC9006785.

Typpo KV, Irving SY, Prince JM, Pathan N, Brown AM; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Gastrointestinal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S53-S58. doi: 10.1542/peds.2021-052888H. PMID: 34970680; PMCID: PMC9662164.

Srinivasan V, Hasbani NR, Mehta NM, Irving SY, Kandil SB, Allen HC, Typpo KV, Cvijanovich NZ, Faustino EVS, Wypij D, Agus MSD, Nadkarni VM; Heart and Lung Failure-Pediatric Insulin Titration (HALF-PINT) Study Investigators. Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial. Pediatr Crit Care Med. 2020 Mar;21(3):213-221. PMID: 31577692; PMCID: PMC7060827.

Irving SY, Daly B, Verger J, Typpo KV, Brown AM, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V; Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. Crit Care Med. 2018 Nov;46(11):e1029-e1039. doi: 10.1097/CCM.0000000000003351. PMID: 30095495; PMCID: PMC6185775.

Typpo KV, Watson RS, Bennett TD, Farris RW, Spaeder MC, Petersen NJ. Outcomes of Day 1 Multiple Organ Dysfunction Syndrome in the Pediatric Intensive Care Unit. Pediatr Crit Care Med. 2019 Oct;20(10):914-922. PMCID: PMC7336888.

Typpo KV, Larmonier CB, Deschenes J, Redford D, Kiela PR, Ghishan FK. Clinical characteristics associated with postoperative intestinal epithelial barrier dysfunction in children with congenital heart disease. Pediatr Crit Care Med. 2015 Jan;16(1):37-44. doi: 10.1097/PCC.0000000000000256. PMID: 25162512; PMCID: PMC4286428.