Skip to main content

Virtual visit appointments available 7 days a week from 9:00am to 11:00pm. Learn More

COVID-19 Updates

COVID-19 Updates: Get the latest on vaccine information, in-person appointments, virtual visits and more. Learn More


Texas Medical Center

Phone: 832-822-2100
Fax: 832-825-4294


6701 Fannin Street
Suite 1560
Houston, TX 77030

Fernando Scaglia, MD

Professor, Department of Molecular and Human Genetics

Baylor College of Medicine


School Education Degree Year
Emory University School of Medicine Fellowship Medical Genetics 1998
Emory University School of Medicine Residency Pediatrics 1995
Emory University School of Medicine Internship Pediatrics 1993
Universidad Nacional De La Plata - Argentina Medical School Doctor of Medicine 1989


Clinical Interests:

Mitochondrial cytopathies, other inborn errors of metabolism

Research Interests:

I have been involved in clinical research studies that are evaluating nitric oxide flux and production in children with MELAS syndrome. This mitochondrial syndrome is associated with metabolic stroke episodes and it is thought that these episodes could reflect the effect of nitric oxide depletion in the small vasculature. By assessing nitric oxide production and the effect of arginine and citrulline supplementation in these children, potential therapeutic strategies could be offered to them. Furthermore, I am also interested in conducting glucose kinetic studies to assess the glucose metabolism and to better understand the mechanisms of diabetes in patients with this syndrome.

Another project where I am involved is the identification of nuclear gene defects of pediatric mitochondrial disorders and in particular mitochondrial DNA depletion syndromes through exome sequencing. Other research interests focus on a natural history study of mitochondrial disorders in collaboration with other centers in United States of America and Canada.


Organization Name Role
American Society of Human Genetics Member
Society for the Study of Inherited Metabolic Disorders Member
Society of Inherited Metabolic Disorders Member
Society of Pediatric Research Member
United Mitochondrial Disease Foundation Elected Member, Scientific and Medical Advisory Board

Selected Publications

El-Hattab AW, Emrick LT, Craigen WJ, Scaglia F. Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Molecular Genetics andMetabolism 2012 Jul 6. [Epub ahead of print].

* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.