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Department
LocationTexas Medical Center
Specialty
Cancer and Hematology
Phone: 832-824-4693
Fax: 832-825-4732
Email
cmrooney@texaschildrens.org
Address
1102 Bates Street, Suite 1570
Houston, TX 77030
Research Laboratory
Cliona Rooney, PhD
Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
Professor, Department of Molecular Virology and Microbiology, Baylor College of Medicine
Professor, Department of Immunology, Baylor College of Medicine
Thomas J. Rosenbalm, M.D., Presidential Endowed Chair, Baylor College of Medicine
Education
| School | Education | Degree | Year |
|---|---|---|---|
| University of Birmingham, England | Post-doctoral Fellow | ||
| University of Bristol, England | Post-doctoral Fellow | ||
| University of Cambridge, England | University | Doctor of Philosophy | |
| Yale University | Post-doctoral Fellow |
About
Dr. Cliona Rooney’s research interests are immunotherapies for virus and non-virus-associated malignancies and diseases. In protocols developed with Dr. Helen Heslop, Dr. Malcolm Brenner, Dr. Stephen Gottschalk and Dr. Catherine Bollard, about 150 patients have received EBV or antigen-specific cytotoxic T-cells. These have prevented and cured EBV-associated lymphoma in BMT recipients produced mixed tumor responses, including complete remissions in patients with relapsed EBV-positive Hodgkin’s disease and nasopharyngeal carcinoma and have produced clinical remission in chronic-active EBV infections. In the research laboratory, she is developing methods for the activation and expansion of antigen-specific CTLs for the treatment of non-viral cancers, investigating ways to render CTL resistant to immune evasion strategies used by tumor cells to grow in an immunocompetent host and developing means to induce antigen-specific tolerance.
Dr. Cliona Rooney is a member of the Center for Cell and Gene Therapy (CAGT).
Her research interests include:
- Immunotherapies for virus and non-virus-associated malignancies
- EBV, antigen-specific cytotoxic T-cells
- Treatment of non-viral cancers
- Induction of antigen-specific tolerance
Organizations
| Organization Name | Role |
|---|---|
| American Society of Gene Therapy (ASGT) | Member |
| American Society of Virology (ASV) | Member |
| International Association for EBV and Associated Malignant Diseases | Member |
| New York Academy of Sciences (NYAS) | Member |
Research Statement
Dr. Cliona Rooney’s research interests are immunotherapies for virus and non-virus-associated malignancies and diseases. In protocols developed with Dr. Helen Heslop, Dr. Malcolm Brenner, Dr. Stephen Gottschalk and Dr. Catherine Bollard, about 150 patients have received EBV or antigen-specific cytotoxic T-cells. These have prevented and cured Epstein-Barr virus-associated lymphoma in bone marrow transplant recipients produced mixed tumor responses, including complete remissions in patients with relapsed EBV-positive Hodgkin’s disease and nasopharyngeal carcinoma and have produced clinical remission in chronic-active EBV infections. In the research laboratory, she is developing methods for the activation and expansion of antigen-specific CTLs for the treatment of non-viral cancers, investigating ways to render CTL resistant to immune evasion strategies used by tumor cells to grow in an immunocompetent host and developing means to induce antigen-specific tolerance.
Dr. Cliona Rooney is a member of the Center for Cell and Gene Therapy (CAGT) and Bone Marrow Transplant / Stem Cell Transplant Program at Texas Children's Cancer Center.
Selected Publications
Awards & Honors
2022 Translational Biology and Molecular Medicine (TBMM) Mentorship Award, Baylor College of Medicine
Language
English
* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.