Everyday Health with Dr. Rossana Malatesta Muncher: C3G/IC-MPGN Progression: Can New C3 Inhibitors Stop the Path to Dialysis?

Rossana Malatesta Muncher, MD, a pediatric nephrologist at Texas Children's and an assistant professor at Baylor College of Medicine in Houston, notes that proteinuria is well documented to correlate with kidney failure progression regardless of the cause of kidney disease. “In C3G, proteinuria is caused by the disease process and later by chronic changes in the kidneys,” she says. “Pegcetacoplan has been shown to significantly decrease this proteinuria. Otherwise, I think it’s too soon to tell if this therapy will be curative or a long-term stabilization strategy.”