Nouf Alsaati, MD, MMSc

Dr. Nouf Alsaati is a Pediatric Allergist and Immunologist with expertise in allergy and in rare and complex immune disorders. She specializes in diagnosing and treating children

with atopic conditions such as asthma, food allergies, environmental allergies and atopic dermatitis, as well as primary immunodeficiencies and immune dysregulation. Her work combines compassionate clinical care with advanced immunologic testing and collaborative, team-based management.

In addition to her clinical practice, Dr. Alsaati is an active investigator whose research focuses on improving the diagnosis and understanding of primary immunodeficiencies. She has published extensively in peer-reviewed journals and is a frequent presenter at national and international conferences. Dr. Alsaati is committed to advancing care for children with immune disorders through research, education, and clinical innovation.

Personal Statement

I am a pediatric allergist–immunologist committed to delivering compassionate, personalized medical care tailored to each patient’s unique immunophenotype. My clinical approach integrates precision immunology, advanced immune diagnostics and close multidisciplinary collaboration to address complex immune-mediated disease. I have a strong interest in leveraging artificial intelligence and machine learning to enhance early disease detection, refine risk stratification and ultimately support prevention strategies in immune disorders. In addition to my work in primary immunodeficiency and immune dysregulation, I am actively involved in the solid organ transplant program at Texas Children’s Hospital, where my role focuses on the prevention and management of antibody- and cell-mediated rejection through immunologic monitoring and targeted immune modulation.

Clinical Interests

Prevent antibody mediated and cellular rejection in solid organ transplant recipients

Education

Organizations

Board Certifications

Honors and awards

Notable oral abstract:  Predictive Model for Aiding in Early Common Variable Immunodeficiency Diagnosis, Clinical Immunology Society Annual Meeting, 2024

Scholarship to pursue post-graduate studies in the United States, King Saud University, 2015-2024

Valedictorian, College of Medicine, King Saud University, 2014

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research interests

Utilization of artificial intelligence to help with early disease detection and prevention

Alsaati N, Penney C, Helbig I, Sullivan KE. A predictive model for identification of pediatric individuals with common variable immunodeficiency through electronic medical records. Journal of Allergy and Clinical Immunology. 2025 Jul;156(1):186-194. doi: 10.1016/j.jaci.2025.02.032. Epub 2025 Mar 7. PMID: 40058414

Alsaati N, Beigel K, Maurer K, Henrickson SE, Knight M, Green A, Giunta V, McGinn DE, Wang B, Crowley TB, McDonald-McGinn DM, Sullivan KE. Follicular Helper T Cells and B Cell Maturation in Patients with 22q11.2 Deletion Syndrome and Recurrent Infections. Journal of Clinical Immunology. 2026 Feb 3. doi: 10.1007/s10875-026-01987-2. Epub ahead of print. PMID: 41629437

Beigel K, Alsaati N, Maurer K, McDonald-McGinn D, Crowley TB, Knight M, Henrickson SE, Bassett AS, Sullivan KE. Single cell RNA-seq analysis of hematopoietic cell types in 22q11.2 deletion syndrome reveals significant changes to non-T cells. Pediatric Allergy and Immunology. 2025 Nov;36(11):e70237. doi: 10.1111/pai.70237. PMID: 41174964

Alsaati N, Grier A, Ochfeld E, McClory S, Heimall J. Hematopoietic stem cell transplantation for primary immunodeficiency. Allergy and Asthma Proceedings. 2024 Sep 1;45(5):371-383. doi: 10.2500/aap.2024.45.240069. PMID: 39294909

Sacta MA, Alsaati N, Spergel J. Anaphylaxis: A 2023 practice parameter update: Major changes in management of anaphylaxis. Annals of Allergy, Asthma, & Immunology. 2024 Feb;132(2):109-110. doi: 10.1016/j.anai.2023.10.027. Epub 2023 Dec 18. PMID: 38108677

John McDonnell, Rebecca Marsh, [and 156 others, including Nouf Alsaati] COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. Journal of Clinical Immunology. 2024 Apr 5;44(4):86. doi: 10.1007/s10875-023-01613-5. PMID: 38578389; PMCID: PMC10997719

Sacco K, Kuehn HS, Kawai T, Alsaati N, Smith L, Davila B, Bundy V, Kuhns DB, Dobbs K, Delmonte O, Notarangelo LD, Rosenzweig SD, Keller MD. A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation. Journal of Clinical Immunology. 2023 Feb;43(2):512-520. doi: 10.1007/s10875-022-01395-2. Epub 2022 Nov 15. PMID: 36378426; PMCID: PMC10362980

Nguyen K, Alsaati N, Le Coz C, Romberg N. Genetic obstacles to developing and tolerizing human B cells. WIREs Mechanisms of Disease. 2022 Jul;14(4):e1554. doi: 10.1002/wsbm.1554. Epub 2022 Apr 5. PMID: 35384409