Seema R. Lalani, MD

Department or Service

Specialty

Genetics

Phone: 832-822-4280
Fax: (832) 825-4294

Contact Information

6621 Fannin
MC CC 1560.00
Houston, TX 77030

Associate Professor, Department of Molecular and Human Genetics

Baylor College of Medicine

Education

School Education Degree Year
Baylor College of Medicine fellowship Genetics 2002
Baylor College of Medicine fellowship Genetics 2001
Pennsylvania State University residency Pediatrics 1999
Pennsylvania State University internship Pediatrics 1997
AGA Kahn Medical College medical school Bachelor of Medicine & Surgery 1994

About Seema Lalani

Clinical Interests:

CHARGE syndrome, clinical use of array-comparative genomic hybridization studies in birth defects including cardiovascular malformations

Research Interests:

I?m interested in the application of molecular cytogenetic diagnostic tools such as array-comparative genomic hybridization (CGH), also known as chromosomal microarray analysis (CMA) in understanding the genetic basis of birth defects. Our laboratory is specifically interested in using CMA as a tool to identify candidate regions involved in cardiac patterning. Clinically significant CVMs occur in 5?8 per 1000 live births, yet, the cause of these malformations is unknown in ~85?90% of cases. Recurrent copy number variations are among the known causes of syndromic CVMs, accounting for an important fraction of cases. Our strategy has been to use array-CGH to identify genomic regions with copy number alterations that could be effectively investigated with candidate gene sequencing in a large cohort of individuals with specific CVM. Using this tool, we have identified genes underlying left ventricular outflow tract obstruction defects and Wolff-Parkinson-White syndrome (WPW). We have performed high-resolution genome-wide DNA copy number analyses in over 700 individuals with CVM and have identified novel loci that are involved in CVM.

We are also interested in studying low-frequency population-specific copy number variations linked to certain traits such as early language delay and autism spectrum disorders.

Organization

Organization Name Role
American Board of Medical Genetics Member
American Society of Human Genetics Member
Scientific Advisory Board, CHARGE Syndrome Foundation Member
Society of Pediatric Research Member

Selected Publications

Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. Journal of Medical Genetics 2009; 46:168-175.