Research

If your child has not been seen before at Texas Children's, schedule an ophthalmology appointment with any of our doctors so they can determine if your child is eligible for a study and refer you to the research department.

For appointments or to refer a patient to a study, please call 832-822-3230 or schedule online.

Trials currently enrolling/actively recruiting

ROP2Y: Enrolling by Invitation

To evaluate long-term ocular and developmental outcomes in subjects originally treated with bevacizumab for severe retinopathy of prematurity in the ROP1 study.

CTX: Cerebrotendinous Xanthomatosis (CTX) Prevalence Study

https://clinicaltrials.gov/ct2/show/NCT02638220

This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.

ATS20: ATS20 Binocular Dig Rush Game Treatment for Amblyopia

https://public.jaeb.org/pedig/stdy/506

Amblyopia is one of the most common causes of vision loss in the United States and elsewhere.  Current treatment with patching or eye drops is often poorly tolerated by children and therefore not done. The goal of this study is to compare the efficacy of 1 hour/day of binocular game play 5 days per week plus spectacle correction with spectacle correction only, for treatment of amblyopia in children 4 to <13 years of age.

Luminopia Study

Amblyopia is one of the most common causes of vision loss in the United States and elsewhere.  Current treatment with patching or eye drops is often poorly tolerated by children and, as a result, many patients are unable to be compliant with this treatment.  In recent years, a new type of treatment for amblyopia called dichoptic training has been tried. Dichoptic training involves giving visual information to both the lazy eye and non-lazy eye simultaneously, but in different ways to try to get the lazy eye to work better.  If effective, this may be used as an alternative to traditional therapy, such as patching. The current study is for children ages 4-7 with one lazy eye with vision between 20/40 and 20/200.  The amblyopia may be due to strabismus (eyes not staying straight) or anisometropia (eyes focusing differently), which are the 2 most common causes of amblyopia.


Studies in follow up

ROP1: Phase 1 Trial of Bevacizumab Treatment for Severe Retinopathy of Prematurity

https://public.jaeb.org/pedig/stdy/335

The primary objective of the study is to determine a dose of a single intravitreal bevacizumab injection that is effective and is lower than currently used for treatment of severe (type 1) ROP.

PON1: pediatric optic neuritis (PON) prospective outcomes study

https://public.jaeb.org/pedig/stdy/339

  1. To determine our investigators' ability to enroll children with PON into a research protocol.

  2. To develop estimates of visual acuity outcomes in children with PON 6 months following enrollment.

IXT5 – A Randomized Trial of Overminus Spectacle Therapy for Intermittent Exotropia

This is a randomized trial to determine both 1.) the long-term on-treatment effect of overminus treatment on distance IXT control scores and 2.) the off-treatment effect of overminus treatment on distance IXT control scores (following weaning and 3 months off-treatment).

IXT1 Ext –Extended Follow-Up of Subjects in the IXT1 RCT of BLR vs RRIXT1Ext - Extended

This is a follow Up of a Randomized Trial of Bilateral Lateral Rectus Recession versus Unilateral Lateral Rectus Recession with Medial Rectus Resection for Intermittent Exotropia


Upcoming studies

ATS19: Amblyopia Treatment Study 19 - Excimer Laser Surgery for Anisometropic Amblyopia

https://public.jaeb.org/pedig/stdy/507

The goal of this study is to compare the efficacy and safety of laser surgical treatment (PRK) versus non-surgical treatment of anisometropic amblyopia in children who have failed conventional treatment due to non-compliance or non-response.

IXT6 – Pilot Study RCT for Base-in Prism Spectacles for IXT

The goal of this study is to compare spectacles with relieving prism versus spectacles without relieving prism to determine whether to proceed to a full-scale, long-term randomized trial based on the following to manage intermittent exotropia.


Previous national clinical trials in which we have participated

Infant Aphakia Treatment Study

The primary purpose was to determine whether infants with a unilateral congenital cataract are more likely to develop better vision following cataract extraction surgery if they underwent primary implantation of an intraocular lens or if they were treated primarily with a contact lens. For more information: http://web1.sph.emory.edu/IATS/

Early Treatment for Retinopathy of Prematurity Study

The goal of the Early Treatment for Retinopathy of Prematurity Study (ETROP) was to test the hypothesis that earlier treatment in carefully selected cases will result in an overall better visual outcome than treatment at the conventional CRYO-ROP threshold point in the disease.

Trials we have participated in through PEDIG (Pediatric Eye Disease Investigator Group)

All of theses studies can be accessed via this link:https://public.jaeb.org/pedig/stdy/?Sort=ProtocolStatus&SortDirection=Desc

CEOS

CEOS - Congenital Esotropia Observation Study

ATS1

ATS01 - Occlusion versus Pharmacologic Therapy for Moderate Amblyopia

ATS2C

ATS02C - An Observational Study on Recurrence of Amblyopia After Discontinuation of Treatment

ATS05

ATS05 - A Randomized Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children 3 to <7 Years Old

ETS01

ETS1 - An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia

NLD01

NLD1 - A Prospective Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old

NLD02

NLD2 - A Prospective Study of Surgical Procedures for the Treatment of Persistent Nasolacrimal Duct Obstruction in Children Less Than Four Years Old

ATS09

ATS09 - A Randomized Trial Comparing Patching to Atropine for Amblyopia in Children 7 to < 13 Years Old

ATS15

ATS15 - Increasing Patching for Amblyopia Study

IXT2

IXT2 - A Randomized Clinical Trial of Observation versus Occlusion Therapy for Intermittent Exotropia

ATS17

ATS17 - A Randomized Trial of Levodopa as Treatment for Residual Amblyopia

HTS1

HTS1 - Glasses versus Observation for Moderate Hyperopia in Young Children

C02

C02 - Pediatric Cataract Surgery Outcomes Registry

ATS18

ATS18 - Study of Binocular Computer Activities for Treatment of Amblyopia

IXT3

IXT3 - A Pilot Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia