Updates

Collaborate with us Basic science

We can help basic scientists preprocess, align, and quantify their sequencing data, perform differential expression analysis, and assemble transcriptomes de novo to unlock the full potential of their genomic and transcriptomic data.

A recent basic science case study

We recently collaborated with a team of basic science researchers to characterize a novel pathogenic mutation (G118E) in the MECP2 gene, which was identified in a boy with motor dysfunction and developmental delays. After establishing human neuron and mouse models to study the mutation’s effects, the team learned that the G118E mutation leads to reduced MeCP2 protein function, which is associated with Rett syndrome. Our data science team performed the CUT&RUN analysis to explore the chromatin-binding patterns of MeCP2 in affected cells. These findings shed light on the molecular mechanisms underlying Rett syndrome and identified potential therapeutic targets. The study, titled “A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels,” was published in Genes & Development in 2023.

Get in touch with us

Texas Children's Hospital researchers can submit a ticket here.

Baylor College of Medicine researchers can submit a ticket here.

Researchers from other institutions can contact us at researchdata@texaschildrens.org