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At Texas Children’s Cancer Center, retinoblastoma research is currently focused on ocular gene therapy. The Ocular Gene Therapy Group is investigating various gene transfer approaches to treat and prevent eye diseases. It has also developed a novel approach to treating retinoblastoma with the ultimate goal not only of curing the disease, but also saving vision. We are also studying the mechanisms that spread of the disease beyond the eye in children with retinoblastoma with the goal of developing treatments for this debilitating complication of the disease.