Lisa Bouchier-Hayes, PhD
- Cancer and Blood Disorders
Associate Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
Office location:
1102 Bates Avenue
Houston, TX 77030
Get to know Lisa Bouchier-Hayes, PhD
The primary interest of Dr. Lisa Bouchier-Hayes' laboratory is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Dr. Bouchier-Hayes' research program is focused on two major areas:
- Caspase regulation in cancer
- Caspase activation during inflammation
The rationale for these investigations is that caspases protect from cancer and other diseases, by engaging diverse cellular mechanisms in addition to cell death, such as cell division, inflammation, and DNA repair.
LEARN MORE ABOUT HER LABORATORY ON BCM.EDU
Education
| School | Education | Degree | Year |
|---|---|---|---|
| Trinity College, Dublin, Ireland | Bachelors | Bachelor of Art, Genetics | 1998 |
| Trinity College, Dublin, Ireland | PhD | Doctor of Philosophy | 2002 |
| LaJolla Institute of Allergy and Immunology | Post-doctoral Fellowship | Molecular mechanisms of apoptosis | 2006 |
| St. Jude Children's Research Hospital | Post-doctoral Fellowship | Molecular mechanisms of apoptosis | 2011 |
Organizations
| Organization Name | Role |
|---|---|
| American Society of Hematology (ASH) | Member |
Honors and awards
- 2022
-
Women of Excellence Award, Baylor College of Medicine
- 2021
-
Health Professions Education Certificate, Texas Children’s Hospital Faculty College
- 2019
-
Young Investigator Award, Department of Pediatrics, Baylor College of Medicine
- 2019
-
Norton Rose Fulbright Faculty Excellence Award for Teaching and Evaluation, Baylor College of Medicine
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research Area:
Cancer Survivorship
Research interests
Cancer Survivorship
Boice, A., Lopez, K.E. Pandita, R.K., Parsons, M.J., Charendoff, C.I., Charaka, V.K., Carisey, A.F., Pandita, T.K., and Bouchier-Hayes, L. Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis. Oncogene (2022) 41:204-219.
Bolívar, B.E., Brown-Suedel, A.N., Rohrman, B.A., Charendoff, C.I., Yazdani, V., Belcher, J., Vercelotti, G., Flanagan, J.M. and Bouchier-Hayes, L. Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death. J.Immunology (2021) 206: 1878–1889.
Ando, K., Parsons, M.J., Shah, R.B., Charendoff, C.I., Paris, S.L., Liu, P.H., Fassio, S.R., Rohrman, B.A., Thompson, R., Oberst, A., Sidi, S. and Bouchier-Hayes, L. NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. Journal of Cell Biology (2017) 216:1795-1810.
Sanders, M.G., Parsons, M.J., Howard, A.G.A., Liu, J., Fassio, S.R., Martinez, J.A. and Bouchier-Hayes, L. Single cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell Death and Disease (2015) 6:e1813.
Ando, M., Hoyos, V., Yagyu, S., Tao, W., Ramos, C., Dotti, G. Brenner, M.K., and Bouchier-Hayes, L. Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Therapy (2014) 21:472-482.
Parsons, M.J., McCormick, L., Janke, L. Howard, A., Bouchier-Hayes, L.* and Green, D.R.* Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death and Differentiation (2013) 20:1174-1182.
*equal contribution as senior corresponding author