Daniel H. Leung, MD, FAASLD, FAAP
Director, Pediatric Hepatology and Liver Transplant Medicine
Director of the Viral Hepatitis Program
Professor of Pediatrics, Baylor College of Medicine
Languages: Cantonese, English
Get to know Daniel H. Leung, MD, FAASLD, FAAP
Personal Statement
Dr. Daniel H. Leung is a Professor of Pediatrics within the Division of Gastroenterology, Hepatology, and Nutrition at Baylor College of Medicine where he serves as Director of Pediatric Hepatology and Liver Transplant Medicine and the Director of the Viral Hepatitis Program at Texas Children's Hospital. He is a clinician-scientist with broad expertise in the field of pediatric hepatology who has devoted his career to the study and care of children with chronic fibroinflammatory and cholestatic liver diseases and as Director of Clinical Research within the Division of Gastroenterology, Hepatology and Nutrition from 2016-2019. He has unique expertise in the areas of liver fibrosis, biomarker indices within pediatric liver disease, and pediatric portal hypertension (See interview at https://aasldpubs.onlinelibrary.wiley.com/hub/journal/20462484/video/9-5-interview-leung and has helped spearhead a translational NIH-funded collaboration in the area of fibrosis biomarkers (5U01 DK103149-04S, Clinical Center for ChiLDREN: Pathogenesis, Biomarkers, and Antifibrotic Therapy) which he oversees within the parent ChiLDReN FORCE study (FibroScan™ in Pediatric Cholestatic Liver Disease). Dr. Leung is also devoted to the cure and treatment of children affected by hepatitis B and C and cystic fibrosis-related (CF) gastrointestinal and liver disease. He served as Lead Co-Principal Investigator for a multi-center observational longitudinal study of infants diagnosed with CF by newborn screening (BONUS) funded by the Cystic Fibrosis Foundation and has been the center Principal Investigator for the NIH funded Cystic Fibrosis Liver Disease (CLFD) Network: Prediction by Ultrasound of the risk of Hepatic Cirrhosis in CF (PUSH) study since 2010. Dr. Leung is board certified by the American Board of Pediatric Gastroenterology, Hepatology, and Nutrition and a Fellow of the American Association of the Study of Liver Diseases.
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Highlights
Sakhuja S, Staples HM, Minard CG, Ramm LE, Lewindon PJ, Ramm GA, Leung DH. Risk factors for more rapid progression of severe liver fibrosis in children with cystic fibrosis-related liver disease: A multi-center study validated by liver biopsy. Liver Int. 2023 Apr 10;. doi: 10.1111/liv.15572. [Epub ahead of print] PubMed PMID: 37035868.
Siegel MJ, Leung DH, Molleston JP, Ye W, Paranjape SM, Freeman AJ, Palermo JJ, Stoll J, Masand P, Karmazyn B, Harned R, Ling SC, Navarro OM, Karnsakul W, Alazraki A, Schwarzenberg SJ, Towbin AJ, Alonso EM, Nicholas JL, Green N, Otto RK, Magee JC, Narkewicz MR. Heterogeneous liver on research ultrasound identifies children with cystic fibrosis at high risk of advanced liver disease. J Cyst Fibros. 2023 Apr 7;. doi: 10.1016/j.jcf.2023.03.019. [Epub ahead of print] PubMed PMID: 37032248.
Leung DH, Ye W, Schwarzenberg SJ, Freeman AJ, Palermo JJ, Weymann A, Alonso EM, Karnsakul WW, Murray KF, Stoll JM, Huang S, Karmazyn B, Masand P, Magee JC, Alazraki AL, Towbin AJ, Nicholas JL, Green N, Otto RK, Siegel MJ, Ling SC, Navarro OM, Harned RK, Narkewicz MR, Molleston JP. Long-term follow-up and liver outcomes in children with cystic fibrosis and nodular liver on ultrasound in a multi-center study. J Cyst Fibros. 2023 Mar;22(2):248-255. doi: 10.1016/j.jcf.2022.07.017. Epub 2022 Aug 16. PubMed PMID: 35985930.
Banc-Husu AM, Moulton EA, Shiau H, Gutierrez Sanchez LH, Desai MS, Cerminara D, Munoz FM, Buffaloe LM, Valencia-Deray KG, Galvan NTN, Bhatnagar J, Estetter L, Rassaei N, Reagan-Steiner S, Wicker J, Dunn JJ, Allen CE, Patel KR, Harpavat S, Goss JA, Leung DH. Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis. Am J Transplant. 2023 Jan;23(1):93-100. doi: 10.1016/j.ajt.2022.10.002. Epub 2023 Jan 11. PubMed PMID: 36695626.
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS, Rosenthal P, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J, Rosenthal P, Bull L, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C, Kohli R, Wang L, Soufi N, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Hepatology. 2023 Feb 1;77(2):530-545. doi: 10.1002/hep.32777. Epub 2022 Nov 3. PubMed PMID: 36069569; PubMed Central PMCID: PMC10151059.
Shneider B, de Ville de Goyet J, Leung D, Srivastava A, Ling S, Duche M, McKiernan P, Superina R, Squires R, Sarin S, de Franchis R, Mazariegos G. Primary prophylaxis of variceal bleeding in children and the role of the mesorex bypass ¬ Summary of the Baveno VI pediatric satellite symposium. Hepatology 2016. Apr;63(4):1368-80. PMID: 26358549.
Leung, DH, Minard, C, Guffey, D, Ramm, LE, Lewindon, P, Clouston, A, Shepherd R, Ramm, GA. Aspartate Aminotransferase to Platelet Ratio and Fibrosis-4 as Biomarkers in Biopsy Validated Pediatric Cystic Fibrosis Liver Disease. Hepatology 2015 Nov;62(5):1576-83. PMID: 26223427 (BCM).
Leung, DH, Ye, Wen, Molleston, JP, Weymann, A, Ling, S, Paranjape, S, Romero, R, Schwarzenberg, S, Palermo, E, Muray, K, Marshall, B, Doo, E, Seigel, M, Krishnamurthy, R, Harned, R, Karmazyn, B, Magee, J, Narkewicz, M. Baseline ultrasound and clinical correlates in children with Cystic Fibrosis (CF). Journal of Pediatrics 2015 Oct;167(4):862-868. PMID 26254836.
Xue, M, Glenn, JS, and Leung, DH. Invited Review: Hepatitis D (HDV) in children. Journal of Pediatric Gastroenterology & Nutrition 2015 May 20. PMID 25988557.
Leung, DH, Ton-That, M, Economides, E, Healy, CM. High prevalence of Hepatitis B non-immunity in vaccinated pediatric liver transplant recipients. American Journal of Transplantation 2015 Feb;15(2):535-40. PMID 25611886.
Khaderi, SA, Shepherd, RW, Goss, JA, Leung, DH. Hepatitis C in the Pediatric Population: Transmission, Natural History, Treatment and Liver Transplantation. World Journal of Gastroenterology 2014. Aug 28;20(32):11281-11286. PMID 25170212.
Leung, DH, Ahamba, DC, Pillai, LN, Khan, MF, Smith, EO, Mahoney, DH. Unrecognized hepatitis B in pre-screened children with hematologic and oncologic conditions. Pediatric Blood & Cancer 2014 May;61(5):865-8. PMID 24249385.
Leung, DH, Narang, A, Hiremath, G, Goss, JA, Shepherd, RW. A 10-year UNOS review of mortality and risk factors in young children awaiting liver transplantation. Liver Transplantation 2016 Nov;22(11):1584-1592. PMID: 27541809.
Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children and Adolescents. Journal of Pediatric Gastroenterology & Nutrition 2012 Jun;54(6):838-55. PMID 22487950.