Daniel H. Leung, MD
- Texas Medical Center
Director, Clinical Research, Gastroenterology, Hepatology & Nutrition
Texas Children's Hospital
Acting Director, Pediatric Hepatology and Liver Transplant Medicine
Associate Professor of Pediatrics, Baylor College of Medicine
|Children's Hospital of Philadelphia||fellowship||Pediatric Gastroenterology||2009|
|Baylor College of Medicine||residency||Pediatrics||2006|
|University of Texas School of Medicine at San Antonio||medical school||Doctor of Medicine||2003|
Dr. Leung is the Acting Director of Pediatric Hepatology and Liver Transplant Medicine, and the director of the Viral Hepatitis Program at Texas Children's Hospital and also serves as Director of Clinical Research within Gastroenterology, Hepatology, and Nutrition. His research interests are focused on the epidemiology and treatment of children affected by hepatitis B and C. The Viral Hepatitis Program is developing the most current and evidence-based diagnostic and treatment protocols for children with hepatitis B and C while also providing necessary counseling to patients and their families. It also serves as the site of several state-of-the-art treatment studies for hepatitis B and C in children. In the spring/summer of 2017, we will be launching 2 new clinical trials for patients with immune clearant and immune tolerant hepatitis B and 2 new all-oral direct acting antiviral studies for patients with hepatitis C.
He also has a particular interest in gastrointestinal and liver diseases associated with cystic fibrosis (CF). He served as Lead Co-Principal Investigator for a multi-center observational longitudinal study of infants diagnosed with CF by newborn screening (BONUS) funded by the Cystic Fibrosis Foundation and currently is the center Principal Investigator for the NIH funded Cystic Fibrosis Liver Disease (CLFD) Network: Prediction by Ultrasound of the risk of Hepatic Cirrhosis in CF (PUSH) study and co-investigator on an RO1 grant focused on the intestinal microbiome of CF infants. He remains active as a local co-investigator of the ChiLDReN (The Childhood Liver Disease Research and Education Network) with diverse expertise and interests in non-invasive markers of fibrosis and portal hypertension (See interview at http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/9-5-interview-leung.html).
Dr. Leung is board certified by the American Board of Pediatrics, and the American Board of Pediatric Gastroenterology, Hepatology, and Nutrition.
|American Association for the Study of Liver Diseases||Member, Pediatric SIG Steering Committee 2013-2016|
|American Liver Foundation||Board of Directors, President|
|North American Society for Pediatric Gastroenterology, Hepatology and Nutrition||Member, Hepatology Committee 2010-2013|
Leung, DH, W Klish et al. Age and ethnic-specific elevation of ALT among obese children at risk for NASH: Implications for Screening. Clinical Pediatrics 2009, Jan; 48(1):50-7 PMID 18832535.
Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children and Adolescents. Journal of Pediatric Gastroenterology & Nutrition 2012 Jun;54(6):838-55. PMID 22487950.
Leung, DH, Ahamba, DC, Pillai, LN, Khan, MF, Smith, EO, Mahoney, DH. Unrecognized hepatitis B in pre-screened children with hematologic and oncologic conditions. Pediatric Blood & Cancer 2014 May;61(5):865-8. PMID 24249385.
Khaderi, SA, Shepherd, RW, Goss, JA, Leung, DH. Hepatitis C in the Pediatric Population: Transmission, Natural History, Treatment and Liver Transplantation. World Journal of Gastroenterology 2014. Aug 28;20(32):11281-11286. PMID 25170212.
Leung, DH, Ton-That, M, Economides, E, Healy, CM. High prevalence of Hepatitis B non-immunity in vaccinated pediatric liver transplant recipients. American Journal of Transplantation 2015 Feb;15(2):535-40. PMID 25611886.
Xue, M, Glenn, JS, and Leung, DH. Invited Review: Hepatitis D (HDV) in children. Journal of Pediatric Gastroenterology & Nutrition 2015 May 20. PMID 25988557.
Leung, DH, Ye, Wen, Molleston, JP, Weymann, A, Ling, S, Paranjape, S, Romero, R, Schwarzenberg, S, Palermo, E, Muray, K, Marshall, B, Doo, E, Seigel, M, Krishnamurthy, R, Harned, R, Karmazyn, B, Magee, J, Narkewicz, M. Baseline ultrasound and clinical correlates in children with Cystic Fibrosis (CF). Journal of Pediatrics 2015 Oct;167(4):862-868. PMID 26254836.
Leung, DH, Minard, C, Guffey, D, Ramm, LE, Lewindon, P, Clouston, A, Shepherd R, Ramm, GA. Aspartate Aminotransferase to Platelet Ratio and Fibrosis-4 as Biomarkers in Biopsy Validated Pediatric Cystic Fibrosis Liver Disease. Hepatology 2015 Nov;62(5):1576-83. PMID: 26223427 (BCM).
Shneider B, de Ville de Goyet J, Leung D, Srivastava A, Ling S, Duche M, McKiernan P, Superina R, Squires R, Sarin S, de Franchis R, Mazariegos G. Primary prophylaxis of variceal bleeding in children and the role of the mesorex bypass ¬ Summary of the Baveno VI pediatric satellite symposium. Hepatology 2016. Apr;63(4):1368-80. PMID: 26358549.
Leung, DH, Narang, A, Hiremath, G, Goss, JA, Shepherd, RW. A 10-year UNOS review of mortality and risk factors in young children awaiting liver transplantation. Liver Transplantation 2016 Nov;22(11):1584-1592. PMID: 27541809.
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