Texas Medical Center
1102 Bates Ave., Ste. 1025.09
Houston, TX 77030
Andrew Yee, PhD
The balance between bleeding and clotting must be carefully maintained to ensure proper blood function. The blood clotting protein, von Willebrand factor (VWF), critically contributes to this balance. Functional deficits in VWF can lead to extensive blood loss while overactivity can lead to undesired blood clots that block major blood vessels. The molecular determinants of VWF activity are highly variable.
Our current research aims to determine the functional consequences of all variations in VWF using novel methodologies that may be applied to other blood clotting factors. The goals of this research are to more accurately predict outcomes in patients with bleeding or clotting disorders and to develop novel therapeutics to prevent hemorrhagic or thrombotic complications.
2020, Scholar Award, American Society of Hematology
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