Duncan NRI Hyun Kyoung Lee, Ph.D.
Associate Professor, Department of Pediatrics and Department of Neurology, Baylor College of Medicine
Principal Investigator, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital
Cynthia and Anthony G. Petrello Endowed Scholar in Neurological Research, Texas Children's Hospital
Member, Center for Cancer Neuroscience
Member, Dan L Duncan Comprehensive Cancer Center, Center for Drug Discovery
Contact Information
Phone: 832-824-8955
Fax: 832-825-1249
Email: hyunkyol@bcm.edu
Research focus
The Lee lab studies developmental gliogenesis and associated disorders; white matter injuries (PVL, HIE, MS), brain cancer (GBM), and ischemic stroke.
Get to know Hyun Kyoung Lee, Ph.D.
In my laboratory, we plan to take an interdisciplinary approach to the study of neural development and eventually, neurodegenerative diseases. Glia play diverse roles in the functioning CNS and, consequently, are associated with numerous neurological disorders and malignancies. In spite of their vital role in CNS physiology and pathology, the molecular mechanisms that control their development and diversity remain poorly defined; accordingly, how these processes contribute to CNS pathology also remains undefined. Therefore, our studies focus on the identification of novel molecular signaling and regulatory pathway in glial cell development using chick and mouse model systems and biochemical techniques combined with an array of complex CNS injury in vivo models. These studies will provide the foundation upon which we will translate developmentally relevant findings to demyelinating diseases, neurodegenerative disorders, and vascular-associated diseases in an effort to develop therapeutic interventions.
Ye Qi, Jo J, Wang CY, Oh H, Choy TJ, Kim KI, D’Alessandro A, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, and Lee HK. Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Rep. 2024 May 5;43(5):114193.
Wang CY, Zho Z, Jo J, Kim KI, Madamba C, Ye Q, Jung SY, Bellen HJ, Lee HK. Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury. PNAS 2023 Aug 29;120(35):e2304112120.
Chung HL*, Ye Q*, Park YJ, Zuo Z, Mok JW, Kanca O, Tattikota SG, Lu S, Perrimon N, Lee HK#, Bellen HJ#. Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell Metab. 2023 May 2;35(5):855-874.e5. (*Co-corresponding authors)
Cristobal CD and Lee HK. Development of myelinating glia: an overview. Glia 2022 Dec;70(12):2237-2259.
Cristobal CD*, Wang CY*, Zuo Z, Smith J, Bellen H, Lee HK. Daam2 regulates myelin structure and the oligodendrocyte actin cytoskeleton through Rac1 and Gelsolin. J. Neurosci. 2022 Mar 2;42(9):1679-1691.
Jo J, Woo JS, Cristobal CD, Wang C, Ye Q, Smith JA, Ung K, Liu G, Arenkiel BR, Lee HK. Daam2 modulates astrocyte morphology leads to neuronal activity and behaviors in normal and stroke condition. EMBO Rep. 2021 Oct 11;e53200. “Featured Cover image”
Ding X, Jo J, Cristobal CD, Zuo Z, Wang CY, Wirianto M, Ye Q, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen H, Yoo, SH, Lee HK. The Daam2-VHL-Nedd4 Axis Governs Developmental and Regenerative Oligodendrocyte Differentiation. Genes Dev. 2020 Sep 1;34(17):1177-1189. (“Featured Cover image” and “Featured in Image of the Month from the Labs from BCM”)
View a complete list of publications by Hyun Kyoung Lee, Ph.D.
