Amazing research breakthroughs mean that hope is on the horizon

Researchers at the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s Hospital are at the forefront of research on Rett syndrome and other neurogenetic disorders. Our teams are working to develop promising new diagnostic tools and treatments by finding potential drug targets, evaluating deep brain stimulation as a treatment for Rett syndrome and exploring ways to reduce or even reverse its symptoms.

Read more about our recent research projects and findings for Rett syndrome and related disorders.

Deep brain stimulation induces more healthy neurons and sustained memory benefits in Rett animals.

Reduced inhibition of hippocampal neurons impairs long-term memory recall in Rett syndrome.

Researchers identify DNA elements that affect MECP2 expression.

A preclinical study validates antisense oligonucleotides as a feasible approach to treat MECP2 duplication disorder.

New study reveals potential drug targets for MECP2 duplication and Rett syndromes.

Deep brain stimulation can correct neural malfunction in Rett and MeCP2 duplication syndrome mice.

NRI researchers develop a rat model of Rett syndrome.

Reducing MeCP2 levels reverses MeCP2 duplication syndrome.