Tor Savidge, PhD
Principal Investigator, Neuroimmune-Microbe Interactions
Associate Director, Texas Children’s Microbiome Center
Professor, Pathology & Immunology and Pediatrics, Baylor College of Medicine
Languages: English
Departments:
Get to know Tor Savidge, PhD
Personal Statement
Dr. Savidge is interested in studying neuroimmune-microbial interactions in the gastrointestinal tract using a range of techniques that include computational and structural biology, global metabolomics and proteomics, realtime molecular interactions, cell culture and humanized disease models. These studies have found that gut astrocytes are important regulators of mucosal barrier function and inflammation in inflammatory bowel disease, necrotizing enterocolitis and Clostridium difficile infection. A novel innate host defense mechanism for subverting microbial pathogenesis has also been identified and is being translated into a prototypic form of therapy termed allosteric therapeutics.
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One. 2013;8(3):e58634.
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http://www.ncbi.nlm.nih.gov/pubmed?term=Savidge%2C%20Tor%5BAuthor%5D