Shubham Singh, PhD

Education

Honors and awards

2022

Human Frontier Science Postdoctoral Fellowship

2021

Bluefield Postdoctoral Fellowship

2021

Sun Pharma Science Scholar Award

2021

DST-AWSAR Award

2012

DBT Biology Scholarship Award

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research Area:
Genetics and Genomics

Our research focuses on lipid metabolism and signaling in mammalian physiology. Lipids are fundamental to cellular compartmentalization, signaling, energy production and metabolism. As life evolved, lipid diversity increased requiring cells to develop precise metabolic and transport mechanisms. Dysregulation of lipid homeostasis is linked to over 100 human diseases including obesity, lipodystrophy, neurodegeneration, and cancer. However, the fundamental mechanisms of lipid homeostasis and how its disruption leads to diseases remain poorly understood. We are particularly interested in understanding mechanisms of lipid homeostasis in context of development and maintenance of central nervous system (where lipids contribute ~50% of the dry mass). We aim to identify and elucidate mechanisms through which aberrant lipid metabolism/signaling contribute to pathophysiology of neurodegeneration and brain tumors

Research interests

• Lipid Metabolism
• Chemical Biology
• Neurobiology
• Cell Biology
• Genetics

Ambaw, Y., Ljubenkov, P. A., Singh, S., Hamed, A., Sebastian, B., Boxer, A. L., Walther*, T.C., Farese*, R.V. (2025). Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations. Biorxiv.

Hamed, A., Ambaw, Y., Singh, S., Weng, Z. L., Farese*, R.V., Walther*, T.C (2025). LipidCruncher: an open-source web application for processing, visualizing, analyzing lipidomics data. Biorxiv. App: http://lipidcruncher-alb-2004716200.us-east-1.elb.amazonaws.com:8501/

Singh, S., U. D., Ambaw, Y., Joshua L.S., Farese*, R.V., Walther*, T.C (2024). PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Cell 187(24), 6820-6834.e24.

Sebastian^#, B., Swarup^#, S., Ambaw, Y, Richards, R.C., Fischer, A.W., Singh, S., Aggarwal, G,….,Harper, J.W., Walther*, T.C., Farese*, R.V. (2023) Deficiency of frontotemporal dementia gene GRN results gangliosidosis. Nature Communications 13, 5924.

5. Mondal, S., Kinatukara, P., Singh, S., Sailasree, P., Patil G. S., Shambhavi, S., Madduri, K. M., Kamat, S. S., Kumar, S., Sankaranarayanan*, R. (2022) A conserved FAAL domain-containing Disco-interacting protein 2 mediates DAG homeostasis in eukaryotes, eLife 11, e77665.