H. Daniel Lacorazza, PhD
Principal Investigator, Experimental Immunology & Hematology
Member, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
Associate Professor, Department of Pathology & Immunology and Pediatrics, Baylor College of Medicine
Languages: English
Departments:
Get to know H. Daniel Lacorazza, PhD
Education
| School | Education | Degree | Year |
|---|---|---|---|
| Memorial Sloan-Kettering Cancer Center | Fellowship | 1999 | |
| National Institutes of Health | Fellowship | 1995 | |
| University of Buenos Aires | PhD | Doctor of Philosophy | 1992 |
Organizations
| Organization Name | Role |
|---|---|
| Stem Cell and Regenerative Medicine (STaR) Center | Associate Member |
| American Society of Hematology | Member |
| Society for Leukocyte Biology | Member |
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
The major goal of Lacorazza’s lab is to better understand the molecular control of normal and malignant hematopoiesis. Lacorazza’s lab studies genes that control the balance between quiescence, a non-proliferative state poised to re-enter the cell cycle, self-renewal, and differentiating proliferation in hematopoietic stem cells. His group then investigates how these genes are deregulated during leukemogenesis and the effect on the survival and self-renewal of leukemic stem cells aimed at the development of targeted therapy for pediatric and adult leukemias.
Suppipat K, Park CS, Shen Y, Zhu X, Lacorazza HD. Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. PloS One 2012; 7(12):e51251.
Shen, Y, Park, CS., Suppipat, K., Mistretta, T.A., Puppi, M., Horton, T., Rabin, K., Gray, N.S., Meijerink, J.P.P., and Lacorazza, H.D. Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway. Leukemia (2017) 31(6):1314-1324.