Skip to main content

Virtual visit appointments available 7 days a week from 9:00am to 11:00pm. Learn More

COVID-19 Updates

COVID-19 Updates: Get the latest on vaccine information, in-person appointments, virtual visits and more. Learn More

Notice: Street Closure

Street Closure: Texas Medical Center Campus road closures, September 29 - October 1, that will impact patients and visitors. Learn More | En Español


Texas Medical Center

Cancer and Hematology
Phone: 832-822-4840
Fax: 832-825-4732


1102 Bates Ave., Ste. 1570
Houston, TX 77030

Meenakshi G. Hegde, MD

Associate Professor, Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine


School Education Degree Year
Baylor College of Medicine Fellowship Pediatric Hematology/Oncology 2012
University of Illinois at Chicago, Corner Children's Hospital Residency Pediatrics 2009
Bangalore Medical College, India Internship/Residency Pediatrics 2005
J.S.S. Medical College, Mysore, India Medical School Doctor of Medicine 2003


Dr. Meenakshi Hegde is a pediatric oncologist engaged in translational research on immunotherapy to improve patient outcomes in high-risk cancer. Her research was the first to demonstrate that a highly heterogeneous landscape of antigen expression in glioblastoma and other solid tumors benefitted from simultaneous targeting of these antigens using a novel bispecific CAR T-cell (TanCAR).

Her current efforts focus on the tumor complex rather than the tumor cell to develop effective T-cell based platform resistant to the inhibitory pathways within the tumor environment and  translation of newly developed cellular therapies from the laboratory to clinic through well-designed clinical trials to shape standard of care practices in the field of high-risk cancer therapy. Her clinical interests span adoptive cellular therapy and bone marrow transplant.

Dr. Hegde is a member of the Brain Tumor Research Program at Texas Children's Cancer Center, the Center for Cell and Gene Therapy, and the Bone Marrow / Stem Cell Transplant Program.

She is a board certified physician-specialist in pediatric hematology/oncology and a member of the American Board of Pediatrics.

Board Certifications
American Board of Pediatrics
American Board of Pediatrics - Pediatric Hematology/Oncology


Organization Name Role
American Academy of Pediatrics (AAP)
American Association for Cancer Research (AACR)
American Society of Bone Marrow Transplant (ASBMT) Member
American Society of Clinical Oncology (ASCO) Member
Children's Oncology Group (COG) Member
Karnataka Medical Council, India Member
Society for Immunotherapy of Cancer (SITC) Member

Research Statement

Solid tumors enable immune evasion by expressing high-levels of immune-inhibitory ligands that attenuate anti-tumor responses by inducing functional exhaustion and apoptotic death of the activated tumor-antigen specific T cells. Programmed death ligand-1 (PD-L1; B7-H1)/ programmed death protein-1 (PD-1; CD279) immune-checkpoint is a key mediator of this tumor-derived immune-inhibition.

Using a glioma model, she is currently investigating how PD-L1/PD-1 axis can be best manipulated to enhance the anti-tumor efficacy of adoptively transferred chimeric antigen receptor (CAR) T cells.

This approach will create a broad T-cell engineering platform to modulate tumor derived immune-inhibitory signals for improved cellular therapy of solid tumors.

Learn about the Center for Cell and Gene Therapy on

Awards & Honors

2020 Young Investigator Award, Department of Pediatrics, Baylor College of Medicine
  Team Science Award, American Association for Cancer Research (AACR)
  Schwiesguth Prize, International Society of Paediatric Oncology (SIOP)
2014 Young Investigator Award, American Society of Pediatric Hematology-Oncology (ASPHO)
2012 Hyundai Hope on Wheels Scholar




* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.