Lindsay C. Burrage, MD, PhD
- Genetics
Associate Professor, Department of Molecular and Human Genetics, Baylor College of Medicine
Phone:
832-822-4280
Languages: English
Departments:
Get to know Lindsay C. Burrage, MD, PhD
Personal Statement
As a pediatrician and clinical geneticist, my primary clinical interest is in the diagnosis and management of a wide range of genetic disorders. I have a particular interest in the diagnosis and management of inborn errors of metabolism and skeletal dysplasias.
From Dr. Burrage
I strive to provide evidence-based care to all of my patients. In addition, I enjoy partnering with each of the families in my clinic in order to personalize the care that we provide to each patient and family.
When I am not working, I enjoy spending time with my family. My interests include reading, knitting and ballet.
Clinical Interests and Specialization
Inborn errors of metabolism
Skeletal dysplasias
Pediatric genetics
Undiagnosed genetic disorders
Research interests
As a physician-scientist and clinical biochemical geneticist, I have a long-standing interest in the pathophysiology of inborn errors of metabolism and their utility as models for more common disorders. Our group uses laboratory-based approaches in murine models and clinical studies to gain a greater understanding of the etiology of long-term complications of inborn errors of metabolism with a special focus on urea cycle disorders in order to optimize management strategies for our patients. In addition, I am involved in a variety of projects, such as the Undiagnosed Diseases Network, focusing on the discovery of novel genes associated with rare genetic disorders. I am also a co-Principal Investigator for the Baylor College of Medicine Center for Precision Medicine Models which develops preclinical models to support gene discovery and to test novel therapeutic strategies for rare disorders.
Department of Molecular and Human Genetics
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Nagamani SC, Ali S, Izem R, Schady D, Masand P, Shneider B, Leung D, Burrage LC. (2021). Biomarkers for Liver Disease in Urea Cycle Disorders. Molecular Genetics and Metabolism. 133(2):148-156.
Stroup BM, Marom R, Li X, Hsu C, Chang C, Truong LD, Dawson B, Grafe I, Chen Y, Jian M, Lanza D, Green JR, Sun Q, Barrish JP, Ani S, Christiansen AE, Seavitt JR, Dickinson ME, Kheradmand F, Heaney JD, Lee B, Burrage LC. (2020). A Global Slc7a7 Knockout Mouse Model Demonstrates Characteristic Phenotypes of Human Lysinuric Protein Intolerance. Human Molecular Genetics. Aug 3;29(13):2171-2184.
Burrage LC, Thistlethwaite, L, Stroup BM, Sun, Q, Miller, MJ, Nagamani, SCS, Craigen W, Scaglia, F, Sutton VR, Graham B, Kennedy AD, Members of the UCDC, Milosavljevic A, Lee BH, Elsea SH. (2019). Untargeted Metabolomic Profiling Reveals Multiple Pathway Perturbations and New Clinical Biomarkers in Urea Cycle Disorders. Genetics in Medicine. 21:1977-1986.
Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry D, Raman V, Chitayat D, ChinnIK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng C, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, University of Washington Center for Mendelian Genomics, Undiagnosed Diseases Network, Bertola D, Yamamoto G, Baratela WAR, Butler M, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. (2019). Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. American Journal of Human Genetics. 104:422-438.
Santiago-Sim T*, Burrage LC*, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogné B, Küry S, Besnard T,Isidor B, Bézieau S, Hazart I, Nagakura H, Immken LL, Littlejohn RO, Roeder E, EuroEPINOMICS RES Consortium Autosomal Recessive working group, Caglayan SH, Kara B,1 Hardies Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg C, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel P, Heaney JD, Walkiewicz MA. (2017). Biallelic Loss-of-Function Mutations in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures, Microceophaly, Absent Speech, Hypotonia, Growth Retardation with Prenatal Onset, and Dysmorphic Features. American Journal of Human Genetics. 100(4):676-688. *Contributed equally.
Burrage LC, Sun Q, Elsea SH, Jiang M, Nagamani SCS, Frankel AE, Stone E, Alters S, Johnson DE, Rowlinson SW, Georgiou G, Members of the Urea Cycle Disorders Consortium, Lee BH. (2015). Human Recombinant Arginase Enzyme Reduces Plasma Arginine in Mouse Models of Arginase Deficiency. Human Molecular Genetics. 24:6417-27.
Burrage LC, Charng WL, Eldomery MK, Willer JR, Davis EE, Lugtenberg D, Zhu W, Leduc M, Akdemir ZC, Azamian M., Zapata G, Hernandez PP, Schoots J, de Munnik S,Roepman R, Jhangiani S, Katsanis N, Vissers LELM, Brunner HG, Beaudet AL, Rosenfeld JA, Muzny DM, Gibbs RA, Eng CM, Xia F, Lalani SR, Lupski JR, Bongers EMHF, Yang Y. (2015). De novo GMNN mutations cause autosomal dominant primordial dwarfism associated with Meier-Gorlin syndrome. American Journal of Human Genetics. 97:904-13.
