Geoffrey A. Preidis, MD, PhD
Dr. Preidis’s goal is to provide the highest quality of compassionate patient care by leveraging the latest advances in gastroenterological, liver, nutritional, and microbiome research.
Geoffrey A. Preidis, M.D., Ph.D. is a Pediatric Gastroenterologist with basic research expertise in nutrition-sensitive mechanisms that regulate physiology, growth, and development. These include liver and intestinal gene regulation, enteric nervous system biology and gastrointestinal motility, bile acid homeostasis, and interactions between diet and the gut microbiome. He is actively involved in clinical and translational investigations of neonates and children with intestinal, liver, and nutritional disorders. His biomedical research career began during his undergraduate studies at Harvard University. He developed an interest in Pediatric Gastroenterology during his years in the Medical Scientist Training Program (M.D./Ph.D.) at Baylor College of Medicine. He completed internship and residency training in Pediatrics, as well as fellowship training in Pediatric Gastroenterology, Hepatology & Nutrition, at Baylor College of Medicine.
The goal of Dr. Preidis’s laboratory is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition impairs intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. This work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and psychosocial factors, including preterm and underweight newborns in the neonatal intensive care unit, adolescents with anorexia nervosa, and children with severe acute malnutrition in the developing world.
Thaxton GE, Melby PC, Manary MJ, Preidis GA. New insights into the pathogenesis and treatment of malnutrition. Gastroenterology Clinics of North America 2018; 47:813-827. Preidis GA, Kim KH, Moore DD. Nutrient sensing nuclear receptors PPAR-alpha and FXR control liver energy balance. The Journal of Clinical Investigation 2017;127:1193-1201. Velly H, Britton RA, Preidis GA. Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host. Gut Microbes 2017;8:98-112. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Microbial-derived metabolites reflect an altered intestinal microbiota during catch-up growth in undernourished neonatal mice. The Journal of Nutrition 2016;146:940-8. Preidis GA, Keaton MA, Campeau P, Bessard BC, Conner ME, Hotez PG. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. The Journal of Nutrition 2014;144:273-81. Preidis GA, Hill C, Guerrant RL, Ramakrishna BS, Tannock GW, Versalovic J. Probiotics, enteric and diarrheal diseases, and global health. Gastroenterology 2011;140:8-14. Preidis GA, Versalovic J. Targeting the human microbiome with antibiotics, probiotics, and prebiotics: Gastroenterology enters the metagenomics era. Gastroenterology 2009;136:2015-2031.
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