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Texas Medical Center

Critical Care, Kidney (Renal), Anesthesiology
Phone: 832-826-6230
Fax: 832-825-3889


6651 Main Street
MC E1420
Houston, TX 77030

Ayse Akcan-Arikan, MD

Medical Director, Critical Care Nephrology and Acute Dialysis

Medical Director, Extracorporeal Liver Support
Associate Professor of Pediatrics, Divisions of Critical Care Medicine and Nephrology, Department of Pediatrics, Baylor College of Medicine


School Education Degree Year
Baylor College of Medicine Fellowship Pediatric Nephrology 2012
Baylor College of Medicine Residency Pediatrics 2011
Baylor College of Medicine Fellowship Pediatric Nephrology 2006
Baylor College of Medicine Fellowship Pediatric Critical Care 2004
Istanbul University-Turkey Residency Pediatrics 2001
Istanbul University-Turkey Internship Pediatrics 1997
Istanbul University-Turkey Medical School Doctor of Medicine 1996


Dr Akcan-Arikan is a dual trained pediatric intensivist and nephrologist and an Associate Professor of Pediatrics with tenure at Baylor College of Medicine. Dr Arikan is a clinician-scientist whose research focus is on the recognition and management of acute kidney injury in the critically ill, pharmacokinetics in extracorporeal therapies, management of multiple organ failure, as well as sepsis resuscitation and outcomes. She is supported by the National Institutes of Health (NIH) for her work in new noninvasive methods for real-time monitoring of organ dysfunction and pharmacokinetics in critically ill children. She is an Executive Committee member of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) supported Collaborative Pediatric Critical Care Research Network (CPCCRN) and serves as a core site principal investigator. She is also an executive committee member for the Prospective Pediatric Acute Kidney Injury Research Group (ppAKI-RG) and Worldwide Exploration of Renal Replacement Therapy Outcomes (We-ROCK) research collaboratives. She is an associate editor for renal critical care for the journal Pediatric Critical Care Medicine. She is the site principal investigator of multiple pediatric renal support device studies as well as urinary biomarkers.

Dr Arikan also serves as the Medical Director of the Critical Care Nephrology and Inpatient Dialysis and the Medical Director of the Extracorporeal Liver Support programs at Texas Children’s Hospital. The renal support program is one of the largest in the nation and averages more than 6000 acute dialytic procedures annually. The critical care nephrology program houses the inaugural postdoctoral advanced training in pediatric critical care nephrology in North America as well as a unique quality assurance and improvement program in acute renal extracorporeal therapies based on active surveillance of patient safety, both under Dr Arikan’s leadership.

Clinical Interests:

• Intensive Care Nephrology

• Acute kidney injury

• Acute liver failure / MARS (Molecular Adsorbent Recirculating System)

Research Interests:

• CRRT (continuous renal replacement therapy)

• Nutrition on acute dialysis

• Cardiorenal syndrome

• Hepatorenal syndrome


Organization Name Role
American Society of Nephrology Member
American Society of Pediatric Nephrology Member
European Society of Critical Care Medicine Member
International Society of Nephrology Member
Society of Critical Care Medicine Member
Society of Pediatric Research Member

Selected Publications

Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL, Akcan-Arikan A, et al. (AWARE Investigators). Epidemiology of acute kidney injury in critically ill children and young adults. New England Journal of Medicine 376 (1), 11-20, PubMed: PMC5322803, 2017.

Rodriguez K, Srivaths PR, Tal L, Watson MN, Riley AA, Himes RW, Desai MS, Braun MC, Akcan Arikan A. Regional citrate anticoagulation for continuous renal replacement therapy in pediatric patients with liver failure. PLoS One 12(8):e0182134. PubMed PMC5549692, 2017.

Akcan-Arikan A, Gebhard DJ, Arnold MA, Loftis LL, Kennedy CE. Fluid Overload and Kidney Injury Score: A Multidimensional Real-Time Assessment of Renal Disease Burden in the Critically Ill Patient. Pediatric Critical Care Medicine 18(6), 524-30, PubMed PMID: 28406863, 2017.

Arikan AA, Zappitelli M, Goldstein SL, Naipaul A, Jefferson LS, Loftis LL. Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatric Critical Care Medicine 13(3), 253-8, PMID: 21760565, 2012.

Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney International 71(10), 1028-35, PubMed PMID: 17396113, 2007.

View VIICTR Publications

View Google Scholar Publications

* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.