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Location

Texas Medical Center

Specialty
Cancer and Hematology
Phone: 832-824-4290
Email

ancourt1@texaschildrens.org

Address

1102 Bates Ave., 12th Floor
Houston, TX 77030

Research Laboratory

Amy N. Courtney, PhD

Assistant Professor, Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine

Education

School Education Degree Year
Baylor College of Medicine Post-doctoral Fellow Tumor Immunology 2013
University of Texas Health Science Center, Houston PhD Doctor of Philosophy, Viral Immunology 2010
Texas A&M University Bachelors Bachelor of Science 2003

About

Dr. Amy Courtney is an immunologist with over fifteen years of experience in both basic and translational research. Her research has focused primarily on invariant natural killer T (NKT) cells, specifically how to utilize their unique biological characteristics to treat various illnesses. 

She has worked in collaboration with others to develop and optimize protocols for isolating and ex vivo expanding human NKTs for clinical applications. She is currently the lead investigator performing correlative studies for two phase 1 clinical trials. The first trial is a first-in-human phase 1 clinical trial that utilizes ex vivo expanded NKTs expressing a chimeric antigen receptor in neuroblastoma patients (NCT03294954) and the interim results of this trial have recently been published (Heczey et al, Nat Med, 2020). The second trial is a phase 1 clinical trial with an allogeneic CD19.CAR NKT product for adult lymphoma patients (NCT03774654). 

She is also interested in the cross-talk between NKTs and immunosuppressive tumor-associated macrophages (TAMs), which have been shown to correlate with both metastatic disease and poor outcome in neuroblastoma patients. Her work has revealed that human NKTs mediate anti-neuroblastoma activity through both direct and indirect interactions with tumor-supportive TAMs. Currently, she is utilizing a transgenic murine model of neuroblastoma to further explore the role of NKT-TAM interactions in tumor immune surveillance. 

Organizations

Organization Name Role
Advances in Neuroblastoma Research Association (ANRA) Member
American Association of Immunologists (AAI) Member

Research Statement

Amy Courtney's main focus in the lab is to examine the impact of natural killer T cells (NKTs) on the neuroblastoma microenvironment.  In particular, she is interested in the cross-talk between NKTs and immunosuppressive tumor-associated macrophages (TAMs), which have been shown to correlate with both metastatic disease and poor outcome in neuroblastoma patients. Her work has determined that human NKTs directly target TAMs in both a contact-dependent and -independent manner. Currently, she is utilizing a transgenic murine model of neuroblastoma to further explore the role of NKT-TAM interactions in tumor immune surveillance.  

As part of our recently initiated first-in-human CAR NKT cell clinical trial in children with neuroblastoma (NCT03294954), she will perform correlative studies on patient samples to determine the effect of the adoptively transferred CAR NKTs on a variety of immune cell subsets. In addition, she is optimizing established procedures for isolation and ex vivo expansion of NKTs from human peripheral blood (Heczey et al, Blood, 2014).

Selected Publications

Awards & Honors

2016    AAI Abstract Trainee Award and oral presenter, 103rd Annual Meeting of the American Association of Immunologists (AAI)

2012    AAI Abstract Trainee Award and oral presenter, 99th Annual Meeting of the American Association of Immunologists (AAI)

2012    Keystone Future Science Fund Travel Scholarship, The Role of Inflammation during Carcinogenesis Conference, Keystone Symposia

2012    Prize for oral presentation, Texas Children’s Cancer and Hematology Center 8th Annual Research Symposium

2009    Travel Scholarship, 5th International Symposium on CD1/NKT Cells

2009    Prize for poster presentation, 1st Annual GSBS Immunology Program Retreat

2007    Smith Educational Program Fellowship

Language

English



* Texas Children's Hospital physicians' licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician's office and were not verified by Texas Children's Hospital.