Amy N. Courtney, PhD

Location

  • Texas Medical Center

Phone: 832-824-4290

Contact Information

1102 Bates Ave., 12th Floor
Houston, TX 77030
United States
Texas US

Research Laboratory

Research Area

  • Neuroblastoma

Instructor, Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine

Education

School Education Degree Year
Baylor College of Medicine post-doctoral fellow Tumor Immunology 2013
University of Texas Health Science Center, Houston PhD Doctor of Philosophy, Viral Immunology 2010
Texas A&M University bachelors Bachelor of Science 2003

Organization

Organization Name Role
Advances in Neuroblastoma Research Association (ANRA) Member
American Association of Immunologists (AAI) Member

Research Statement

Amy Courtney's main focus in the lab is to examine the impact of natural killer T cells (NKTs) on the neuroblastoma microenvironment.  In particular, she is interested in the cross-talk between NKTs and immunosuppressive tumor-associated macrophages (TAMs), which have been shown to correlate with both metastatic disease and poor outcome in neuroblastoma patients. Her work has determined that human NKTs directly target TAMs in both a contact-dependent and -independent manner. Currently, she is utilizing a transgenic murine model of neuroblastoma to further explore the role of NKT-TAM interactions in tumor immune surveillance.  

As part of our recently initiated first-in-human CAR NKT cell clinical trial in children with neuroblastoma (NCT03294954), she will perform correlative studies on patient samples to determine the effect of the adoptively transferred CAR NKTs on a variety of immune cell subsets. In addition, she is optimizing established procedures for isolation and ex vivo expansion of NKTs from human peripheral blood (Heczey et al, Blood, 2014).

Selected Publications

Awards

2016    AAI Abstract Trainee Award and oral presenter, 103rd Annual Meeting of the American Association of Immunologists (AAI)
2012    AAI Abstract Trainee Award and oral presenter, 99th Annual Meeting of the American Association of Immunologists (AAI)
2012    Keystone Future Science Fund Travel Scholarship, The Role of Inflammation during Carcinogenesis Conference, Keystone Symposia
2012    Prize for oral presentation, Texas Children’s Cancer and Hematology Centers 8th Annual Research Symposium
2009    Travel Scholarship, 5th International Symposium on CD1/NKT Cells
2009    Prize for poster presentation, 1st Annual GSBS Immunology Program Retreat
2007    Smith Educational Program Fellowship