Toxic Epidermal Necrolysis

Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction--frequently antibiotics or antivonvulsants.

What are the symptoms of toxic epidermal necrolysis?

Toxic epidermal necrolysis causes the skin to peel in sheets, leaving large, raw areas. The loss of skin allows fluids and salts to ooze from the raw, damaged areas and increases the risk of infection. The following are the most common symptoms of toxic epidermal necrolysis. However, each child may experience symptoms differently. Symptoms may include:

• A painful, red area that spreads quickly
• The skin may peel without blistering
• Raw areas of skin
• Discomfort
• Fever
• Blistering, pain or redness of the eyes, mouth or throat, genitals, urethra, and/or anus

The symptoms of toxic epidermal necrolysis may resemble other skin conditions. Always consult your child's doctor for a diagnosis.

Treatment for toxic epidermal necrolysis

The disease progresses fast, usually within three days. Treatment includes hospitalization, often in the burn unit. If a medication is causing the skin reaction, it is discontinued. Specific treatment for toxic epidermal necrolysis will be determined by your child's doctor based on:

• Your child's age, overall health, and medical history
• Extent of the disease

Treatment may include the following:

• Hospitalization
• Isolation to prevent infection
• Protective bandages
• Intravenous fluid and electrolytes
• Antibiotics
• Intravenous immunoglobulin G
• Intravenous steroids