Translational Imaging Group

The Translational Imaging Group (TIGr) is a rich mixture of engineers, clinicians, biologists, and mathematicians, ranging from early career scientists and graduate students to mature researchers with 30+ years of professional experience. We design, build, and test novel imaging methods, devices and materials that could become the medical imaging technologies of the future. Ongoing developments in our laboratories include:

  • Novel nanoparticle contrast agents for CT and MRI 
  • Next-generation molecular imaging agents 
  • Next-generation near-infrared imaging devices for optical deep-tissue imaging
  • Development of novel imaging agents and methods for low-field permanent magnet MRI

An underlying principle of TIGr is to first identify a medical need, always in collaboration with a physician, and then pursue a novel technological solution to the associated problem. Formulating our projects in this manner allows us to always be responsive to a clinical need. 

Some projects that we have initiated at Texas Children's Hospital, following this paradigm, include:

  • Vascular heterogeneity and CSC distributions in neuroblastoma using novel contrast agents (In collaboration with Dr. Jason Shohet)
  • Surgical planning using 3D printed models of anatomy (In collaboration with Dr. Scott Rosenfeld)
  • Imaging necrotizing enterocolitis using a novel NIR probe (In collaboration with Dr. Douglas Burrin)
  • Targeting FA-OSCC CSC’s using novel aptamer targeted nanoparticles (In collaboration with Dr. Vigneswaran Nadarajah)
  • Vascular heterogeneity in MoyaMoya disease (In collaboration with Dr. Dianna Milewicz)
  • Vascular and Molecular Imaging of the Placenta in Health and Disease (In collaboration with Drs. Wesley Lee, Anil Shetty and Jimmy Espinoza)

Key recent publications:

1. Starosolski, Z. et al. Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent. Sci. Rep. 5, 10178 (2015).

2. Annapragada, A. Advances in Nanoparticle Imaging Technology for Vascular Pathologies. Annu. Rev. Med. 66, 177–193 (2015).

3. Sabapathy, D. G. et al. Radiographic Screening of Infants and Young Children With Genetic Predisposition for Rare Malignancies: DICER1 Mutations and Pleuropulmonary Blastoma. AJR American journal of roentgenology, 204,W475–82 (2015).