Yuxin Fan, MD, PhD, FACMG
Medical Director of John Welsh Cardiovascular Diagnostic Laboratory
Associate Professor, Pathology & Immunology and Pediatrics, Baylor College of Medicine
Languages: English
Departments:
Get to know Yuxin Fan, MD, PhD, FACMG
Personal Statement
I always do my best to provide the best clinical molecular genetic diagnostic services possible.
Clinical Interests
My clinical interests mainly involve in the development and implantation of molecular genetic diagnosis of inherited human diseases, especially cardiovascular disorders using Sanger sequencing, next generation sequencing (NGS) and array-based comparative genomic hybridization (aCGH). I am also interested in developing viral testing for the molecular diagnosis of myocarditis and for the molecular monitoring of heart transplant rejection.
Education
| School | Education | Degree | Year |
|---|---|---|---|
| University of Washington | Fellowship | Clinical Molecular Genetics | 2006 |
| Fred Hutchinson Cancer Research Center | Post-doctoral Fellowship | Postdoctoral Research | 2003 |
| University of Washington | Post-doctoral Fellowship | Postdoctoral Research | 2000 |
| Fudan University | PhD | Doctor of Philosophy | 1999 |
| Anhui University of Chinese Medicine | Masters | Master of Science | 1994 |
| Anhui University of Chinese Medicine | MBBS | Bachelor of Medicine, Bachelor of Surgery | 1987 |
Organizations
| Organization Name | Role |
|---|---|
| American Academy of Pediatrics (AAP) | Fellow |
| American Board of Medical Genetics and Genomics (ABMGG) | Diploma |
| American College of Medical Genetics and Genomics (ACMG) | Fellow |
| American Heart Association (AHA) | Silver Member |
| American Society of Human Genetics (ASHG) | Member |
| Association for Molecular Pathology (AMP) | Member |
| College of American Pathologists (CAP) | Inspection Team, Team Leader and Member |
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research interests
My research interests have been focused on cardiovascular genetics, especially on the genetic screening for new genes related to cardiovascular disease and on the understating of mechanisms behind inherited cardiomyopathy using cellular and knock-in/out animal models.
Wang G, Knight L, Ji R, Lawrence P, Kanaan U, Li L, Das A, Cui B, Zou W, Penny DJ, Fan Y. Early onset severe pulmonary arterial hypertension with 'two-hit' digenic mutations in both BMPR2 and KCNA5 genes.Int J Cardiol 2014 Aug 28. pii: S01675273(14)01671-4. doi: 10.1016/j.ijcard.2014.08.124. [Epub ahead of print].
Chiang DY, Kim JJ, Valdes SO, de la Uz C, Fan Y, Orcutt J, Domino M, Smith M, Wehrens XH, Miyake CY. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture. Circ Arrhythm Electrophysiol 2015 Oct;8(5):1105-12. doi: 10.1161/CIRCEP.115.003098. Epub 2015 Jun 25.
Wang G, Fan R, Ji R, Zou W, Penny DJ, Varghese N, Fan Y. Novel homozygous BMP9 nonsense mutation causes pulmonary arterial hypertension. BMC Pulm Med 2016 Jan 22;16(1):17. doi: 10.1186/s12890-016-0183-7.
Landstrom AP, Dailey-Schwartz AL, Rosenfeld JA, Yang Y, McLean MJ, Miyake CY, Valdes SO, Fan Y, Hugh D. Allen HD MD, Penny DJ, Kim JJ. Interpreting incidentally identified variants in genes associated with catecholaminergic polymorphic ventricular tachycardia in a large cohort of clinical whole exome genetic test referrals. 2017 Apr;10(4). pii: e004742. doi: 10.1161/ Circ Arrhythm Electrophysiol CIRCEP.116.004742.
Guo DC, Hostetler EM, Fan Y, Kulmacz RJ, Zhang D; GenTAC Investigators, Nickerson DA, Leal SM, LeMaire SA, Regalado ES, Milewicz DM. Heritable Thoracic Aortic Disease Genes in Sporadic Aortic Dissection. J Am Coll Cardiol 2017 Nov 28;70(21):2728-2730. doi: 10.1016/j.jacc.2017.09.1094.
Guoliang Wang, Wenxin Zou, Ruirui Ji, Vivian Niewiadonski, Jianping Li, Daniel J. Penny, Yuxin Fan. "Application of NGS in the Diagnosis of Cardiovascular Genetic Diseases" in Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders (978-3-319-56416-6 330836_1_En) edited by Lee-Jun Wong, et al published by Springer Nature,2017. (Book Chapter).
Ezekian J, Clippinger S, Garcia J, Yang Q, Denfield S, Jeewa A, Dreyer J, Zou W, Fan Y, Allen H, Kim J, Greenberg M, Landstrom A. The variant R94C in TNNT2-encoded troponin T predisposes to pediatric restrictive cardiomypathy and sudden death through impaired thin filament relaxation result