Jennifer Clinton, PhD
Assistant Professor of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine
Phone:
832-824-4612
Languages: English
Departments:
Office location:
1102 Bates Avenue
Houston, TX 77030
Get to know Jennifer Clinton, PhD
Personal Statement
My research focus aims to mitigate mosquito-borne diseases that negatively impact the world’s most vulnerable populations. I incorporate both basic and translational research approaches to better understand arboviral pathogenesis and develop therapeutics. By exploiting host immune responses against arboviruses such as Zika, chikungunya, or West Nile viruses, we can assess current vaccine efficacy as well as create novel routes of therapeutic intervention.
Education
| School | Education | Degree | Year |
|---|---|---|---|
| California State University | Bachelors | Bachelor of Science in Biological Science | 2015 |
| Baylor College of Medicine | PhD | Doctorate in Molecular Virology and Microbiology | 2020 |
Honors and awards
- 2019
-
Kelly Kahl Woodard Award for Outstanding Achievement in Scientific Scholarship, Research, and Leadership
- 2015
-
MARC Outstanding Scholar Award
- 2014
-
L. Jack Bradshaw Scholarship in Immunology
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research interests
arboviral pathogenesis, vaccine development, innate immunity, cytokine signaling
Spencer Clinton JL, Vogt MB, Kneubehl AR, Hibl BM, Paust S, Rico-Hesse R. Sialokinin in mosquito saliva shifts human immune responses towards intracellular pathogens. PLoS Negl Trop Dis. 2023 Feb 3;17(2):e0011095. doi: 10.1371/journal.pntd.0011095. PMID: 36735632; PMCID: PMC9897557.
Spencer Clinton JL, Hoornweg TE, Tan J, Peng R, Schaftenaar W, Rutten VPMG, de Haan CAM, Ling PD. EEHV1A glycoprotein B subunit vaccine elicits humoral and cell-mediated immune responses in mice. Vaccine. 2022 Aug 19;40(35):5131-5140. doi: 10.1016/j.vaccine.2022.07.016. Epub 2022 Jul 22. PMID: 35879117.
Pursell T, Spencer Clinton JL, Tan J, Peng R, Ling PD. Modified vaccinia Ankara expressing EEHV1A glycoprotein B elicits humoral and cell-mediated immune responses in mice. PLoS One. 2022 Mar 21;17(3):e0265424. doi: 10.1371/journal.pone.0265424. PMID: 35312707; PMCID: PMC8936464.
Hibl BM, Dailey Garnes NJM, Kneubehl AR, Vogt MB, Spencer Clinton JL, Rico-Hesse RR. Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects. PLoS Negl Trop Dis. 2021 Jun 9;15(6):e0009427. doi: 10.1371/journal.pntd.0009427. Erratum in: PLoS Negl Trop Dis. 2022 Jun 2;16(6):e0010503. PMID: 34106915; PMCID: PMC8189471.
Spencer Clinton JL, Tran LL, Vogt MB, Rowley DR, Kimata JT, Rico-Hesse R. IP-10 and CXCR3 signaling inhibit Zika virus replication in human prostate cells. PLoS One. 2020 Dec 30;15(12):e0244587. doi: 10.1371/journal.pone.0244587. PMID: 33378361; PMCID: PMC7773246.
Vogt MB, Lahon A, Arya RP, Kneubehl AR, Spencer Clinton JL, Paust S, Rico-Hesse R. Mosquito saliva alone has profound effects on the human immune system. PLoS Negl Trop Dis. 2018 May 17;12(5):e0006439. doi: 10.1371/journal.pntd.0006439. PMID: 29771921; PMCID: PMC5957326.
Spencer JL, Lahon A, Tran LL, Arya RP, Kneubehl AR, Vogt MB, Xavier D, Rowley DR, Kimata JT, Rico-Hesse RR. Replication of Zika Virus in Human Prostate Cells: A Potential Source of Sexually Transmitted Virus. J Infect Dis. 2018 Jan 30;217(4):538-547. doi: 10.1093/infdis/jix436. PMID: 28968863; PMCID: PMC5853941.