Chellakkan S. Blesson, M.Phil., Ph.D., TS/HCLD (ABB)
Lab Director
Associate Professor, Baylor College of Medicine
Languages: English
Departments:
Get to know Chellakkan S. Blesson, M.Phil., Ph.D., TS/HCLD (ABB)
Personal Statement
Dr. Blesson has over two decades of experience in the field of Reproductive Biology and Endocrinology. He is a board certified Technical Supervisor and High Complexity-Clinical Laboratory Director by the American Board of Bioanalysis in Andrology and Embryology. He is also Associate Professor at Baylor College of Medicine.
Dr. Blesson is involved in translational research and teaching. He is passionate about bringing his research expertise to improve healthcare. He also teach and mentor residents and fellows. He has vast experience in sex hormone signaling and its relevance in reproduction and metabolism. As an IVF laboratory director, he has made it his mission to improve reproductive success by (i) bringing new cutting edge assisted reproductive technologies and to apply it to our patients, (ii) understanding the mechanisms of reproductive diseases and (iii) fostering an environment of knowledge driven patient care and education at Family Fertility Center. He is also involved in improving quality and developing novel technologies for fertility treatments.
His research team is working towards understanding the developmental origins of diseases and its role in reproduction and metabolism. Adverse uterine environment during critical period of early development predisposes the individual to increased risk of metabolic diseases in adult life. His team is currently investigating the roles of hormones and nutrition during early development and its implication in the developmental origin of adult diseases such as polycystic ovary syndrome (PCOS) and type 2 diabetes. His team investigate the effects of PCOS on ovary, oocytes and embryos. They are currently studying the role of androgens in mitochondrial function and metabolism. They have also developed a novel low protein programmed lean type 2 diabetic rat model to investigate the role of developmental programming of type 2 diabetes. He has published many articles in peer-reviewed journals and his work has been presented in several national and inter-national conferences.
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Gannon A.L, Chacko S.K, Didelija I, Marini J.C. and Blesson C.S. Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model. JoVE (2022) 181, e62991.
Vipin, V.A, Betancourt A, Smith C, Yallampalli C and Blesson C.S. Prenatal low protein diet affects mitochondrial structure and function in the skeletal muscle of adult female offspring. Nutrients (2022) 14, 1158.
Chappell N.C, Gibbons W.E. and Blesson C.S. Pathology of Hyperandrogenemia in the Oocyte of Polycystic Ovary Syndrome. Steroids (2022) 180: 108989.
Barsky M, Merkison J, Hosseinzadeh P, Yang L, Bruno-Gaston J, Dunn J, Gibbons W.E and Blesson C.S. Fetal Programming of Polycystic Ovary Syndrome: Effects of Androgen Exposure on Prenatal Ovarian Development. Journal of Steroid Biochemistry and Molecular Biology (2021) 207 (3), 105830.
Hosseinzadeh P., Barsky M., Gibbons W.E., Blesson C.S. Polycystic Ovary Syndrome and the Forgotten Uterus. F&S Reviews (2021) 2: (1), 11-20.
Chappell N.R., Zhou B., Hosseinzadeh P., Schutt A.K., Gibbons W.E., Blesson C.S. Hyperandrogenemia alters Mitochondrial Function in an Obese PCOS Mouse Model. F&S Science (2020). 2 (1), 101-112.
Chappell N.R, MD, Barsky, M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, Gibbons W.E and Blesson C.S. Embryos from Polycystic Ovary Syndrome (PCOS) Patients with Hyperandrogenemia Reach Morula Stage Faster than Controls. Fertility and Sterility Reports (2020) 1 (2), 125-132.