Andrew DiNardo, MD, PhD
- Adult Infectious Disease
Assistant Professor, Global Immigrant Health, Baylor College of Medicine
Email: Andrew.Dinardo@bcm.edu
Languages: English
Departments:
Office location:
1102 Bates Avenue
Houston, TX 77030
Get to know Andrew DiNardo, MD, PhD
Personal Statement
Dr. DiNardo studies the epigenetic regulation of host immunity to Tuberculosis and helminth-TB co-infections.
Clinical Interests
Tuberculosis
Education
| School | Education | Degree | Year |
|---|---|---|---|
| Radboud University | PhD | Doctor of Philosophy | 2022 |
| Baylor College of Medicine | Fellowship | Infectious Disease | 2015 |
| University of Pennsylvania Health System | Residency | Internal Medicine | 2010 |
| Wayne State University School of Medicine | Medical School | Doctor of Medicine | 2007 |
| Emory University | Bachelors | Bachelor of Arts | 2002 |
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research interests
Post-infectious epigenetic scars; TB endotypes; metabolic-epigenetic rheostats regulating inflammation
Bobak C, Abhimanyu, Natarajan H, Gandhi T, Grimm T, Nishiguchi T, Koster K, Carrerro S, Dlamini Q, Kahari J, Mtetwa G, Cirillo JD, O’Malley JO, Hill J, Coarfa C, DiNardo AR.* DNA hypermethylation, cellular senescence, and premature epigenetic aging in humans and guinea pigs with Tuberculosis. Aging January 2022. PMID 35256539; DOI: 10.18632/aging.203936
DiNardo AR*, Netea MG, Musher D. Post-infectious epigenetic immune modifications: a double-edged sword. NEJM; 2021. PMID 33471978. DOI: 10.1056/NEJMra2028358
DiNardo AR*, Nishiguchi T, Grimm SL, Schlesinger LS, Graviss EA, Cirilo JD, Coarfa C, Mandalakas AM, Heyckendorf J, Kaufmann SHE, Lange C, Netea MG, Crevel RV. Tuberculosis endotypes to guide stratified host-directed therapy. Cell Med. 2021. PMID 34693385. DOI: 10.1016/j.medj.2020.11.003
DiNardo AR,* Gandhi T, Heyckendorf J, Rajapakshe K, Grimm SL, Nishiguchi T, Reimann M, Kahari J, Dlamini Q, Lange C, Goldmann T, Marwitz S, Cirillo JD, Kaufmann SHE, Netea MG, Crevel RV, Mandalakas AM, Coarfa C. Gene expression signatures identify biologically and clinically distinct endotypes in Tuberculosis. ERJ January 2022. PMID 35169026; DOI: 10.1183/13993003.02263-2021
DiNardo AR,* Rajapakshe K, Nishiguchi T, Grimm SL, Mtetwa G, Dlamini Q, Kahari J, Mahapatra S, Kay A, Maphalala G, Mace, EM, Makedonas, G, Cirillo JD, Netea MG, van Crevel R, Coarfa C, Mandalakas AM. DNA hyper-methylation during Tuberculosis dampens host immune responsiveness. 2020. Journal of Clinical Investigation; 2020. PMID 3215282; DOI: 10.1172/JCI134622
DiNardo AR,* Nishiguchi T, Mace EM, Rajapakshe K, Mtetwa G, Kay A, Maphalala G, Secor WE, Mejia R, Orange JS, Coarfa C, Bhlalla KN, Graviss EA, Mandalakas AM, Makedonas G. Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. J Immunol 2018. PMID 29752313; DOI: 10.4049/jimmunol.1800101
DiNardo AR, Mace EM, Lesteberg K, Mandalakas AM, Cirillo JD, Graviss EA, Orange JS, Makedonas G. Schistosomiasis Egg Antigen Decreases Tuberculosis-Specific CD4 T cell Effector Function with Concomitant Arrest of macrophage Phago-Lysosome Maturation. Journ of Infect Dis; 2016 April 18; PMID: 27389351