Katherine King, MD, PhD
- Infectious Disease
Co-Director, Medical Scientist Training Program
Associate Vice Chair of Research, Department of Pediatrics
Professor, Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine
Phone:
832-824-4330
Fax:
832-825-4347
Languages: English
Office locations:
1102 Bates Avenue
Houston, TX 77030
Get to know Katherine King, MD, PhD
Personal Statement
I am a physician-scientist committed to providing excellent care to patients while advancing discoveries in the laboratory.
Clinical Interests
General pediatric infectious disease, antibiotic-associated neutropenia
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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Research interests
Dr. King's research is focused on investigating the effects of infection and inflammation on hematopoietic stem cell biology. These findings will have implications for the prevention and treatment of blood disorders related to inflammatory conditions, stem cell transplant outcomes, and immunity.
Hormaechea-Agulla D, Matatall K, Le DT, Kain B, Long X, Kus P, Jaksik R, Challen GA, Kimmel M, and King KY. (2021) Chronic infection drives Dnmt3a-loss of function clonal hematopoiesis via IFNg signaling. Cell Stem Cell. 28(8):1428-1442. PMID: 33743191.
Morales-Mantilla DE, King KY. (2022) FGD5 marks a subpopulation of hematopoietic stem and progenitor cells that resist interferon-gamma-mediated differentiation. Exp. Hematol. 112-113:35-43. PMID: 35768035.
Yan H, Walker FC, Ali A, Han H, Tan L, Veillon L, Lorenzi PL, Baldridge MT, and King KY. (2022) The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling. Blood Advances. 6(6):1754-65. PMID: 35143611.
Le DT, Florez MA, Kus P, Tran BT, Kain B, Zhu Y, Christensen K, Jain A, Malovannaya A, and King KY. (2023) BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. iScience 26(2):106059 PMID:36824275.
Florez M, Matatall KA, Jeong Y, Ortinau L, Shafer P, Lynch A, Jaksik R, Kimmel M, Park D, and King KY. (2020) IFNg mediates hematopoietic stem cell activation and niche relocalization through BST2. Cell Reports. 33(12):108530. PMID: 33357430.
Kain BN, Tran BT, Luna PN, Cao R, Le DT, Florez MA, Maneix L, Toups JD, Morales-Mantilla DE, Koh S, Han H, Jaksik R, Huang Y, Catic A, Shaw CA, King KY. (2023) Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models. IScience online ahead of print. https://doi.org/10.1016/j.isci.2023.
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