Anthony William Zoghbi, MD

Dr. Anthony Zoghbi is an Assistant Professor of Psychiatry and Genetics at Baylor College of Medicine and Co-Director of the Texas Children’s Hospital Better Together Biobank. As Chief of Neuropsychiatric Genetics at Baylor, his research integrates human genomics, psychiatry, and computational biology to uncover the genetic and immune mechanisms underlying severe mental illness. Dr. Zoghbi’s work focuses on translating discoveries from large-scale sequencing and biobank initiatives into improved diagnostics and treatments for neuropsychiatric and neurodevelopmental disorders. He leads national collaborations investigating the genomic and autoimmune basis of schizophrenia, obsessive-compulsive disorder, and bipolar disorder.

Dr. Zoghbi completed his medical degree at Baylor College of Medicine and psychiatry residency at Columbia University, where he also served as Chief Resident and completed a T32 fellowship in schizophrenia genetics under the mentorship of Dr. David Goldstein. His research has been supported by the National Institute of Mental Health and the Valour Foundation, among others. At Texas Children’s, Dr. Zoghbi helps guide the biobank’s scientific direction and ethical integration of genomic data to advance precision medicine for children and families. He has been recognized with multiple honors, including the Baylor Outstanding Educator Award and the SOBP Chair’s Choice Award, and is passionate about mentoring the next generation of physician-scientists at the intersection of psychiatry and genetics.

Personal Statement

I am dedicated to advancing precision medicine by building bridges between patient care, research, and data science. Through the Better Together Biobank, we hope to transform everyday clinical encounters into opportunities for discovery by linking biological samples with clinical data to better understand health and disease across all pediatric populations. My goal is to help create a resource that empowers researchers and clinicians alike to generate insights that ultimately improve care for every child and family at Texas Children’s Hospital.

Education

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Dhindsa RS, Weido BA, Dhindsa JS, …Zoghbi, AW. Genome-wide prediction of dominant and recessive neurodevelopmental disorder-associated genes. The American Journal of Human Genetics. 2025;112(3):693-708. doi:10.1016/j.ajhg.2025.02.001

McClellan JM*, Zoghbi AW*, Buxbaum JD, et al. An Evolutionary Perspective on Complex Neuropsychiatric Disease. Neuron. 2024;112(1):7-24. doi:10.1016/j.neuron.2023.10.037

Zoghbi AW, Lieberman JA, Girgis RR. The neurobiology of duration of untreated psychosis: a comprehensive review. Molecular Psychiatry. 2023;28(1):168-190. doi:10.1038/s41380-022-01718-0

Zoghbi, AW, Dhindsa RS, Goldberg TE, Mehralizade A, Wang X, Harms MB, Lieberman JA, Markx S, Goldstein DB. (2021) High-impact rare genetic variants in severe schizophrenia. Proceedings of the National Academy of Sciences. 118, e2112560118

Dhindsa RS, Zoghbi AW, Krizay DK, Vasavda C, Goldstein DB. A transcriptome-based drug discovery paradigm for neurodevelopmental disorders. Annals of Neurol. 2021;89(2):199-211. doi:10.1002/ana.25950