Sickle Cell and Thalassemia Transplant

Where Specialized Care, Innovation, and Compassion Come Together

What Sets Us Apart

The Sickle Cell and Thalassemia Transplant Program at Texas Children’s Hospital provides care that supports the whole child and family from early evaluation through long-term recovery. Our approach is built on teamwork, thoughtful communication, and continuous improvement to make the transplant journey clearer, safer, and more supportive.

Key characteristics that set our Program apart are listed below:

One Coordinated Care Team
Specialists in sickle cell care, bone marrow transplant, neurology, kidney, lung, heart, psychology, and social work work together as one team—so families receive clear guidance and coordinated care at every step.

Research-Informed Care with Access to New Therapies
Patients may have access to emerging treatments such as gene therapy and haploidentical transplantation, supported by participation in national research collaborations including STAR (curesicklenow.org). These partnerships help us continuously refine care and improve safety.

Care That Honors Every Family
We recognize that trust is built over time. Our team is experienced in caring for culturally diverse community and is committed to respectful, transparent communication.

Support Beyond Transplant
Our survivorship program supports children as they return to school, reconnect with peers, and transition to adult care—while also addressing emotional, social, and mental well-being.

Become a Patient

Approaches

We provide integrated, patient-centered care throughout the entire transplant journey. Each treatment plan is tailored to the individual child and supported by proactive monitoring and comprehensive services, including neuroprotection, lung and kidney monitoring, infection prevention, fertility preservation, and mental health support.

We offer multiple transplant and curative therapy options based on each patient’s medical needs and goals, including:

Myeloablative Matched-Sibling Hematopoietic Stem Cell Transplant (HSCT)
Haploidentical (Half-Matched) HSCT using post-transplant cyclophosphamide (clinical trial coming soon)
Reduced-Intensity Conditioning Transplant for older or higher-risk patients using matched related or unrelated donors
Gene Therapy for Hemoglobinopathies

Our goal is to deliver the right therapy, at the right time, with careful attention to both short-term safety and long-term health.

Mission

At the Sickle Cell Transplant Program at Texas Children’s Cancer and Hematology Center, we are dedicated to:

Comprehensive, Personalized Care

We deliver expert diagnosis and individualized treatment through a team-based, multidisciplinary approach from early evaluation through long-term follow-up and transition to adult care.

Innovation and Research

We advance care through ongoing research, clinical trials, and access to emerging transformative therapies, helping bring new options and safer treatments to patients with sickle cell disease and thalassemia.

Education and Empowerment

We train the next generation of leaders in sickle cell transplant care while empowering patients and families with clear information, shared decision-making, and access to the latest innovations.