Updates

Texas Children's Cancer and Hematology Center

 Clinical Trials and Novel Therapies

As a recognized leader in clinical and laboratory research, we offer clinical trials and novel therapies for a wide range of children’s cancer and blood disorders.

Most of our patients are involved in a clinical trial or study. With over 250 active therapeutic clinical trials, our >350 researchers and 47 laboratories are pioneering the translation of discoveries to the clinic. As part of larger teams, our experts collaborate with the pharmaceutical industry and participate in major pediatric cancer and blood disorder cooperative clinical trial groups, like the Children’s Oncology Group (COG). See below for our current and featured trials.

Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen (MAGENTA)

In this study investigators will attach the CD5 chimeric receptor with CD28 added to it to the patient's T cells or the previous bone marrow transplant donor's T cells. The investigators will then test how long the cells last.

Read More

Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)

The antibody used in this study targets CD19, CD20 and CD22. This antibody sticks to ALL cells because of a substance on the outside of these cells called CD19, CD20 and/or CD22. For this study, the antibody to CD19, CD20 and CD22 has been changed so that instead of floating free in the blood, it is now joined to the T cells.

Read More

A Study to find the Highest Dose of Imetelstat in Combination with Fludarabine and Cytarabine for Patients with AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy (PEPN2312)

This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that is refractory or recurrent.

Read More

For a complete list of clinical trials offered at Texas Children's Hospital, visit clinicaltrials.gov

Top 10 in Cancer

Proud to be ranked one of the best children’s cancer centers in the country by U.S. News & World Report for nine consecutive years

See Rankings