Texas Children's Researchers Publish Groundbreaking Paper on Childhood Brain Tumors

Exciting news from TexasChildrensHospital and Toronto’s SickKids! Researchers discovered that blocking the KCNB2 gene can slow the growth of medulloblastoma, the most common malignant brain tumor in children. This breakthrough, published in Developmental Cell, could lead to next-generation treatments for childhood brain cancer.

Link to article: https://www.sciencedirect.com/science/article/abs/pii/S1534580725000012?via%3Dihub

Dr. Xi Huang and Dr. Michael Taylor, along with their teams, used a genetically engineered preclinical model to identify key genes linked to tumor growth. By targeting the KCNB2 gene, they were able to reduce tumor growth without affecting healthy cells. 

The study was supported by the SickKids Industry Partnerships & Commercialization office, the Sontag Foundation, the Ontario Early Researcher Award program, the Canadian Cancer Society, the Cancer Research Society, NSERC, the American Brain Tumor Association, and many others. For more details, read the full paper in Developmental Cell.