Taylor identifies new immunotherapy approaches to medulloblastoma

Findings published in Cell led by Dr. Michael Taylor identified a population of stem-like cells that initiate and maintain Group 3 medulloblastoma in the developing brain.

The team found that the cancer stem-like cells, which express the protein Protogenin, are localized to a specific brain region in the cerebellum called the rhombic lip. 

In a preclinical model of Group 3 medulloblastoma, the team targeted these stem-like cancer cells using CAR T-cell immunotherapy, producing effective therapeutic results.

Link to original research article: https://doi.org/10.1016/j.cell.2024.06.011

The research team comprised investigators at Texas Children’s Cancer and Hematology Center, Baylor College of Medicine, The Hospital for Sick Children, and other collaborating institutions. Dr. Michael D. Taylor, Professor in the Departments of Pediatrics, Section Hematology-Oncology; and Neurosurgery at Baylor and Texas Children’s.