Katherine Y. King, MD, PhD
- Infectious Disease
Pediatric Infectious Diseases Attending
Professor, Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine
Co-Director, Medical Scientist Training Program, Baylor College of Medicine
Phone:
832-824-4330
Idiomas: English
Office location:
Texas Medical Center
6701 Fannin Street
17th Floor
Houston, TX 77030
Get to know Katherine Y. King, MD, PhD
Dr. King is a Physician Scientist who specializes in infectious diseases diagnosis and treatment in children. Her extramurally funded research program investigates the impact of infection and inflammation on bone marrow function, including hematopoietic stem cells. Her research, published in high profile journals such as Cell Stem Cell and Nature. Current projects in the lab include:
Impact of Infection and Inflammation on Hematopoiesis: We are studying how infections affect the quiescence, epigenetic programming, and differentiation of hematopoietic stem cells and their progeny. Our studies may lead to ways to prevent bone marrow suppression after chronic infections or enhance innate immune memory to combat future pandemics. Funding to support this project: NIH R35, 2021-2028.
The Role of Infection and Inflammation in Clonal Hematopoiesis: We are studying how the differential responses of hematopoietic stem cells to inflammation contribute to clonal competition and emergence of leukemia. These studies provide a mechanistic understanding of how infections affect cancer risk. Funding to support this project: NIH P01, 2022-2027.
Microbiota-dependent Regulation of Primitive Hematopoiesis: We demonstrated that the intestinal microbiome and associated type I interferon signaling is critical for normal hematopoiesis. Our current work will define the molecular pathways through which the microbiome signals to support normal blood production, including to support immune recovery for bone marrow transplant patients.
[person:personal_statement]
I strive to collaborate with patients, families, and care teams to provide optimal care for the most challenging cases. I bring an evidence-based perspective to all that I do.
Intereses Clinicos
General pediatric infectious disease, antibiotic-associated neutropenia
Educacion
| School | Education | Degree | Year |
|---|---|---|---|
| Baylor College of Medicine | Fellowship | Pediatric Infectious Diseases | 2010 |
| Baylor College of Medicine | Residency | Pediatrics | 2006 |
| Washington University in St. Louis | PhD | Doctor of Philosophy in Molecular Microbiology and Microbial Pathogenesis | 2003 |
| Washington University in St. Louis | Medical School | Doctor of Medicine | 2003 |
| Harvard and Radcliffe Colleges | Bachelors | Bachelor of Biochemical Sciences | 1996 |
Organizaciones
| Nombre de la Organizacion | Rol |
|---|---|
| American Pediatric Society | Elected Member |
| American Society for Clinical Investigation | Elected Member |
| American Society of Hematology | Member |
| Infectious Diseases Society of America | Member |
| International Society for Experimental Hematology | Board Member |
| Pediatric Infectious Diseases Society | Member |
| Society for Pediatric Research | Member |
Board Certifications
| Title |
|---|
| American Board of Pediatrics in Pediatric Infectious Diseases |
| American Board of Pediatrics, FAAP |
Honors and awards
- 2025
-
E. Mead Johnson Award, Society of Pediatric Research
- 2022
-
DeBakey Research Award, Baylor College of Medicine
- 2022
-
Research Mentor Award, Texas Children’s Hospital
- 2021
-
R35 Emerging Investigator Award National Heart, Lung, and Blood Institute
- 2019
-
Presidential Early Career Award for Scientist and Engineers, National Science Foundation
- 2007
-
Chief Resident, Baylor College of Medicine
* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.
Highlights
Research interests
Impact of infection and inflammation on hematopoietic stem cell biology
Kain BN, Tran BT, Luna PN, Cao R, Le DT, Florez MA, Maneix L, Toups JD, Morales-Mantilla DE, Koh S, Han H, Jaksik R, Huang Y, Catic A, Shaw CA, King KY. Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models. iScience, 2023, 26(9):107596. PMID 37664586
Le DT, Florez MA, Kus P, Tran BT, Kain B, Zhu Y, Christensen K, Jain A, Malovannaya A, and King KY. BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection. iScience, 2023, 26(2):106059 PMID:36824275
Yan H, Walker FC, Ali A, Han H, Tan L, Veillon L, Lorenzi PL, Baldridge MT, and King KY. The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling. Blood Advances, 2022, 6(6):1754-65. PMID: 35143611
Morales-Mantilla DE, Kain B, Le D, Flores AR, Paust S, and King KY. Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells. eLife, 2022, 11:e74561. PMID: 35166205
Hormaechea-Agulla D, Matatall K, Le DT, Kain B, Long X, Kus P, Jaksik R, Challen GA, Kimmel M, and King KY. Chronic infection drives Dnmt3a-loss of function clonal hematopoiesis via IFNg signaling. Cell Stem Cell, 2021, 28(8):1428-1442. PMID: 33743191
Florez M, Matatall KA, Jeong Y, Ortinau L, Shafer P, Lynch A, Jaksik R, Kimmel M, Park D, and King KY. IFNg mediates hematopoietic stem cell activation and niche relocalization through BST2. Cell Reports, 2020, 33(12):108530. PMID: 33357430
Josefsdottir KS, Baldridge MT, Kadmon CS, and King KY. Antibiotics impair murine hematopoiesis by depleting intestinal microbiota. Blood, 2017, 129(6):729-739. PMID: 27879260