Updates

ECMO (Extracorporeal Membrane Oxygenation)

 Research

Peer-Reviewed publications by ECMO team members

Current team members are listed in bold face type

  1. Steppan DA, Coleman RD, Viamonte HK, Hanson SJ, Carroll MK, Klein OR, Cooke KR, Spinella PC, Steiner ME, Loftis LL, Bembea MM; Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Extracorporeal Life Support Organization (ELSO). Outcomes of pediatric patients with oncologic disease or following hematopoietic stem cell transplant supported on extracorporeal membrane oxygenation: The PEDECOR experience. Pediatr Blood Cancer. 2020 Jun Epub ahead of print. PMID: 32519430.
  2. Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, McKiernan CA, Heidemann SM, Kleinman LC, Sen AI, Hall MW, Priestley MA, McGuire JK, Boukas K, Sharron MP, Burns JP; International COVID-19 PICU Collaborative. Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. 2020 May 11. Epub ahead of print. PMID: 32392288.
  3. Ramanathan K, Tan CS, Rycus P, Anders M, Lorusso R, Zhang JJY, MacLaren G. Extracorporeal Membrane Oxygenation in Pregnancy: An Analysis of the Extracorporeal Life Support Organization Registry. Crit Care Med. 2020 May;48(5):696-703. PMID: 32191415
  4. Kataria-Hale J, Fernandes CJ, Speer ME. Pneumopericardium in the neonate: a case report. Perfusion. 2020 May;35(4):360-362. Epub 2019 Aug 15. PMID: 31416399.
  5. Lasa JJ, Gaies M, Bush L, Zhang W, Banerjee M, Alten JA, Butts RJ, Cabrera AG, Checchia PA, Elhoff J, Lorts A, Rossano JW, Schumacher K, Shekerdemian LS, Price JF. Epidemiology and Outcomes of Acute Decompensated Heart Failure in Children. Circ Heart Fail. 2020 Apr;13(4): Epub 2020 Apr 17. PMID: 32301336;
  6. Gleeson EI, Cunningham ME, Burgman C, Musick MA, Thomas JA, Gardner GC, Kukreja KU, Vogel AM. A multidisciplinary approach to VA ECMO cannulation in children. J Pediatr Surg. 2020 Mar 11:S0022-3468(20)30197-4. Epub ahead of print. PMID: 32234319.
  7. Olson TL, O'Neil ER, Ramanathan K, Lorusso R, MacLaren G, Anders MM. Extracorporeal membrane oxygenation in peripartum cardiomyopathy: A review of the ELSO Registry. Int J Cardiol. 2020 Jul 15;311:71-76. Epub 2020 Mar 3. PMID: 32321653.
  8. Coleman RD, Goldman J, Moffett B, Guffey D, Loftis L, Thomas J, Shekerdemian LS. Extracorporeal Membrane Oxygenation Mortality in High-Risk Populations: An Analysis of the Pediatric Health Information System Database. ASAIO J. 2020 Mar;66(3):327-331. PMID: 31045920.
  9. O'Halloran CP, Thiagarajan RR, Yarlagadda VV, Barbaro RP, Nasr VG, Rycus P, Anders M, Alexander PMA. Outcomes of Infants Supported With Extracorporeal Membrane Oxygenation Using Centrifugal Versus Roller Pumps: An Analysis From the Extracorporeal Life Support Organization Registry. Pediatr Crit Care Med. 2019 Dec;20(12):1177-1184. PMID: 31567621.
  10. Ruth A, Meador M, Hui R, Loftis L, Teruya J. Acquired von Willebrand Syndrome in Pediatric Extracorporeal Membrane Oxygenation Patients: A Single Institution's Experience. Pediatr Crit Care Med. 2019 Oct;20(10):980-985. PMID: 31246745.
  11. Puri K, Anders MM, Tume SC, Cabrera AG, Heinle JS, Causey JC, Wang Y, Moffett BS, Shekerdemian LS. Characteristics and Outcomes of Pediatric Patients Supported With Ventricular Assist Device-A Multi-Institutional Analysis. Pediatr Crit Care Med. 2019 Aug;20(8):744-752. doi: 10.1097/PCC.0000000000001966. PMID: 31162368.
  12. Sayad E, Coleman RD, Silva-Carmona MD. Diagnosis and treatment of cryptogenic organizing pneumonia in a child on ECMO. Pediatr Pulmonol. 2020 Jan;55(1):20-22. Epub 2019 Aug 30. PMID: 31469247.
  13. Coleman RD, Chartan CA, Qureshi AM, Shekerdemian LS. Left Atrial Decompression on Venoarterial Extracorporeal Membrane Oxygenation: Getting to the Heart of the Matter. Pediatr Crit Care Med. 2019 Aug;20(8):780-781. PMID: 31397811.
  14. Style CC, Olutoye OO, Verla MA, Lopez KN, Vogel AM, Lau PE, Cruz SM, Espinoza J, Fernandes CJ, Keswani SG, Lee TC. Fetal echocardiography (ECHO) in assessment of structural heart defects in congenital diaphragmatic hernia patients: Is early postnatal ECHO necessary for ECMO candidacy? J Pediatr Surg. 2019 May;54(5):920-924. Epub 2019 Feb 20. PMID: 30954228.
  15. Cairo SB, Arbuthnot M, Boomer LA, Dingeldein MW, Feliz A, Gadepalli S, Newton CR, Ricca R Jr, Vogel AM, Rothstein DH; American Pediatric Surgical Association, Surgical Critical Care Committee. Controversies in extracorporeal membrane oxygenation (ECMO) utilization and congenital diaphragmatic hernia (CDH) repair using a Delphi approach: from the American Pediatric Surgical Association Critical Care Committee (APSA-CCC). Pediatr Surg Int. 2018 Nov;34(11):1163-1169. Epub 2018 Aug 21. PMID: 30132059.
  16. Steen EH, Lee TC, Vogel AM, Fallon SC, Fernandes CJ, Style CC, Verla MA, Balaji S, Olutoye OO, Keswani SG. Congenital diaphragmatic hernia repair in patients on extracorporeal membrane oxygenation: How early can we repair? J Pediatr Surg. 2019 Jan;54(1):50-54. Epub 2018 Oct 5. PMID: 30482539.
  17. Ontaneda A, Annich GM. Novel Surfaces in Extracorporeal Membrane Oxygenation Circuits. Front Med (Lausanne). 2018 Nov 20;5:321. PMID: 30525038.
  18. Cairo SB, Arbuthnot M, Boomer L, Dingeldein MW, Feliz A, Gadepalli S, Newton CR, Puligandla P, Ricca R Jr, Rycus P, Vogel AM, Yu G, Chen Z, Rothstein DH; American Pediatric Surgical Association Critical Care Committee. Comparing Percutaneous to Open Access for Extracorporeal Membrane Oxygenation in Pediatric Respiratory Failure. Pediatr Crit Care Med. 2018 Oct;19(10):981-991. PMID: 30080776.
  19. Moffett BS, Morris J, Galati M, Munoz F, Arikan AA. Population Pharmacokinetics of Vancomycin in Pediatric Extracorporeal Membrane Oxygenation. Pediatr Crit Care Med. 2018 Oct;19(10):973-980. PMID: 30063652.
  20. Moffett BS, Morris J, Galati M, Munoz FM, Arikan AA. Population Pharmacokinetic Analysis of Gentamicin in Pediatric Extracorporeal Membrane Oxygenation. Ther Drug Monit. 2018 Oct;40(5):581-588. PMID: 29957666.
  21. Bembea MM, Cheifetz IM, Fortenberry JD, Bunchman TE, Valentine SL, Bateman ST, Steiner ME; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Recommendations on the Indications for RBC Transfusion for the Critically Ill Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep;19(9S Suppl 1):S157-S162. PMID: 30161071
  22. Labariñas S, Meulmester K, Greene S, Thomas J, Virk M, Erkonen G. Extracorporeal Cardiopulmonary Resuscitation After Diphenhydramine Ingestion. J Med Toxicol. 2018 Sep;14(3):253-256. Epub 2018 Jun 28. PMID: 29956117.
  23. Lohmann P, Hagan JL, Fernandes CJ. Evaluating reflex red blood cell transfusion thresholds in neonatal extracorporeal membrane oxygenation. Transfusion. 2018 May;58(5):1326-1327. PMID: 29683513.
  24. Lasa JJ, Jain P, Raymond TT, Minard CG, Topjian A, Nadkarni V, Gaies M, Bembea M, Checchia PA, Shekerdemian LS, Thiagarajan R. Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Cardiac Population: In Search of a Standard of Care. Pediatr Crit Care Med. 2018 Feb;19(2):125-130. PMID: 29206729.
  25. Yu, YR, Carpenter JL, DeMello AS, Keswani SG, Cass DL, Olutoye OO, Vogel AM, Thomas JA, Burgman C, Fernandes CJ, Lee TC. “Evaluatimg quality of life of extracorporeal membrane oxygenation survivors using the pediatric quality of life inventory survey.” J Pediatr Surg. 2018 May;53:1060-4. PMID: 29551243.
  26. Carpenter JL, Yu YR, Cass DL, Olutoye OO, Thomas JA, Burgman C, Fernandes CJ, Lee TC. “Use of Venovenous ECMO for Neonatal and Pediatric ECMO: a decade of experience at a tertiary children’s hospital.” J Pediatr Surg Int. 2018 Mar;34:263-8. PMID: 29349617.
  27. Thomas JA, Kostousov V, Teruya J. “Bleeding and Thrombotic Complications in the Use of Extracorporeal Membrane Oxygenation.” Semin Thromb Hemost. 2018 Feb;44:20-9. PMID: 28898902.
  28. Lau PE, Cruz S, Garcia-Prats J, Cuevas M, Rhee C, Cass DL, Horne SE, Lee TC, Welty SE, Olutoye OO. 2017. Use of renal near-infrared spectroscopy measurements in congenital diaphragmatic hernia patients on ECMO. Journal of pediatric surgery 52:689-92
  29. Lohmann P, Lee TC, Kearney DL, Fernandes CJ. 2016. Pre-cannulation lung biopsy shortens ECMO course. Pediatric surgery international 32:713-6
  30. Ruth A, McCracken CE, Fortenberry JD, Hebbar KB. 2015. Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system. Critical care 19:397
  31. Nguyen TC, Carcillo JA. 2015. Therapeutic plasma exchange as a strategy to reverse multiple organ dysfunction syndrome in patients receiving extracorporeal life support. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 16:383-5
  32. Desmarais TJ, Yan Y, Keller MS, Vogel AM. 2015. Enteral nutrition in neonatal and pediatric extracorporeal life support: a survey of current practice. Journal of pediatric surgery 50:60-3
  33. Zamora IJ, Shekerdemian L, Fallon SC, Olutoye OO, Cass DL, Rycus PL, Burgman C, Lee TC. 2014. Outcomes comparing dual-lumen to multisite venovenous ECMO in the pediatric population: the Extracorporeal Life Support Registry experience. Journal of pediatric surgery 49:1452-7
  34. Philip J, Burgman C, Bavare A, Akcan-Arikan A, Price JF, Adachi I, Shekerdemian LS. 2014. Nature of the underlying heart disease affects survival in pediatric patients undergoing extracorporeal cardiopulmonary resuscitation. The Journal of thoracic and cardiovascular surgery 148:2367-72
  35. Nguyen T, Musick M, Teruya J. 2014. Anticoagulation monitoring during extracorporeal membrane oxygenation: is anti-factor Xa assay (heparin level) a better test?*. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15:178-9
  36. Hundalani SG, Nguyen KT, Soundar E, Kostousov V, Bomgaars L, Moise A, Hui SK, Teruya, J. 2014. Age-based difference in activation markers of coagulation and fibrinolysis in extracorporeal membrane oxygenation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15:e198-205
  37. Anton-Martin P, Thompson MT, Sheeran PD, Fischer AC, Taylor D, Thomas JA. 2014. Extubation during pediatric extracorporeal membrane oxygenation: a single-center experience. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15:861-9
  38. Musick MA. 2013. Critical appraisal of Zabrocki et al: Extracorporeal membrane oxygenation for pediatric respiratory failure: survival and predictors of mortality. Crit Care Med 2011; 39:364-370. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14:85-8
  39. MacLaren G, Dodge-Khatami A, Dalton HJ, Writing C, MacLaren G, Dodge-Khatai A, Dalton HJ, Adachi I, Almodovar M, Annich G, Bartlett R, Bronicki R, Brown K, Butt W, Cooper D, Demuth M, D’Udekem Y, Fraser C, Guergerian AM, Heard M, Horton S, Ichord R, Jaquiss, R, Laussen P, Lequier L, Lou S, Marino B, McMullan M, Ogino M, Peek G, Pretre R, Rodefeld M, Schmidt A, Schwartz S, Shekerdemian L, Shime N, Sivaragan B, Stiller B, Thiagarajan R. 2013. Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14:S1-2
  40. Guerguerian AM, Ogino MT, Dalton HJ, Shekerdemian LS. 2013. Setup and maintenance of extracorporeal life support programs. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14:S84-93
  41. Fallon SC, Shekerdemian LS, Olutoye OO, Cass DL, Zamora IJ, Lazar DA, Larimer EL, Welty SE, Moise AA, Demny AB, Lee TC. 2013. Initial experience with single-vessel cannulation for venovenous extracorporeal membrane oxygenation in pediatric respiratory failure. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 14:366-73
  42. Fallon SC, Cass DL, Olutoye OO, Zamora IJ, Lazar DA, Larimer EL, Welty SE, Moise AA, Demny AB, Lee TC. 2013. Repair of congenital diaphragmatic hernias on Extracorporeal Membrane Oxygenation (ECMO): does early repair improve patient survival? Journal of pediatric surgery 48:1172-6
  43. Stark RJ, Naik-Mathuria BJ, Lam FW, Olutoye OO, Sutton VR, Shekerdemian LS. 2012. Extracorporeal membrane oxygenation support of a severe metabolic crisis in a child with methylmalonic acidemia. ASAIO journal 58:438-9
  44. Lazar DA, Olutoye OO, Cass DL, Fernandes CJ, Welty SE, Johnson KE, Rycus PT, Lee TC. 2012. Outcomes of neonates requiring extracorporeal membrane oxygenation for irreversible pulmonary dysplasia: the Extracorporeal Life Support Registry experience. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 13:188-90
  45. Lazar DA, Cass DL, Olutoye OO, Welty SE, Fernandes CJ, Rycus, PT, Lee, TC. 2012. The use of ECMO for persistent pulmonary hypertension of the newborn: a decade of experience. The Journal of surgical research 177:263-7
  46. Lazar DA, Cass DL, Olutoye OO, Kim ES, Welty SE, Fernandes CJ, Lee TC. 2012. Venovenous cannulation for extracorporeal membrane oxygenation using a bicaval dual-lumen catheter in neonates. Journal of pediatric surgery 47:430-4
  47. Vogel AM, Lew DF, Kao LS, Lally KP. 2011. Defining risk for infectious complications on extracorporeal life support. Journal of pediatric surgery 46:2260-4
  48. Sivarajan VB, Best D, Brizard CP, Shekerdemian LS, d'Udekem Y, Butt W. 2011. Duration of resuscitation prior to rescue extracorporeal membrane oxygenation impacts outcome in children with heart disease. Intensive care medicine 37:853-60
  49. Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. 2011. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. Journal of pediatric surgery 46:1165-71
  50. Cassady CI, Mehollin-Ray AR, Olutoye OO, Cass DL. 2011. Jugular vein hypoplasia can preclude extracorporeal membrane oxygenation cannulation in the neonate with congenital diaphragmatic hernia: potential identification of the neonate at risk by fetal magnetic resonance imaging. Fetal diagnosis and therapy 30:225-8
  51. Sivarajan VB, Best D, Brizard CP, Shekerdemian LS, D'Udekem Y, Horton SB, Butt W. 2010. Improved outcomes of paediatric extracorporeal support associated with technology change. Interactive cardiovascular and thoracic surgery 11:400-5
  52. Raymond TT, Cunnyngham CB, Thompson MT, Thomas JA, Dalton HJ, Nadkarni VM, American Heart Association Registry of C.P.R. Investigators. 2010. Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 11:362-71
  53. Alexander DC, Butt WW, Best JD, Donath SM, Monagle PT, Shekerdemian LS. 2010. Correlation of thromboelastography with standard tests of anticoagulation in paediatric patients receiving extracorporeal life support. Thrombosis research 125:387-92
  54. Perez A, Butt WW, Millar KJ, Best D, Thiruchelvam T, Cochrane AD, Bennett M, Shekerdemian LS. 2008. Long-distance transport of critically ill children on extracorporeal life support in Australia. Critical care and resuscitation: journal of the Australasian Academy of Critical Care Medicine 10:34
  55. Cavagnaro F, Kattan J, Godoy L, Gonzales A, Vogel A, Rodriguez JI, Faunes M, Fajardo C, Becker P. 2007. Continuous renal replacement therapy in neonates and young infants during extracorporeal membrane oxygenation. The International journal of artificial organs 30:220-6
  56. Macintosh I, Butt WW, Robertson CF, Best D, Shekerdemian LS. 2005. Extending the limits of extracorporeal membrane oxygenation: lung rest for a child with non-specific interstitial pneumonia. Intensive care medicine 31:993-6
  57. Davis PJ, Firmin RK, Manktelow B, Goldman AP, Davis CF, Smith JH, Cassidy JV, Shekerdemian LS. 2004. Long-term outcome following extracorporeal membrane oxygenation for congenital diaphragmatic hernia: the UK experience. The Journal of pediatrics 144:309-15
  58. Brown KL, Walker G, Grant DJ, Tanner K, Ridout DA, Shekerdemian LS, Smith JH, Davis C, Firmin RK, Goldman AP. 2004. Predicting outcome in ex-premature infants supported with extracorporeal membrane oxygenation for acute hypoxic respiratory failure. Archives of disease in childhood. Fetal and neonatal edition 89:F423-7
  59. Cheung MM, Goldman AP, Shekerdemian LS, Brown KL, Cohen GA, Redington AN. 2003. Percutaneous left ventricular "vent" insertion for left heart decompression during extracorporeal membrane oxygenation. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 4:447-9
  60. Brown KL, Shekerdemian LS, Penny DJ. 2002. Transcatheter closure of a patent arterial duct in a patient on veno-arterial extracorporeal membrane oxygenation. Intensive care medicine 28:501-3
  61. Davis PJ, Shekerdemian LS. 2001. Meconium aspiration syndrome and extracorporeal membrane oxygenation. Archives of disease in childhood. Fetal and neonatal edition 84:F1-3

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