Cancer and Hematology Center

Clinical Trials and Novel Therapies

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma (ONITT)

Phase 1 study of irinotecan liposomal with talazoparib or temozolomide in children with recurrent solid tumors or Ewing sarcoma (ONITT).

Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (EPIK-P2)

A Phase 2 study for alpelisib (BYL719) in pediatric and adult patients with PIK3CA-related overgrowth spectrum (EPIK-P2).

Evaluation of the Safety and Efficacy of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis

Evaluation of ELA026 monoclonal antibody for safety and efficacy as a treatment for patients with secondary hemophagocytic lymphohistiocytosis.

Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations (MASter-1)

Phase 2 trial for MAS825 in patients with monogenic IL-18 driven autoinflammatory diseases, including NLRC4-GOF, XIAP deficiency or CDC42 mutations (MASter-1).

Vinblastine/Prednisone versus Single Therapy with Cytarabine for Langerhans Cell Histiocytosis (LCH)

Study for patients newly diagnosed with Langerhan's cell histiocytosis to compare vinblastine/prednisone  versus cytarabine (LCH-REASON).

CD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30)

Phase 1 immunotherapy trial using next generation CD30.CAR T cells  for refractory lymphoma (Hodgkin or non-Hodgkin, including ALCL) (RELY 30).

Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen (MAGENTA)

Phase 1 trial using next generation CD5.CAR T cells for recurrent T-cell leukemia/lymphoma (MAGENTA).

Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)

Gene transfer study available only at our Center for patients with refractory or recurrent B cell Acute Lymphoblastic Leukemia (B-ALL) with expression of CD19, CD20 and/or CD22.

HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children with Ependymoma (PBTC-059)

A multi-center HER2-CAR T-cell immunotherapy trial for children with relapsed or refractory ependymoma (PBTC-059).

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination with Checkpoint Blockade in Patients With Advanced Sarcoma (HEROS 3.0)

Phase 1 immunotherapy trial for children with relapsed or refractory sarcoma using a combination of HER2-CAR T cells with checkpoint blockade (HEROS 3.0).

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders (NACHO COBI)

Frontline study of cobimetinib in patients with recurrent or refractory histiocytic diseases (NACHO COBI).

New immunotherapy for children with solid tumors including liver, kidney and additional rare cancers

Phase 1 immunotherapy trial using 15.GPC3-CAR T cells for children with solid tumors, including liver, kidney and other rare cancers.

Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells (CRIMSON)

Phase 1 cell therapy for children with high-risk T-cell malignancies using CD7-specific CAR expressed on autologous T cells (CRIMSON).

Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

Study to evaluate Eltrombopag for newly diagnosed immune thrombocytopenia (ITP) in children.